Pathway to Recovery

IN AUTISM SPECTRUM DISORDERS

Dr. Necip Cem KINACI, MD

President of Autism Medical Institute

Member of Executive Committee of The Council of Administration of the World Autism Organisation

AUTISM

Signs & Symptoms

Causes

Introduction/Background:

• Autism is the most common disease of the Pervasive

Developmental Disorders.

• There are many theories as to the cause of Autism Spectrum

Disorders (ASD) such as

• abnormal cerebral blood flow to areas of the brain,
• birth trauma or lack of oxygen before, during or after delivery.
• brain injury,
• infections,
• reactions to vaccines,

Predisposing Factors for ASD

🙐 New Genetics

🙐 Human genome can be affected by nutrition.

🙐 There is an interplay between genes and

environment.

🙐 Genes can be turned on and off.

🙐 Single Nucleotide Polymorphisms (SNP) are a slight variation in the genetic code resulting in abnormal protein or enzyme production.

🙐 SNP’s are common in the population.

🙐 98% of children with ASD have a SNP in their MTHFR gene (J Am Phys Surg 2004;9:106-108.)

Predisposing Factors for ASD

🙐 Heavy Metal Burden

​

Mom

• amalgams
• fish consumption
• rhogam
• vaccines
• environment
• occupation
• oral contraceptives

Patient

• Immunizations
• environmental toxics
• antibiotics
• immune issues
• gastrointestinal

permeability

Predisposing Factors for ASD

🙐 Infectious Agents

Virus

🙓 Measles

🙓 HHV6

🙓 CMV

Bacteria

🙓 Streptococcus

🙓 Clostridia

🙓 Borrelia

Fungal

🙓 Candida

🙓 (LIA Conference 2008

Fort Lee, NJ )

• Biochemical aftermath in ASD are
• Impaired detoxification,
• depletion of antioxidants,
• oxidative stress,
• mineral deficiency,
• mitochondrial dysfunction,
• gastrointestinal dysfunction,
• chronic BBB dysfunction
• and immune system dysregulation

​

• Many cases of ASD today are secondary to cases of

gut-brain inflamation.

Biochemical Aftermath in ASD

🙐 Gastrointestinal Dysfunction

🙒 Dysbiosis (Yeast, Bad Bacteria, Virus…)

🙒 Malabsorption

🙒 Maldigestion (Enzyme deficiency, IgG food

sensitivities, urinary peptides)

🙒 Autistic Enterocolitis / Lymphonodular

Hyperplasia

​

• Am J Clin Nutr. 2004 Dec;80(6):1611-7

Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.

James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA.

Biochemical Aftermath in ASD

🙐 Immune System Dysregulation

🙒 Proinflammatory Cytokines

🙒 Microglial Activation

🙒 Th1/ Th2 skewing

🙒 Decreased Natural Killer Cell

🙒 Increased Autoimmune Markers

• James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec;80(6):1611-7

Biochemical Aftermath in ASD

🙐 Impaired Detoxification

🙒 Undermethylation, Remethylation Defects

🙒 Sulfation Defects (phenolsulfertransferase, sulfite oxidase)

🙒 Cysteine Deficiency

🙒 Glutathione Deficiency (GSH)

​

• James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec;80(6):1611-7

Biochemical Aftermath in ASD

🙐 Heavy Metal Overload - Oxidative Stress

🙒 Thimerosal (Mercury), Arsenic, Lead

🙒 Depletion of Antioxidants, Glutathione and Metallothionein

🙒 Mineral Deficiency ( Zinc, Magnesium )

🙒 Mitochondrial Dysfunction

​

• James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec;80(6):1611-7

🙐 “Leaky gut” is common in autism and implies that the intestines are more permeable than normal.

Healthy Gut Leaky Gut & Malabsorption

​

🙐 This can play a major role in food allergies and in soy, gluten and casein sensitivity.

Soy, gluten and casein can enter the circulation

through this “leaky gut” and travel to the brain.

Causes of “Leaky Gut” ?

🙐 Overuse of antibiotics, steroids

🙐 Poor diet high in refined foods and sugars

🙐 Nutritional deficiencies

🙐 Incomplete digestion

🙐 Heightened exposure to environmental toxins

🙐 Stress

Stool pattern is a very good hard copy report of our metabolism

🙐 There is also an imbalance in intestinal flora.

🙐 This can lead to fungal infection in some children.

🙐 Candida is the most common.

Biochemical effects of toxic overload

🙐 Destroy cell membranes

🙐 Increase free radical activity

🙐 Deplete sulfur emzymes

🙐 Displace emzyme cofactors

🙐 Oxydize enzymes

🙐 Attack organs

🙐 Effect gastrointestinal flora and integrity

🙐 Immunotoxic

🙐 Denature proteins

🙐 Carsinogenic

🙐 Mineral deficiency

🙐 Neurons Before Mercury Exposure >

🙐 Neurons During Mercury Exposure >

🙐 Neurons After Mercury Exposure >

🙐 Mercury and possibly other toxic metals present at

high levels in autistic children.

🙐 Every child with autism should do a

DMSA challenge test.

​

🙐 For chelation treatment, I recommend oral DMSA,

under guidance of experienced physician,

with regular urine testing and kidney/liver function testing (every 2-3 months).

🙐 Children under 6 will benefit most,

🙐 children under 12 may benefit,

🙐 older children/adults have smaller chance of

modest benefit.

