DEVELOPMENT OF A NON -INVASIVE GLUCOSE MONITORING PATCH

PRESENTED BY-

RANA MOZUMDER (1518009)

ANADIL FARUQUE (1518011)

Department of Biomedical Engineering, BUET

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Diabetic Patient of BD

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2016

2017

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Problems with conventional Glucose meter

Invasive

Need to prick the finger using Lancet to obtain glucose

Not Precise

Accuracy mostly depends on individual’s performance, also on the number of hematocrit, temperature, humidity etc

Non-continuous Monitor

Only can be used 2/3 times in a day as damages skin tissue

Storage Problem

Contains lancet, glucometer, bottle of test strips and tough to maintain as has short battery life and one time usable strips

Costly

Around 14-83$,prize varies according to model, each test strip is around .35-2$

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Our Product

Features of our product are:

Non-invasive

Don’t need to prick finger or blood

Continuous Monitor

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Can be used continuously at any time at any place

Precise

Accuracy is upto 90%

Easy to Use

Need no pre-calibration

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Design Considerations

1�Used transmission spectroscopy

• Measuring glucose concentration can be done by either transmittance or reflectance.
• Various experimental analysis shows that Transmittance will be much better.

2�NIR Transmitter of 1100 to 1850nm

• Near-infrared wavelengths in the ranges of 1100 to 1850 nm (overtone band) and 2050 to 2392nm (combination band) are more suitable.
• We have used LED1450E as transmitter.

3�Indium gallium arsenide Photodiode

• Has electromagnetic spectrum within 800-2600 nm wavelength.
•  Is a semiconductor device that converts light from transmitter into an electrical current. 

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NIR Transmitter

Photodiode

Computer

Noise Filter

Amplifier Circuit

Microcontroller

Schematic of our Design

Sample

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NIR Transmitter

Microcontroller

Operational Amplifier

Resistors

Capacitor

In-Ga-As Photodiode

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Basic Parts of our Product

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Transmitter Connection

LED 1450E

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Emits 1450nm NIR

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Can penetrate finger

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Circuit

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Receiver connection & Noise filter

FGA10 photodiode

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Has response range of 1200nm to 2600nm

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Receives the transmitted signal from finger

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Circuit

Used RC noise Filter

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Amplifier circuit

Op-Amp LM324

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Negative Feedback is applied

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Produced greater output signal

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Circuit

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Microcontroller

Arduino UNO

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Will supply power to run the circuit

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Work as the instructions given in the code

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Circuit

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Conventional

Glucometer shows result

in

mol/L unit

Normal Range

Is between

80-105 Mg/dl

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Results may fluctuate due to fasting / after eating

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Above 120 mg/dl indicates diabetes

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Output will be in millivolt range

We have to convert it in mg/dl

Problem

Equation!!

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Tests

• Calibrate with known concentration of glucose solution

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• Output for this glucose concentrations were identified

• Measure the concentration of patient’s blood glucose which was detected with conventional glucometer.
• Calibrated with our device

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Flow Chart of our Code

Takes the width of the finger

Sets a duration time

Sets a frequency

Takes reading after a certain period

Converts ADC value to millivolts

Calculates Glucose Level by the equation

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Cost

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195.15 $

Where other costs 499-1049$ !

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Product Limitations

Measurement

Can’t measure high blood glucose level

Not low costed

Price is quite higher than conventional glucometer, but lower than non-invasive meters

Not a Patch

We couldn’t make a patch cause we need nano technology and it may increase the price

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Future Goal

Of

Increasing the accuracy

• By applying two/three stage amplifier circuit
• To analyze data with various wavelengths of transmitter

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Multivariate regression analysis

• Should be done using matlab, excel and other softwares

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Making more handy

• By implementing semiconductors & nano-technology
• By making patch

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ANY QUESTION

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