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Welcome! �COVID-19 pathway analysis workshop

Nhung Pham

Department of Bioinformatics (BIGCAT), Maastricht Centre for Systems Biology (MACSBIO)

Maastricht University

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5 July 2022

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Who are we?

Organizers

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Instructors

Susan Steinbusch-Coort

Martina Summer-Kutmon

Nhung Pham

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Who are we?

Organizers

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Instructors

Susan Steinbusch-Coort

Martina Summer-Kutmon

Nhung Pham

And you!

22 participants

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ZonMw COVID19 project

  • WikiPathways as a platform for COVID-19 biological pathway models

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  • Started in Sept 2020
  • 2-year project

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  • Project focus
    • Pathway curation
    • Tool development
    • Analysis workflows

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The COVID-19 portal on WikiPathways

https://www.wikipathways.org/index.php/Portal:COVID-19

Viral entry and life cycle (WP5076, WP5113, WP5156, WP4883, WP4799)

Host immune response: type 1 IFN (WP4868), innate (WP5039), adaptive (b cells WP5218; t cells WP5098), complement (WP5148)

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Viral- host responses (WP5145, WP5027, WP4884, WP4861, WP4936, WP4876, WP4877, WP5115)

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Until 05-07-2022: 42 pathways

Others role of Vitamin D (WP5133), mRNA vaccine activation of dendritic cells (WP5187), linoleic acid metabolism (WP4853), other human coronaviruses (WP4880, WP4912)

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COVID-19 Disease Map Project

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Workshop information

Slack channel

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Github page: https://bigcat-covid19.github.io/Workshop-July2022/

Zoom link

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Program

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Day 1: Pathway curation

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Program

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Day 1: Pathway curation

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Day 2&3: Pathway and network analysis

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Today Program

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10.00 - 10.30

Welcome - introduction to the COVID-19 project and the workshop

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10.30 - 11.15

Lecture: Introduction to pathway models (databases), WikiPathways and PathVisio

11.15-12.00

Hands-on - WikiPathways academy

12.00-13.00

Lunch

13.00-16.00

Hands-on: draw your own pathway

Select one from our list or a pathway of your interest

16.00 - 17.00

Lecture: Ending with the importance of curation and Q&A

17.00 - 21.00

Social event & Dinner

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Questions?