PERFUSION CHANGES SECONDARY TO HEAVY METAL INTOXICATION DETECTED BY BRAIN PERFUSION SPECT IN CHILDREN WITH AUTISM

Cem Kinaci, Serpilgul Kinaci

Dept. of Nuclear Medicine, German Hospital, Istanbul – Turkey

Results: (683 patients)

All of them have elevated or very elevated lead and 21.38% of them have elevated or very elevated mercury and some other toxic heavy metals such as nickel (14.05%), aluminum (6.00%), tin (3.51%), thallium (3.51%),

arsenic (2.78%), tungsten (2.64%), uranium (2.49%) on their DMSA provocated urine toxic metal analyses.

All of the patients had abnormal SPECT scans revealing

focal areas of decreased perfusion.

Decreased perfusion of temporal (45.66%), frontal (29.91%), primary motor cortex (8.20%), primary somatosensorial cortex (3.88%),

basal ganglia (4.08%), parietal (5.02%), occipital (2.01%)

and cerebellar (1.21%) areas were noted on brain SPECT.

By contrast all patients had normal MRI findings.

it is clear that, heavy metal detoxification

was greatly facilitated

by the elimination of EMR

from the treatment environment.

🙐 In most cases, autistic children have mineral deficiency due to poor uptake of nutrients and other unexplainable reasons.

​

Autistic children often show deficiency in

🙐 selenium

🙐 zinc

🙐 magnesium

🙐 molybdenum

🙐 mangan

🙐 chromium

🙐 vanadium

🙐 Copper

🙐 It is important that the supplement doesn’t contain

copper since it is the only mineral that autistic

children usually have to much of.

🙐 Excess can cause erratic behavior, hyperactivity,

poor focus, yeast issues.

🙐 Reduces zink and molibdenum

🙐 By administering copper we would make things

worse.

​

🙐 Selenium

🙐 Has an important role on glutathione metabolism

and thyroid metabolism.

🙐 Most of the autistic children

have low selenium levels in blood.

🙐 It should also be handled cautiously.

🙐 Molibdenum

🙐 Deficiency leads to yeast and sulfation issues

🙐 Reduces tungsten and copper

​

🙐 Zink

🙐 Deficiency can cause immune, language, attention/focus issues.

🙐 Magnesium

🙐 Deficiency can cause hyperactivity, anxiety, muscle

spasms, enuresis.

🙐 Reduces aluminum

🙐 Antagonizes calcium

​

🙐 Calcium

🙐 Excess leads to hyperexitability

🙐 Deficiency leads to poor bone mineralization, rigidity in muscles

🙐 Reduces lead and aluminum

🙐 Vitamin C

🙐 Vitamin C has an important role on neurotransmitter metabolism.

🙐 Vitamin C can detox mercury, lead, arsenic and some other toxins from the body.

Dolske MC, Spollen J, McKay S, et al. A preliminary trial of ascorbic acid as supplemental therapy for autism. Prog Neuropsycholpharmacol Biol Psychiatry 1993;17:765–74.

Rimland B. Vitamin C in the Prevention and Treatment of Autism

Autism Research Review International. 1998 ;12 (2):3

🙐 Methylcobalamin

🙐 is the only compound of the B12 familly which is the most important activator for methionine- homocysteine path.

🙐 This path activates the most important detox system in the body.

​

🙐 Vitamin B6

🙐 is found in cystein production, which is needed for glutathione.

Lelord G, Muh JP, Barthelemy C, et al. Effects of pyridoxine and magnesium on autistic symptoms: Initial observations. J Autism Developmental Disorders 1981;11:219–29.

Martineau J, Garreau B, Barthelemy C, et al. Effects of vitamin B6 on averaged evoked potentials in

infantile autism. Biol Psychiatr 1981;16:627–39.

Rimland B, Callaway E, Dreyfus P. The effect of high doses of vitamin B6 on autistic children: a

double-blind crossover study. Am J Psychiatr 1978;135:472–5.

Rimland B. Vitamin B6 versus Fenfluramine: a case-study in medical bias. J Nutr Med 1991;2:321–2.

🙐 Vitamin E

🙐 is also a good antioxidant

🙐 but is not highly recommended, because most Vitamin E

is soy based.

🙐 Autistic children have a tendency to be intolerant to

soy products.

🙐 Vitamin E which is not Soy based can be used.

🙐 Vitamin K

🙐 an anti-oxidant that is more powerful than Vitamin E or CoQ10.

🙐 Vitamin K, is able to potently inhibit

glutathione depletion-mediated oxidative cell death.

🙐 Vitamin K is involved in the development

of the nervus system.

🙐 Vitamin D

🙐 Many patients with chronic inflammatory diseases like ASD are

deficient in 25-hydroxyvitamin-D

🙐 Vitamin D has a role to decrease oxidative stress in brain.

​

🙐 Vitamin D Receptor gene

🙐 92.5% of ASD patients in our study group have genetic mutations of VDR Taq and/or VDR Fok

🙐 VDR affects transcription of at least 913 genes and impacts processes ranging from calcium metabolism to expression of key antimicrobial peptides.

🙐 Many of these genes have long been associated with autoimmune diseases and cancers.

🙐 Oxidative stress

is a state of imbalance in which oxidants overwhelm

the antioxidant defense, causing excess physical damage and

impaired function in

biomolecules.

🙐 Genetic weakness in antioxidant protection:

Metallothionein, Glutathione, APO-E2, etc.

​

🙐 Incompetent intestinal and blood/brain barriers.

