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Aspirin FAQs

• What Dose of ASA? Maybe 162 mg per day

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• 2023 Systematic Review and Metanalysis of 4 studies n= 552
• Compared efficacy of 75-81 mg/day to 150-162 mg per day
• High risk patients
• Preeclampsia development was primary outcome in two of 4 studies, secondary outcome in other two
• Possible Bias, two studies unclear bias risk, one high risk, one low risk

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• Outcomes
• 3 studies n = 472
• Decreased risk of preterm preeclampsia RR 0.34 CI (0.12-0.79)
• Decreased risk for severe preeclampsia RR 0.23 CI (0.09-0.62)

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• 4 studies n = 552
• No difference in term preeclampsia RR 0.57 CI (0.12-2.64)
• No difference in total preeclampsia RR 0.42 CI (0.17-1.05)

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• Because of bias and small size, calls for larger high-quality studies

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