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Laboratory Committee meeting

Nov 21, 2024

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Welcome to the Laboratory Committee Meeting

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Agendas and other documentation can be found at loinc.org/committee/laboratory

If you have any issues or questions, please contact us at labcommittee@loinc.org

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Agenda

Time

Topic

Action

Lead(s)

9:00-9:05

Welcome

Informational

Pam Banning

9:05-9:10

SHIELD - Update

Informational

Andrea Pitkus

9:10-9:25

-HDS Requests (Cross match - Stan’s response)

-LOINC and microbiological diagnostics NAA

Informational/Discussion

Pam Banning/Stan Huff/Eza Hafeza/All

9:25-9:40

DRUG/TOX Method Updates

Discussion

Pam Banning/All

9:40-9:50

A few questions for clarification:

-IFCC (calibrators)

-Antibiotics XXX

Informational

Pam Banning/Andrea Pitkus

9:50 - 10:00

Discussion of open action Items

Discussion

Pam Banning/All

10:00

Closing and adjourn

Informational

Pam Banning

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SHIELD Update

By

Andrea Pitkus

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New Proposal - Micro Diagnostics NAA

New Proposal

LOINC and microbiological diagnostics NAA proposal

LOINC and Micro Diagnostics NAA

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HDS Requests - Cross-match (Question)

Original Question to Stan

…” Hello Stan!

The Lab LOINC Committee met today, and one very interesting topic came up for a blood bank crossmatch submission. This is regarding donors of blood products who are taking Daratumamub, and how might that coating on the red cells impact the interpretation of the crossmatch for the recipient (pan-reactivity during the test). Slides below are documentation to assist.

We compared components of blood group antibody screen (known red cell antigens against patient’s serum) with crossmatches (major and minor).

There are several reagents that can be used in blood bank to clear up interfering substances that don’t get listed in the final crossmatch availability.

There are also reagents (low ionic strength solution, polyethylene glycol for unspecific bindings can be used in the antihuman globulin phase), or conditions (prewarming for cold agglutinins) If you search.loinc.org for ‘crossmatch bldbk’ you’ll see the major and minor crossmatches and the methods that exist now.

The committee wanted to run this request by you for impact on post coordination and methodology. Let us know your thoughts when you have time.

Thanks!

Pam”

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HDS Request - Stan’s response (Cross-match)

I think post coordination would be a good approach for these kinds of information. That is, we would have the general codes for major and minor cross match, and then we would make a new LOINC code for “cross match method” (or some better name), and the items in the value set would be prewarmed, LISS, Electronic, pre spin, etc., and the new code with its value would be sent along with the cross match result. We would leave the existing pre coordinated codes as they are.

Maybe a different question is whether we need a way to communicate from the EHR to the lab the name of any drugs that the patient is on that could interfere with the crossmatch? Is that being handled already?

Thanks, Stan

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Drug / Toxicology

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Questions for Clarification

Revisit open items:

-IFCC (calibrators)

-Antibiotics XXX

By

Andrea Pitkus

Pam Banning

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Next Steps

  • Other topics

  • Next scheduled meeting : Dec 19, 2024 , 9:00-10:00 am ET

Agendas and other documentation can be found at loinc.org/committee/laboratory

If you have any issues or questions, please contact us at labcommittee@loinc.org