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Dr. Sawsan A. Al Madhi

Advocacy Advisor

AlignnEficient Health Consultancies Co LLC, Dubai-London

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Session 3 - Evolving novel patient partnerships in genomic and personalised medicine and digital health - AI and machine learning

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  • Insights on the position paper and the fact that genomic medicine and personalised cancer care must be integrated into national cancer control plans in most regions, using EM Region as an example. We must see this as segregation and integration with other standard approaches in NCCP.

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Session 3 - Evolving novel patient partnerships in genomic and personalised medicine and digital health - AI and machine learning

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  • Insights on the position paper and the fact that genomic medicine and personalised cancer care must be integrated into national cancer control plans in most regions, using EM Region as an example. We must see this as segregation and integration with other standard approaches in NCCP.

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Content

  • Introduction about PCCA and its work
  • What are the 5P’s and the position paper
  • Why the 5P’s are important
  • National Cancer Control Plans & how to start integrating PCC
  • Role of the Patients organizations

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Introduction about PCCA and its work

At the 2021 World Health Assembly, International Alliance Patient Organisation (IAPO) made a statement supporting that patients in lower- and middle-income countries must have access to PHC, Liquid Biopsies, Biomarkers, and general genomic based health technologies. (Statement

WHA74)

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IAPO set up the Personalised Cancer Care Alliance in 2022 with the support from PhRMA MEA as a post COVID-19 initiative to build back better cancer services and to open fast track regulatory and health technology assessment pathways to PHC/LB/BM so that patients can have improved access to innovative cancer medicines and personalised healthcare.

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Introduction about PCCA and its work

PCCA is an alliance of cancer patients, carers, and representatives of patient organizations from the Middle East & North and Sub-Saharan Africa set up to advance health literacy in cancer, advocacy skills and education on personalised cancer care.

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PCCA was set up because we now know that not all patients are the same, and not all cancers are the same, nor are all treatments the same.

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PCCA EMR Position paper

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PCCA EMR Position paper

  • Personalised cancer care (PCC) aims to give the right treatment to the right patient at the right time.

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  • This gives us better outcomes and patient safety, particularly reduced risk of adverse events.

  • We now have health technologies (like, PCC) at our disposal that can help our health systems to become predictive, preventative, participatory, personalised, and pre-emptive (Five P’s)

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What are the 5P’s

We now have innovative health technologies at our disposal that can help our health systems to become:

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1.Predictive

2.Preventative

3.Participatory

4.Personalised

5.Pre-emptive (5ps)

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Leading to a more “Well Functioning” healthcare system if rightly implemented

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Why the 5P’s are important

Predictive

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The health ecosystem, including patient organisations, can very early go on to identify individuals and sections of your population who may develop cancers and other diseases.

This helps segregate at risk populations and prioritise services for them accordingly.

Our National Cancer Control Plans can be fine-tuned to our population’s needs.

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To be predictive you need high quality screening, cancer data collection, and analysis.

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Why the 5P’s are important

Preventative

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In a forewarned is forearmed position, your segregated high- risk patients can then be monitored and treated to prevent onset of disease at a very early stage in their life.

Cancers diagnosed at Stages I and II have far better outcomes than those diagnosed at Stage III and IV.

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An extensive health promotion and health education programmes are needed to be preventative orientated.

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Why the 5P’s are important

Participatory

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Patient co-creation and co-development is important in ensuring our healthcare systems are effective, efficient, and delivering value for money.

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Patient insight, experience and voice MUST be used to incorporate patient preferences into a full spectrum of essential, quality health services, from health promotion to prevention, early detection (screening), treatment, rehabilitation, palliative care and survivorship across the continuum of care.

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Why the 5P’s are important

Personalised

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We can diagnose the right patient and treat them with the right treatment, at the right time, at the right locations, and make the experience as good as possible for them.

This yields the right outcomes desired.

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Personalised cancer care or precision oncology when integrated with digital health strategies has a great potential to address many of the failing in current cancer control and treatment protocols.

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Why the 5P’s are important

Pre-emptive

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Health systems by being pre-emptive address a situation before it becomes worse.

At an individual level, upon discovering that she has BRAC 1 gene, Hollywood actress Angelina Jolie was pre-emptive and underwent a double mastectomy to reduce her chances of getting breast cancer.

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Pre-emptive means building back better now.

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Why the 5P’s are important

These 5Ps within the any Region can improve:

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● Patient health outcomes;

● Patient experience;

● Meet/Matching patient preferences;

● Health system effectiveness, efficiency, safety, acceptability, and accessibility whilst delivering quality healthcare in a compassionate and humanistic way.

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Examples on how health systems can benefit from the 5P’s approach

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PREDICTIVE

Investing in biomarker technologies as they can be used across their full range of healthcare and for the purposes of:

• Predictive-to define the patients who may develop a disease and will most likely benefit from an appropriate matching therapy

• Prognostic- unlike standard diagnostics, this PM approach picks out the aggressive nature of each cancer and then fast track patients and treatments.

Also, very patient centric has you can have an informed conversation (no false hopes) about what the likely outcomes are irrespective what treatment given (k-Ras)

• Early Diagnostic. Opportunistic screening in symptomless patients can pick up a disease which conventional tests

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Examples on how health systems can benefit from the 5P’s approach

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PREVENTATIVE

Introduce breast cancer and colon cancer screening services by applying liquid biopsies and biomarker health technologies and adding these to existing health technologies (Mammography and Colonoscopy)

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Examples on how health systems can benefit from the 5P’s approach

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PARTICIPATORY

All Cancer Registers in the region should have patient participation, patient-engagement, and oversight.

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Patient and carer deep insight should be a part of quality cancer register co-creation, co-production, co-management, and co-reporting:

Nothing about us without us

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Examples on how health systems can benefit from the 5P’s approach

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PERSONALISED

Healthcare system should move away from reactive, paper and analogue based health systems.

To control Cancer in our Region, we must start building back better and look at digital healthcare and artificial intelligence solutions to give us real time and real-world data

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This paradigm shift is vital as it will support health systems to adopt genomic and digital health technologies as ONCO-genes clearly tell us that cancer is a genetic disease in all its aspects.

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Examples on how health systems can benefit from the 5P’s approach

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PRE-EMPTIVE

Investing in National Cancer Control Plans (NCCP) to support country and policy makers in prioritising Cancer Control in their national Health Policy and disease management initiatives within a holistic perspective.

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Role of Patients organizations

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It is PO time to work with the 5P’s and

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Thank You

www.AlignnEficient.com

Dubai | London

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