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Лекція 9

Прадавнє зло

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https://seer.cancer.gov/statfacts/html/common.html

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Date of Download: 10/30/2024

From: Hallmarks of Cancer: New Dimensions

Cancer Discov. 2022;12(1):31-46. doi:10.1158/2159-8290.CD-21-1059

Figure Legend:�In essence: the Hallmarks of Cancer, circa 2022. Left, the Hallmarks of Cancer currently embody eight hallmark capabilities and two enabling characteristics. In addition to the six acquired capabilities—Hallmarks of Cancer—proposed in 2000 (1), the two provisional “emerging hallmarks” introduced in 2011 (2)—cellular energetics (now described more broadly as “reprogramming cellular metabolism”) and “avoiding immune destruction”—have been sufficiently validated to be considered part of the core set. Given the growing appreciation that tumors can become sufficiently vascularized either by switching on angiogenesis or by co-opting normal tissue vessels (128), this hallmark is also more broadly defined as the capability to induce or otherwise access, principally by invasion and metastasis, vasculature that supports tumor growth. The 2011 sequel further incorporated “tumor-promoting inflammation” as a second enabling characteristic, complementing overarching “genome instability and mutation,” which together were fundamentally involved in activating the eight hallmark (functional) capabilities necessary for tumor growth and progression. Right, this review incorporates additional proposed emerging hallmarks and enabling characteristics involving “unlocking phenotypic plasticity,” “nonmutational epigenetic reprogramming,” “polymorphic microbiomes,” and “senescent cells.” The hallmarks of cancer graphic has been adapted from Hanahan and Weinberg (2).�

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https://www.cell.com/fulltext/S0092-8674(11)00127-9

https://linkinghub.elsevier.com/retrieve/pii/S0092867400816839

https://aacrjournals.org/cancerdiscovery/article/12/1/31/675608/Hallmarks-of-Cancer-New-DimensionsHallmarks-of

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Доластатін 10

By PubChem

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Gupta et al, 2013

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Pettit, 1997

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Gunasekera et al, 2022

Caldora penicillata та родичі

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Auristatin Payloads for Antibody–Drug Conjugates (ADCs) Svetlana O. Doronina* and Peter D. Senter

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10915760

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Блеоміцин

By Wikipedia

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DOI:10.1074/jbc.273.44.28837

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https://doi.org/10.1016/j.cclet.2018.05.004

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https://doi.org/10.3390/cancers12051288

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Theonella swinhoei

https://www.sealifebase.ca/summary/Theonella-swinhoei.html

https://www.reeflex.net/tiere/6265_Theonella_swinhoei.htm

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Протеузіни (та політеонамід, як їх представник)

http://dx.doi.org/10.1016/j.cbpa.2015.11.002

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https://pmc.ncbi.nlm.nih.gov/articles/PMC7281193/

https://www.pnas.org/doi/full/10.1073/pnas.1616234114

https://www.nature.com/articles/nature12959

https://pubs.rsc.org/en/content/articlelanding/2021/sc/d0sc06835g

Додаткова література

https://www.sciencedirect.com/science/article/abs/pii/S0006291X23013086

https://pubs.acs.org/doi/abs/10.1021/acs.chemrev.6b00623

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