​

🙐 Toxic amounts of mercury, lead, copper etc. invade the brain, damaging brain cells and disabling MT proteins needed to complete maturation of the brain.

Consequences of Oxidative Stress Mirror Classic Symptoms of Autism

🙐 Hypersensitivity to mercury and other toxic metals.

🙐 Hypersensitivity to certain proteins (casein, gluten, etc)

🙐 Poor immune function

🙐 Disruption of the methylation cycle

🙐 Inflammation of the brain & G.I. tract.

🙐 Depletion of glutathione & metallothionein

🙐 Excessive amounts of “unbound” copper

Free Radicals

🙐 Defined as an atom that has lost an electron and as a

result, has a net (+) charge.

🙐 Free radicals are explosive,

🙐 chemically reactive species that if not controlled, cause damage to cell membranes by lipid peroxidation.

Sources of free radicals

🙐 Radiation

🙐 Sunlight

🙐 Pollution

🙐 Cooked or rancid fats

🙐 Chemicals

🙐 Heavy metals

🙐 Insecticides

🙐 Herbicides

🙐 Halothane

🙐 Chlorine

🙐 MSG

🙐 Aspartame

🙐 Food color

🙐 Cu and Fe

🙐 Allergies

🙐 Stress

🙐 Infections (such as candida)

Free radicals are increased by

🙐 Excessive Iron and Copper

🙐 Other inflamatory problems such as allergies.

Vitamin C Vitamin E Vitamin A B vitamins Selenium Magnesium

Zinc Carnosine Carnitine CoQ10 DHA

Vanilla

Free radicals are controlled by antioxidant nutrients

Autism and Neuroinflammation

A – Normal control cerebellum

B – Autistic brain with loss of Purkinje cell layer (P) and granular cell layer (G)

Vargas et al., 2005

​

​

​

G

Most people are familiar with

MRI (magnetic resonance imaging) and CAT (computerized axial tomography) scans, which are superb at depicting structural anatomy.

However, neither is designed for or is capable of measuring the brain activity.

🙐 A specialized tool, the SPECT scan,

(Single Photon Emission Computed Tomography) has been proven effective in this task

and it is the primary tool to objectively measure

the effectiveness of HBOT on patients.

🙐 Specifically, SPECT scanning show actual brain functioning, in visual terms.

​

🙐 It can help doctors to see

🙒 how blood is flowing through different areas within a

patient's brain,

🙒 visualize brain metabolism,

🙒 and make a better diagnosis of his/her condition.

During SPECT scanning, a radioactive "tracer" agent is

injected into a vein in the hand or arm.

The tracer localizes in an area of the brain where it can then be "photographed"

Only viable tissue can absorb the tracer, which breaks

down harmlessly within a few hours.

A special gamma camera aimed at the head pinpoints

the position and energy of photons emitted, as the

tracer disintegrates.

🙐 As inert (dead) cells do not absorb the

tracer at all,

​

🙐 SPECT scanning can distinguish between living and dead (necrotic) tissue.

​

🙐 SPECT scanning can also identify between recoverable brain cells (referred to as sleeping cells, idling neurons, or the ischemic penumbra).

Case :

8 YO boy with autism has decreased function at right temporal and right frontal areas.

WE NEED THE AUDITORY AREA IN THE BRAIN

AS WE NEED EARS AND NERVES

SCANNING

RECOVERY

PROCESSING

DISCUSSION

UNIVERSAL CAMLICA HOSPITAL Nuclear Medicine Department - ISTANBUL

🙐 With this method we can see that most autistic children have decreased activity at the temporal and frontal lobes of the brain which has to do with

speech and understanding.

​

🙐 The important question is if the area with low activity has the possibility to recover.

​

🙐 If the living brain tissue is determined to be

recoverable or in an electrically inactive or idling state,

​

🙐 HBOT may substantially

and/or permanently revive them.

🙐 When treating autistic children,

it is not enough to cleanse the brain from toxic heavy metals by using chelation.

​

🙐 Simultaneously the digestive system needs to be treated in order for optimal results.

​

🙐 Areas that have decreased function due to accumulated heavy metals need to be activated.

www.oceanhbo.com www.harchhyperbarics.com

🙐 With “Hyperbaric Oxygen Therapy” it is possible to

treat both brain and digestive system.

🙐 This has been used since 1972 by Dr. Richard Neubauer/USA, with excellent results.

Hyperbaric Oxygen Therapy is a medical treatment that uses the administration of 100 % oxygen at controlled pressure (greater than sea level) for a

prescribed amount of time usually 60 to 90 minutes.

🙐 HBOT is NOT to be confused with “hyperoxygenation”, which is breathing in oxygen in regular pressure

(1 atmosphere)

🙐 Inhaling large amounts of oxygen in regular pressure can be damaging to the brain.

🙐 Under no circumstances should the child breathe high dose of oxygen from an oxygen tube.

🙐 Pressure levels, Length of sessions, Numbers of sessions are individually adjusted after the childs needs.

🙐 Protocols that are beneficiary for other diagnoses

are not relevant for autistic children.

🙐 Only specialists may treat with “Hyperbaric Oxygen Therapy”.

🙐 The treatment is done in submarine boat like chambers (hyperbaric chambers) that are on land.

​

🙐 By using pressure, SCUBA diving is simulated.

🙐 With the help of special masks and hoods

🙐 it is possible to breathe 100% oxygen.

🙐 During modern HBOT, the patient breathes pure, 100% oxygen under increased atmospheric pressure.

