Biopolymers
Polymers for bio-applications
-Medicine
-Biomedical devices (implant or non-implant)
ECM(extracellular matrix) contacting
Blood contacting
Process for developing biomedical devices
Regulation – GMP
-Good Manufacturing Process
-The guidelines recommended by relevant agencies.
-Agencies control the authorization and licensing of the manufacture
:food, beverages, cosmetics, pharmaceutical products, dietary supplements, medical devices
Drug for morning sickness
10,000 children suffered from deceases
Thalidomide scandal
Frances Oldham Kelsey
CardioMEMS (Abbott)
The only FDA approved implanted sensor
Blood contacting devices
Materials: Nitinol, silicone polymer
Maximum 3 years in body
Aspirin for life
Type | Applications |
PTFE (ePTFE) | vessel, heart valve |
Polyester (Dacron) | vessel, heart valve |
Silicon | heart, heart valve poppets |
Polyurethane | heart |
Implanted polymers
Dacron (PES)
Roughness and cell propagation
Surface tension and cell propagation
Gore-tex cardiovascular patch
Hydrogel
-Water + polymer = water like polymer
-nontoxic, 3d printable
-strong mechanics, toughness
-strong adhesion