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Neoplasia II

Pathology Department

Practical Session

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Histopathology

Slides

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Basal cell carcinoma

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Basal Cell Carcinoma

(BCC, rodent ulcer)

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Definition: Locally malignant tumour arising from the basal cell layer of the epidermis of the skin and its appendages as hair follicles

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Sites of origin: occur in skin exposed to sun (middle third of the face)

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Mode of growth: slowly infiltrating, invading and destroying the surrounding structures till the bone but does not produces distant metastasis

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Basal Cell Carcinoma

(BCC, rodent ulcer)

Microscopic picture:

The dermis is infiltrated with masses of malignant epithelial cells forming nests of blue coloured cells characterized by:

-An outer columnar basal cells arranged in palisading (parallel) manner.

-An inner group of polyhedral, round, or spindle.

-the cells exhibits the criteria of malignancy….

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Squamous cell carcinoma

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Squamous Cell Carcinoma (SCC)

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Definition: Malignant tumour of stratified squamous epithelium.

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Sites of origin: Skin, lip, pharynx, larynx, esophagus, anal canal, vagina and cervix. It occurs also on top of squamous metaplasia.

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Predisposing factors for SCC:

1- Chronic irritation. 2- Chronic exposure to sunlight.

3- Radiation. 4- Leukoplakia.

5- Seborrheic keratosis. 6- Papilloma and squamous metaplasia.

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Malignant ulcer

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The tumour is composed of:

  • Sheets and cords of malignant squamous cells (keratinocytes) invading the dermis with variable number of cell nests �(keratin pearls) surrounded by desmoplasia.
  • The cells show malignant characters (mention).
  • The stroma is infiltrated by chronic inflammatory cells.

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Adenocarcinoma, colon

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The tumour Shows:

  • Infiltration of the submucosa and musculosa by malignant glands:

1- Basophilic 2- Irregular 3- Variable in size and shape 4- Show depletion of goblet cells.

  • The glands are lined with malignant cells (Mention the malignant characters).
  • Compare with normal colonic glands: �1- Regular 2- Uniform 3-lined with one layer of columnar cells 4- Mucin secreting

Adenocarcinoma, colon

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adenocarcinoma (colon)