​

🙐 The air we normally breathe contains only 19-21% of this essential element;

​

🙐 Via HBOT, the concentration of pure oxygen dissolved into the bloodstream is dramatically increased (up to 2,000 %) with virtually no energy expenditure.

Without changing the temperature,

when you increase the pressure, you can get more gas in solution

🙐 In addition to the blood, all body fluids

(including the vital lymph and cerebrospinal fluids) are infused with the healing benefits of this molecular oxygen.

>

>>

>>>

>>>>

Oxidative Stress and HBOT

• Oxidative stress is caused by an imbalance of oxidants and

antioxidants

• At pressures below 2.0 atm, HBOT can decrease oxidative

stress by increasing anti-oxidant enzyme levels such as:

• Superoxide dismutase (SOD)
• Catalase
• Glutathione peroxidase
• Heme-oxygenase 1
• Paraoxonase

​

• At pressures above 2.5 atm, the literature is conflicted and HBOT may actually increase oxidative stress...

RESEARCHERS FIND TEXTBOOK-ALTERING LINK BETWEEN BRAIN & IMMUNE SYSTEM

​

🙐 In a stunning discovery that overturns decades of textbook teaching, researchers at the University of Virginia School of Medicine have determined that the brain is directly connected to the immune system by vessels previously thought not to exist.

🙐 That such vessels could have escaped detection when the lymphatic system has been so thoroughly mapped throughout the body is surprising on its own, but the true significance of the discovery lies in the effects it could have on the study and treatment of neurological diseases ranging from Autism to Alzheimer’s disease to Multiple Sclerosis.

Brain is like every other tissue

connected to the peripheral immune system through

https://news.virginia.edu/content/researchers-find-textbook-altering-link- between-brain-immune-system#sthash.S3i9toIu.dpufatic

Meningeal Lymph vessels

🙐 Hyperbaric oxygen treatment which now being used for autistic children is to address the neuroinflammatory component of the disorder.

Professor of Hyperbaric Medicine, P B James MB ChB DIH PhD FFOM Oxygen and the inflammatory cell.

Nature 2003 vol 422 675-676. Carl Nathan

🙐 There is emerging evidence of chronic blood-brain

barrier dysfunction in these children.

​

🙐 The use of high dosage oxygen is based on the latest

research into its role in the control of inflammation.

• A scientific study completed at the University of Pennsylvania School of Medicine reports that HBOT is a safe and effective way to mobilize stem cells.
• Stem cells, also called progenitor cells, are crucial to

the repair of injured tissues and organs.

• HBOT increase by eight-fold the number of

circulating stem cells throughout the body.

• Healthy recovery of injured and diseased tissues is

the ultimate goal and stem cells play an essential role.

HYPERBARIC OXYGEN THERAPY INCREASES STEM CELLS BY EIGHT-FOLD

BENEFICIAL EFFECTS OF HBOT

• Angioneogenesis from the addition of O2.
• Angioneogenesis from the removal of O2.
• Increases in blood flow independent of new blood vessel formation.
• Decreasing levels of inflammatory biochemicals.
• Up-regulation of key antioxidant enzymes and decreasing oxidative stress.
• Increased oxygenation to functioning mitochondria.
• Increased production of new mitochondria
• Bypassing functionally impaired hemoglobin molecules secondary to abnormal porphyrin production.
• Improvement of the immune system and the autoimmune system.

BENEFICIAL EFFECTS OF HBOT

• Decreasing the bacterial and yeast load systemically

and in the gastrointestinal system.

• Decreasing the viral load found systemically and the viral load in the gastrointestinal mucosa.
• Increases in the production of stem cells in the bone marrow with transfer to the central nervous system.
• Increases direct production of stem cells by certain areas in the brain.
• Increased production and utilization of serotonin.
• The possibility that oxidation may help rid the body

of petrochemicals (theoretical only).

• The possibility that oxidation may help rid the body

of mercury and other heavy metals (theoretical only).

AUTISM

Cerebral Hypoperfusion

Oxidative

Stress

​

Neurodegenerative Disease

Neuroinflammation

and GI inflammation

Excretion of Porphyrins

Hypoperfusion

Cerebral

Oxidative Stress

Neurodegenerative Disease

Neuroinflammation and GI inflammation

HBOT

Stem Cells

Excretion

of Porphyrins

🙐 Through these sessions we make sure that the brains inactive cells (idling neurons) develop to normal function.

🙐 When the brain cells are able to utilize the molecules of oxygen in the air,

the treatment is finished.

🙐 To confirm this, a new SPECT is done.

(Dr.Neubauer & Dr.Harch’s Scan-Dive-Scan Protocol)

Effects of HBOT

Calvert et al., 2002

Hypoxia Ischemia

Hypoxia Ischemia + HBOT

Control Rat Brain

Brain SPECT scan before HBOT (A.S. 7 YO Boy)

Brain SPECT scan after 90 sessions of HBOT

N.L.’S HANDWRITING BEFORE HBOT

N.L.’S HANDWRITING AFTER HBOT

HYPERBARIC OXYGENATION IN RESTORATION OF THE COGNITIVE FUNCTIONS IN CHILDREN

Jovanovic Simic N.³, Terzic I .³, Jovanovic T.¹, Brkic P.², Mitrovic A.¹

¹Centre for hyperbaric medicine, Belgrade, Serbia,

² Institute of Medical Physiology,School of Medicine, University of Belgrade ³Institution Faculty of Special Education and Rehabilitation, University of Belgrade, Belgrade, Serbia – 2012 EUBS

