COVID-19 Disease and �Treatments Overview

March 16, 2021

David Hartsuch, MD, MS

Rejuvagent Clinic

Davenport, IA

DHartsuch@gmail.com

�I am here today to encourage you all to get Vaccinated for COVID-19. ��Anything that I say today is intended to emphasize the idea that the COVID-19 vaccines are safe, effective, and necessary to combat this deadly disease.��I can say this with great assurance because licensing boards, and other credentialing bodies have made it clear that licensed and board certified physicians may be stripped of their right to practice for publicly saying false or misleading information.��Unless you want to see me detasseling corn in Iowa for the rest of my career,

Please Get Vaccinated!

Disclaimer:

What is the COVID-19 Virus?

The COVID-19 Virus is a Corona virus with a spike protein with a high binding affinity for the human ACE II receptor on cells.

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Pathophysiology �of COVID-19

Stages of COVID-19

1. Inoculation
2. Viral Replication
3. Sodium loss
4. Inflammation
5. Pulmonary Edema
6. Thrombosis
7. Death

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Inoculation

How is COVID-19 Spread?

COVID-19 is conventionally throught airborne spread.

(Mostly by the unvaccinated. Please get Vaccinated.)

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Despite the Certainty of this claim, Little scientific studies have confirmed the mechanism of spread

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CDC recommends :

Social Distance

Wear Masks

Get Vaccinated

Prevention You don’t hear about

COVID-19 is inactivated by:

UV light exposure

Chemical inactivation:

Chlorine such as bleach

Peroxide .5% solution for 1 minute

Alcohol > 50% concentration

Weak bases (pH > 8)

Sodium Bicarbonate (5% solution = 1 tsp per 100 cc water)

Sodium Carbonate

Ozone (may be harmful to humans)

UV and Ozone devices

Improving Host Defenses

Improve adaptive immunity through:

1. Zinc
2. Vitamin D
3. Weight Control
4. Exercise
5. Sleep
6. High flavonoid / Polyphenol diet

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Reduce the number of ACE II receptors on cells by increasing salt intake.

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Viral Replication Phase

1. The Virus binds to the ACE II receptor of certain cells.
2. The Virus then uses the Cells organelles to create new viral particles.
3. These then get dispersed to infect other cells.
4. This process of viral replication is generally exponential.
5. Vaccination Can give your body a head start. (get Vaxed!)

Inhibitors of Viral Replication

• Prescription Drugs
• Hydroxychloroquine
• Ivermectin
• Indomethacin
• Remdesivir
• ETC.
• Anti-Body therapy
• Vaccination
• Monoclonal Antibodies
• Recovered Donor Plasma

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• Supplements
• Zinc Fingers
• Resveratrol
• Quercetin
• L-Lycine
• Vitamins C, E, folate
• Most Bioflavonoids

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Sodium Dysregulation

• ACE II causes the body to resorb sodium in order to keep the blood pressure up.
• Cells with ACE II receptors generally are responsible for actively retaining sodium in the Body
• Cells in the pituitary gland secrete Anti-diuretic hormone and are responsible for water retention.
• Cells in the lungs keep alveoli dry and able to exchange oxygen.

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Distribution of ACE II Receptors

• Widely distributed including:
• Kidneys
• Sweat glands
• Salivary glands
• Adrenal glands
• Blood vessels
• Tear ducts
• Pituitary Gland

End Results of Sodium Dysregulation

• Weight Loss
• Headache
• Heavy Sweating
• Fatigue
• Salty / Metallic taste in the mouth
• Anorexia / Decreased Thirst
• Watery eyes
• Syndrome of Inappropriate Diuretic Hormone (SIADH)
• Early hyponatremia / Late hypernatremia
• Pulmonary Edema

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Pulmonary Sodium Regulation

Yale Data Collected

Early Sodium Treatment

• The Best gauge of Sodium Loss is Weight
• Most patients lose 1-3 lbs. of weight per day
• More severe weight loss corresponds to worse pulmonary course
• 1 lb. of weight loss is approximately 1 tsp of salt lost
• Effects of Early intervention with Sodium
• Reduces fatigue
• Prevents hypotension
• Increases available body sodium stores
• Downregulates the expression of ACE II receptors on Cell surfaces
• Contraindications
• History of Heart Failure
• Hypertension
• Vomiting or diarrhea

Signs of Inflamation

• Fever
• Chills
• Myalgia
• Headache
• Delerium

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Anti-inflammatory Agents

• Drugs
• Steroids (Prednisone, Dexamethizone, Methyl Prednisolone, Budesinide, etc.)
• Non-Steroidal Anti-Inflammatory
• Aspirin
• Ibuprofen
• Indomethacin
• Colchicine
• Baricitimib
• Supplements
• N-Acetyl Cysteine (NAC)
• Anti-oxidants
• Vitamin C
• Flavonoids

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Pulmonary Edema

• May result from inactive sodium pumps in apical cells, or inflammatory cells causing inflammation in the alveoli.
• Results in reduced Oxygenation and may be life threatening
• Go to the hospital if your pulse oximeter is < 92% on Room Air.

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Steps to Improve Oxygenation

• Frequently Cough and Deep Breath
• Breath with pursed lips
• Stay upright rather than laying down.
• Try sleeping on your stomach rather than back
• Bronchodilators and steroids may help.
• Go to the hospital if pulse oximeter is < 90%

Thrombosis

Thrombosis are blood clots that are formed in response to oxidative injury to tissues.

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They can result from endothelial injury to vessels, or the result of excessive viral infection through the activation of compliment.

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May be the result of platelet aggregation.

Anti-Thombotic Agents

• Heparin
• Coumadin
• Xeralto
• Elaquis
• Aspirin
• Indomethacin
• Bromolain

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Question:

You’re stranded on a deserted island and caught COVID-19 from a local fruit bat. Naturally, you have enough COVID-19 vaccine to take your weekly required boosters for the rest of your life.

After your life saving COVID-19 vaccine which of the following agents would you like as a second line agent?

1. Salt Water
2. Hydroxychloroquine
3. Ivermectin
4. Indomethacin
5. Heparin

Oral Rehydration Fluid�

• 1 L Water
• 1 tsp Sea Salt (contains 250 mg of Magnesium)
• 1 tsp Sodium Bicarbonate

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Drink over 8 hours

COVID-19 shopping list

• Zinc
• Vitamins C,D,E
• Sea Salt
• Sodium Bicarbonate
• Resveratrol
• L-Lysine
• Quercetin with Bromolain
• Green Tea and Green Tea Extract
• Cocoa Powder
• Pulse Oximeter
• Gelatin, Tapioca, popsicles, ginger ale, etc.

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Conclusion

• Seek Early Treatment with anti-virals and Sodium
• Monitor Weight Loss
• Prepare in advance
• Increase sodium intake in advance
• Go to the hospital if pulse ox < 92%
• Get Vaxed!

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Questions?