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Neoplasia 1�slides

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SQUAMOUS CELL PAPILLOMA, SKIN

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SQUAMOUS CELL PAPILLOMA

  1. A branching central core of connective tissue covered with a thick layer of stratified squamous epithelium, the core shows blood squamous epithelium.
  2. The core shows blood vessels and few inflammatory cells.
  3. The covering epithelium shows hyperkeratosis (thick keratin layer), acanthosis (thick prickle cell layer), parakeratosis (retained nuclei of the keratin layer) and basal cell hyperplasia.
  4.  

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THYROID ADENOMA

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THYROID ADENOMA

  1. A well- encapsulated benign tumour tissue consisting of closely- packed small follicles lined with cubical epithelium.
  2. Inside the capsule, some follicles contain colloid and some follicles are closely packed forming solid masses.
  3. Outside the capsule, there are normal thyroid follicles, regular uniform and filled with colloid, which appear totally different from the neoplastic tissue inside the capsule.
  4. There are compressed follicles within the capsule.
  5. No capsular or vascular invasion by the tumor cells

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Fibroadenoma

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Fibroadenoma of the breast

  • A well- encapsulated benign breast tumor composed of:
  • Compressed stretched proliferating breast ducts which appear star shaped and slit like over excess fine myxomatous connective tissue (intracanalicular pattern ) admixed with few oval or rounded ducts lined with one or multiple layers of cubical cells surrounded by flat myoepithelial cells (pericanalicular pattern )
  • The ducts are lined by two layers, outer flattened (myoepithelial cells) and inner cubical (ductal cells).
  • The intracanalicular pattern is the predominant pattern in this case.