Some examples from N.V, 5 year old boy

Before HBO

• HBO and Stimulative treatment for psychomotor development

After 10 HBO session and stimulative program for psychomotor reeducation

Before HBO

After 20HBO session and stimulative program for psychomotor reeducation

After 13 HBO session and stimulative program for psychomotor reeducation

Before HBO

Before HBO

Drawing before HBO

After 36 HBO session and stimulative program for psychomotor reeducation

Draw and color after 80 HBO session and stimulative program for psychomotor reeducation

European Underwater and Baromedical Society

on Diving & Hyperbaric Medicine

33rd Annual Scientific Meeting of the

September 8th - 15th, 2007 Sharm el-Sheikh, Sinai, Egypt

​

🙐 BRAIN PERFUSION CHANGES AFTER HYPERBARIC OXYGEN

THERAPHY IN THE CHILDREN WITH AUTISM.

KINACI Cem¹, ALAN Mustafa², HATIPOGLU Kadir³

¹DAN! Practitioner and Nuclear Medicine Physician, IMC Hospital, Mersin, Turkey.

²Aerospace Medicine Physician, Baromed Hyperbaric Center, Ankara, Turkey.

³Diving Medicine and Pulmonary Disease Physician, Gulhane Military Medical Academy, TSK

Rehabilitation Center, Ankara, Turkey.

​

🙐 Materials/Methods: This study shows the brain perfusion changes secondary to brain inflamation and effects of HBOT in 108 children with autism.

​

🙐 Conclusions: After HBOT, extensive perfusion improvements involving the brain were found in this study. SPECT scans may be more sensitive in reflecting the pathophysiology of autism than MRI.

www.cemkinaci.com

Prof. dr Tomislav Jovanović, fiziolog, odavno dokazuje da kiseonik utiče i na razvoj mališana. Tom temom se posebno bavi dr Cem Kinaci iz Turske koji tvrdi da kod dece sa autizmom postoje neuroinflamacije: „Ako postoji inflamacija, to je zapaljenska bolest, dakle terapija kiseonikom će pomoći. Ta metoda je veoma sigurna ne samo za decu sa autizmom već i za onu koja

imaju neki neurološki problem, zastoj.ˮ

Prof. dr. Tomislav Jovanovic, a physiologist, has long proven that oxygen also affects the development of toddlers. Dr Cem Kinaci from Turkey is particularly concerned with this, claiming that there is neuroinflammation in children with autism: “If there is inflammation, it is an inflammatory disease, so oxygen therapy will help. This method is very safe not only for children with autism, but also for those who have some neurological problem, stagnation.ˮ

2017

NUTRIGENOMICS

🙐 Nutrients can turn on gene activity favorable to health, and turn off unfavorable activity.

🙐 The companion science of Nutrigenomics helps us to determine the specific nutrients needed to prompt healthy gene expression in certain key genes, so that people can thrive.

🙐 By knowing what gene changes are present in each child, we can target nutritional support to his or her specific combination of genes.

Autism: Pathways to Recovery 2009, Amy Yasko

Autism: Pathways to Recovery 2009, Amy Yasko

NUTRIGENOMICS

🙐 Using specific nutritional support, we optimize that

child’s gene expression to improve the body’s ability

to derive nutrients from food,

to produce a balanced immune response, to detoxify,

to balance mood and calm neurological activity

Autism: Pathways to Recovery 2009, Amy Yasko

NUTRIGENOMIC DNA TESTING

CHILD MOTHER FATHER

RNA – BASED NUTRITION

🙐 The field of nutrigenomics is the study of how different foods can interact with particular genes to decrease the risk of diseases.

🙐 Biomolecular nutrigenomics takes this concept a step furter, analyzing the molecular signaling pathways that are affected by spesific single-site base changes, and than utilizes combinations of nutrients, foods and natural RNA’s to by-pass mutations and restore proper pathway function.

🙐 Genetic By-pass provides that understanding.

🙐GcMAF

(glycoprotein macrophage activating factor)

​

🙐Nagalase

(alpha-N-acetylgalactosaminidase).

How does GcMAF work ?

🙐 In a healthy person your GcMAF acts as a "director" of your immune system, and also instructs macrophages in your bloodstream to kill malignancies.

​

🙐 But viruses and malignant cells like cancer send out an enzyme called Nagalase that neutralises your GcMAF; so the macrophages never get the message to go into action – in this way diseases become chronic by suppressing the immune system, and cancer cells grow unchecked.

{

Phagositoz !

GcMAF can reverse diseases that attack the immune system

🙐 Chronic inflamation,

🙐 Bacterial and viral infections,

🙐 Autism,

🙐 Chronic Herpes,

🙐 Chronic Acne,

🙐 CFS,

🙐 XMRV,

🙐 Lyme disease,

🙐

🙐

🙐

🙐

🙐

🙐

🙐

🙐

AIDS, HIV,

Fibromyalgia (all of which we've had success with ourselves),

Osteoporosis, Hodgkin’s, Lupus,

MS,

Parkinson’s,

and various types of Immune dysfunction.

History

🙐 Especially in the last 50-100 years increased consumption of unnatural food products and food additives, solid fats like margarines and pressed oil

like sunflower and corn oil led to a decrease in fresh fruit

& vegetable and food prepared in saucepan

consumption.

