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IMAG/MSM Working Group on Multiscale Modeling and Viral Pandemics Mini Seminars

Jan 27, 2022

Welcome - The meeting will start at 3PM ET

 

NOTE: THE MEETING WILL BE RECORDED, STREAMED AND PUBLICLY AVAILABLE�FOR THOSE MEMBERS UNABLE TO ATTEND

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Agenda

  1. Welcome
  2. Links, people, other info
  3. Social media links
  4. Quick Announcements
  5. Upcoming Mini-Seminars and Request for Future Speakers
  6. Stacey Smith?, University of Ottawa. Title: Is a COVID-19 Vaccine Likely to Make Things Worse?
  7. Vivek Kapur, Pennsylvania State University.
  8. Request for Further Business

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People

Co-Lead: Reinhard Laubenbacher, PhD

Department of Medicine

Laboratory for Systems Medicine

University of Florida

reinhard.laubenbacher@medicine.ufl.edu

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Co-Lead: James A. Glazier, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jaglazier@gmail.com

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Web Administration, Slack: James P. Sluka, PhD

Dept. of Intelligent Systems Engineering and Biocomplexity Institute

Indiana University, Bloomington

jsluka@indiana.edu

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Activities Coordination: Lorenzo Veschini, PhD

King’s College London

lorenzo.veschini@gmail.com

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Please follow the�group on Twitter!

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https://twitter.com/MsmViral

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If you could re-tweet the weekly announcements �(there are usually two, one for each speaker) �that would help boost attendance and community awareness.

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Announcements

�Any short (~1 minute) items such as;

  • announcements
  • meetings
  • funding
  • publications
  • requests for help
  • ???

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Schedule for Upcoming Meetings and mini-Seminars

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Feb 3:

  1. Hana Dubrovolny, Texas Christian University. Title: Modeling viral coinfections of the respiratory tract.
  2. TBD

Feb 10:

  1. Kevin Janes, University of Virginia. TItle: Stress testing complete kinetic models of individualized enteroviral infection
  2. William Waites, University of Edinburgh, U.K. (tentative)

Feb 17:

  1. Juliano Gianlupi, Indiana University, Title: Coupled PK model of an antiviral and agent-based model reveal the importance of inter-cellular metabolism heterogeneity on treatment outcomes
  2. TBD

Feb 24:

  1. Hayriye Gulbudak, University of Louisiana at Lafayette. Title: Coupled systems that have in-host and between-host components for various infectious diseases.

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Request for future speakers (Feb 3, …)

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Rules of the Meeting

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Please mute your microphone and hold questions until after the presentations

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Mini-Seminar�Is a COVID-19 Vaccine Likely to Make Things Worse?

Stacey Smith?�University of Ottawa

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In order to limit the disease burden and economic costs associated with the COVID-19 pandemic, it is important to understand how effective and widely distributed a vaccine must be in order to have a beneficial impact on public health. To evaluate the potential effect of a vaccine, we developed risk equations for the daily risk of COVID-19 infection both currently and after a vaccine becomes available. Our risk equations account for the basic transmission probability of COVID-19 (β) and the lowered risk due to various protection options: physical distancing; face coverings such as masks, goggles, face shields or other medical equipment; handwashing; and vaccination. We found that the outcome depends significantly on the degree of vaccine uptake: if uptake is higher than 80%, then the daily risk can be cut by 50% or more. However, if less than 40% of people get vaccinated and other protection options are abandoned—as may well happen in the wake of a COVID-19 vaccine—then introducing even an excellent vaccine will produce a worse outcome than our current situation. It is thus critical that effective education strategies are employed in tandem with vaccine rollout.

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Mini-Seminar�

Vivek Kapur,�Pennsylvania State University

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Requests for Input/Suggestions

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We would like the subgroup leads to prepare brief presentations for the Thursday meetings, please let us know when you would like to present

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Ideas/help for publicising our Thursday mini-seminars more effectively and for speakers to invite

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Suggestions for agenda items and approaches to organizing the Steering Committee Meetings more effectively

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There have also been a number of requests for more explicit statements of goals and tasks from the WG leadership, we would appreciate your suggestions

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Please contact Reinhard Laubenbacher, James Glazier, James Sluka or Bruce Shapiro with your ideas on all of these issues

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