🙐 Our gene structure and subsequent chemical reactions does not have the complete ability to deal with these unnatural foods.

🙐 The discordance between genes and foods leads to extreme increase in chronic diseases like obesity, diabetes, hypertension, stroke, ulcer, asthma, rheumatoid diseases, chronic tiredness, cancer and osteoporosis.

• gluten (from grains)
• casein (from dairy)

- soy

Major Food Components Shown to Play a Part in Autism

The GFCFSF diet for autism

(gluten-free, casein-free, soy-free diet)

was proposed to correct the imbalance

in opioids that was seen in about 80% of these children.

Grandma

knew best

🙐 Autistics do not have the stomach enzymes that normally break down the proteins from milk and wheat (and other grains).

🙐 This allows undigested foods to travel through the stomach and into the intestines, where they are absorbed through a “leaky gut“.

🙐 In normal cases, protein breaks down to amino acids in the digestive system.

🙐 But in autistic children gluten, casein and soy protein breaks

down to peptides called

“casomorphin”, “gliadorphin”.

Dohan FC, Grasberger JC. Relapsed schizophrenics earlier discharge from the hospital after cereal-free, milk free diet. Am J Psychiatry 1973; 130(6): 685-88.

Reichelt K-L, Ekrem J, Scott H. Gluten, milk proteins and autism: dietary intervention

effects on behavior and peptide section. J Appl Nutr 1990;42:1–11.

🙐 By implementing the GFCFSF diet, these proteins will not

be absorbed and are unable to cause harm.

🙐 It has been noted in many cases that constipation,

diarrhoea, self-injurious behaviour and “dazed” sensations have all improved simply by removing soy, gluten and casein from the diet.

🙐 Treatments are more beneficial when using both Chelation

and HBOT.

🙐 By implementing a gluten, soy and dairy free diet to this treatments, many autistic children have positive effects.

Reichelt KI, Hole K, Hamberger A, Saclid G, Edminson PD, Braestrup CB et al. Biologically active peptide-peptide containing fractions in schizophrenia and childhood autism. Adv Biochem Psychopharmacol 1981; 28:627-43.

🙐 Cow and sheep milk contains casein A1 95% and this can breaks down to peptides called “casomorphine”,

🙐 But goat milk contains casein A2 95%. (horse, donkey and camel milk is same with goat milk)

🙐 Human milk contains casein A2 98% and casein A1 2%

🙐 I recommend goat milk to autistic children.

🙐 It is not as healthy as it is claimed to be.

🙐 It decreases both the protein digestion and absorption of calcium, iron and zinc (phytates).

🙐 Impairs thyroid hormone synthesis.

🙐 Can lead to precocious puberty, menstrual irregularities and sterility.

🙐 Vitamin D deficiency

🙐 Osteoporosis

🙐 Indigestion

🙐 Immune deficiency

🙐 Dementia

🙐 Cancer

🙐 Myocardial disease

Soy

Diet Trial for 3-6 months

🙐 Casein-free

🙐 Gluten-free

🙐 Soy-free

🙐 Sugar-free

Clean up the Diet

🙐 Avoid sugar and refined starch

🙐 Add

🙒 high protein

🙒 high fiber diet

🙒 high good fats

🙒 blue foods

🙒 garlic

🙒 fermented foods

🙒 turmeric

🙐 maximize antioxidants

🙐 increase cruciferous veggies

Avoid Sugar

🙐 Refined sugar (fructose included) and food containing refined sugar (jam, marmalade, cake, biscuit, pastry, wafer etc) are forbidden.

🙐 Corn syrup, brown-sugar fructose and other

sweeteners are not better alternatives.

​

Honey is natural

🙐 Natural honey gives health.

🙐 Can be consumed up to 1-2 teaspoon a day.

🙐 Unnatural honey which contains refined sugar is

strictly forbidden.

Remove Junk Food & Preservatives

🙐 Limit processed and preserved foods,

🙐 Organic is best

what you see may not always be what you expect !

Avoid Excitotoxins

🙒 Caffeine,

🙒 MSG,

🙒 NutraSweet,

🙒 red/yellow food dyes,

🙒 nitrites,

🙒 sulfites,

🙒 glutamates,

🙒 preservatives

Fried Food

It harms the human cells.

If must be consumed, must be prepared with butter or hazelnut oil.

In order to lessen the harmful effects of fried foods, eat

yoghurt with garlic and green vegetables with them.

MOST OF THE FAST FOOD CONTAINS PRESERVATIVES

Drink Plenty of Filtered Water

🙐 Drink 6-8 glass of water a day.

🙐 You can drink water half an hour before or after your meals.

🙐 You must drink 1-2 glasses of water before going to sleep.

Limit Intake of Phenolics

🙐 Red apples,

🙐 Red grapes,

🙐 Strawberry

Limit Sources of Copper

🙒 chocolate,

🙒 shellfish,

🙒 tap water,

🙒 artificial food dyes

Cooking Styles

🙐 Foods must be cooked slowly with their own water.

🙐 Besides traditional cooking like stewing, turbo ovens can be used. This will prevent the loss of the nutritional ingredients.

🙐 Fast cooking styles (like microwave), lead to loss of the nutritional ingredients and could also lead to cancer. Never microwave in plastics or Styrofoam

🙐 Try not to consume frozen food products.

🙐 Try not to consume conserved food also. ( Unless they are homemade ! ).

Eliminate Sea Food

🙐 Eliminate seafood

🙐 Give fishoil

🙐 Fish oil

🙐 Source of life!

🙐 Contains much omega-3 fatty acids.

🙐 From infancy to adulthood, every human being must consume fish

oil.

🙐 At least 300-500 mg/day active metabolites (EPA+DEHA) must be

taken. In chronic illnesses the dose can be up to 2000-4000

mg/day (Under doctor control)

🙐 Fat oil does not make you fat!

🙐 Can be used both in winter and summer.

🙐

But cod liver oil must not be used with caution in summer months

because of its high vitamin D content.

Frequency of the Meals

🙐 At the start of the diet you must eat frequently because

of the risk of hypoglycemia.

🙐 Your insulin will be trained in 1-2 weeks and eating 3 times

a day (4-5 times for children) will be enough.

🙐 Begin meals with raw fruits and veggies

🙐 Chew every morsel !!!

Add Good Fats

🙐 olive

🙒 The perfect oil!

🙒 Rich in monounsaturated fatty acids

🙒 True olive oil congeals by freezing.

🙒 Virgin type olive oil must be preferred.

🙒 Riviera type is the second choice (hot pressed).

🙐 coconut

🙐 flax

Avoid Hydrogenated and Trans Fats

🙐 Seed oils

🙐 Sunflower oil, cotton oil, corn oil, soy oil consist polyunsaturated oils rich in omega-6.

🙐 They disturb the Omega-6/omega-3 balance by increasing omega-6.

🙐 They also have a degenerative (hot pressed, degenerative trans-fatty acids! free radicals) effect on human organism.

🙐 Do not use them !

Buy Organic Meat and Eggs

🙒 hormone-free,

🙒 antibiotic-free,

​

🙐 Red Meat

🙐 Must not be overcooked.

🙐 Must not be fat free.

​

🙐 Egg

🙐 The highest quality protein

source.

🙐 1-4 eggs per day can be eaten.

We can be as conscious as ants !

Low Oxalate Diet for Autism

🙐 What is oxalate?

🙐 Oxalate = 2 carbons + 4 oxygen atoms

🙐 Plants use oxalate:

🙒To sequester and store excess

calcium.

🙒To make crystals that catch light for photosynthesis.

🙒To form sharp edged crystals to defend themselves from predators.

Susan Costen Owens, MAIS - LWO@iadfw.net

Oxalate’s structure makes it a chelator of minerals.

🙐 Calcium

🙐 Zinc

🙐 Cobalt

🙐 Iron

🙐 Magnesium

🙐 Manganese

It also binds minerals that are toxic:

🙐 Aluminum

The strongest bonds are to

🙐 Mercury

🙐 Lead

🙐 If the levels of oxalate in tissues becomes excessive,

then those tissues may retain toxic metals.

🙐 Excess oxalates may also bind and change the nutritional

availability or the function of necessary minerals.

🙐 Oxalate in small amounts is normal to our cells.

🙐 The only positive role known for oxalate is its regulation of the level of calcium that is stored in the endoplasmic reticulum.

🙐 This storehouse of calcium can be used in cell

signaling or in managing the life cycle of the cell.

What Happens When Oxalate Levels Excess ?

🙐 When oxalate levels within cells becomes excessive, then this can lead to two processes of cell death:

🙐 APOPTOSIS

🙐 NECROSIS

🙐 When this happens in epithelial cells, like the gut or the lining of the bladder, the result is a hole in the surface where the cell was, and this can make the tissue fail as a barrier.

🙐 This is how the death of intestinal cells can be part

of the reason behind the leaky gut.

How does this work ?

Excess oxalate’s disruption of calcium levels can harm the performance of cells that don’t get enough oxalate inside them to die, but they do get enough to affect cell chemistry.

​

The calcium that oxalate binds might have been used

to regulate the process of making vesicles that collect and then will release from the cell substances that were produced inside the cell.

How does this work ?

This effect of calcium may be

🙐 why those with genetic disease with excesses of oxalate don’t release enough growth hormone and require replacement therapy and

🙐 why when oxalate collects in the thyroid, the thyroid won’t release enough hormone to the body, causing a need for thyroid replacement therapy.

HIGH OXALATE FOODS

Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder: A Randomized, Controlled 12-Month Trial

James B. Adams 1,* ID , Tapan Audhya 2, Elizabeth Geis 1, Eva Gehn 1, Valeria Fimbres 1, Elena L. Pollard 1, Jessica

Mitchell 3, Julie Ingram 1, Robert Hellmers 4, Dana Laake 5, Julie S. Matthews 6, Kefeng Li 7, Jane C. Naviaux 7, Robert

K. Naviaux 7, Rebecca L. Adams 1, Devon M. Coleman 1 ID and David W. Quig, Nutrients 2018, 10, 369; doi:10.3390/nu10030369

10 months of

diet

&

4 months of

chelation

27 years old

BEFORE

AFTER

no consensus on nutrition !

Kinaci, Edelson, Shattock, Young & Geslak at dinner

FINAL DECISION !

ABA

🙐 Applied Behavior Analysis is

🙒 A series of techniques that help change behavior!

🙐 Everything we do is Behavior

🙒 Swallowing a pill is behavior

🙒 Eating food is behavior

🙒 Hitting people to get away from a shot is behavior

🙒 Crying to avoid an HBOT chamber is behavior

🙐 Behaviors can be good, bad or neutral

🙐 The way we classify behaviors is subjective!

🙐 Goal is to teach behaviors that are adaptive!

Occupational Therapy

🙐 Occupational therapists help individuals with an autism spectrum disorder improve both fine and gross

motor skills plus address sensory processing concerns.

​

🙐 An occupational therapist will work with an autistic person to develop skills for handwriting, shirt buttoning, shoe tying, and so forth Occupational therapy is a part of the autism treatment plan and is provided by an registered and licensed occupational therapist (OTR/L) or a certified occupational therapy assistant (COTA).

Sensory Integration

🙐 Sensory integration therapy is a type of occupational therapy (OT) that places a child in a room specifically designed to stimulate and challenge all of the senses.

🙐 Many autistic individuals have sensory problems, which can range from mild to severe. These problems involve either hypersensitivity or hyposensitivity to stimulation

🙐 Sensory integration focuses primarily on three senses

🙒 vestibular (i.e., motion, balance),

🙒 tactile (i.e., touch),

🙒 proprioception (e.g., joints, ligaments).

🙐 Many techniques are used to stimulate these senses in order to normalize them.

Sensory Integration

🙐 A sensory integration room is designed to make the child want to run into it and play .

🙐 During sensory integration therapy, the child interacts one-on-one with the occupational therapist and performs an activity that combines sensory input with motion.

🙐 Examples of such activities include:

🙒 Swinging in a hammock (movement through space)

🙒 Dancing to music (sound)

🙒 Playing in boxes filled with beans (touch)

🙒 Crawling through tunnels (touch and movement through space)

🙒 Hitting swinging balls (eye-hand coordination)

🙒 Spinning on a chair (balance and vision)

🙒 Balancing on a beam (balance)

Speech Therapy

🙐 This may be beneficial to many autistic children, but often only 1-2 hours/week is available, so it probably has only modest benefit unless integrated with other home and school programs. sign language and PECS may also be very helpful in developing speech.

​

🙐 Speech therapists should work on helping the child to hear hard consonant sounds such as the “c” in cup. It is often helpful if the therapist stretches out and enunciates the consonant sounds.

Floortime

🙐 Floortime is a treatment method and a philosophy for

interacting with autistic children.

​

🙐 It is based on the premise that the child can increase and build a larger circle of interaction with an adult who meets the child at his current developmental level and who builds on the child's particular strengths.

Floortime

🙐 The goal in Floortime is to move the child through the six basic developmental milestones that must be mastered for emotional and intellectual growth such as

🙒 self regulation and interest in the world

🙒 intimacy or a special love for the world of human relations

🙒 two-way communication

🙒 complex communication

🙒 emotional ideas

🙒 emotional thinking

​

🙐 The autistic child is challenged in moving naturally through these milestones as a result of sensory over- or under-reactions, processing difficulties, and/or poor control of physical responses.

Berard Auditory Integration Training

🙐 Berard Auditory Integration Training was designed to normalize hearing and the ways in which the brain processes auditory information.

🙐 For example, an individual tests as hypersensitive to the frequencies of 1,000 and 8,000 Hertz while perception of all other frequencies falls within the normal range.

🙐 The individual becomes overstimulated, disoriented or agitated in the presence of sounds at 1,000 and 8,000 Hertz.

🙐 Therefore, Berard AIT works to normalize the hearing response across all frequencies within the normal hearing range.

Berard Auditory Integration Training

🙐 In another example, an individual's hearing is asymmetrical (significantly different between the two ears).

​

🙐 When the right and left ears perceive sounds in an extremely different way, problems with sound discrimination can occur.

​

🙐 Again, Berard AIT works to normalize the hearing of both ears.

🙐Special

Education should always be included

in the biomedical

treatments.

🙐 Teachers are available to show you how to train your child.

​

🙐 What the child learns in school or preschool needs to be repeated at home and outside.

​

🙐 A few hours of training is never enough.

​

🙐 The child has a difficult time for generalizing.

ALWAYS FOLLOW THE CHILDS TRAINING

MONITOR THE CHILDS DEVELOPMENT

🙐 All institutes have the

responsibility to do

🙒 a yearly plan and

🙒 a 3 months performance plan.

🙐 This way it is easy to establish the childs development and how much he/she learns.

MAKE SURE TO WRITE IT ALL DOWN

🙐 The childs vaccinations, sicknesses (especially diarrhoea, constipation, vomiting, infections, fevers and similar), examinations, behaviour reports, developmental charts, etc.

🙐 Always carry a notebook and pen with you

so you can note all behaviour you judge as being important.

🙐 Otherwise it is easy to forget.

🙐 Most parents could use psychological support.

🙐 There are psychologists at all institutes.

🙐 But if the parents don’t ask for support it is doubtful that the psychologist can help.

🙐 While you’re learning how to care for your child, don’t forget to take care of your selves.

🙐 Accept, all the support you can get!

🙐 Autism is treatable.

​

🙐 Treatment is individual-specific.

​

🙐 Significiant gains are usual.

​

🙐 Temporary setbacks are common.

​

🙐 It’s never too late !

REMOVE

🙐SUGAR

🙐JUNK FOOD

🙐PRESERVATIVES

From your childs diet !

REPLENISH

with

🙐GOOD FLORA (PROBIOTICS)

🙐ENZYMES

🙐NUTRIENTS

🙐ESSENTIAL FATTY ACIDS

REPAIR

with

🙐Antifungals

🙐Antivirals

🙐Antibacterials

🙐Immunotheraphy

🙐Detoxification/Chelation

🙐HBOT

INTENSITY OF SYMPTOMS = INTENSITY OF TREATMENT