Biomaterials

Class introduction

1. Midterm, final (30% each)�2. H.W. (20%)

3. Presentation (10%)�4. Class participation (10%)

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We will do experiments!!

Biomaterials and Polymers

1. Basic Structure

• Polymers: Large molecules made up of repeating monomer units. They can be natural (e.g., cellulose, proteins) or synthetic (e.g., polyethylene, polylactide).
• Biomaterials: Materials designed to interact with biological systems. Many biomaterials are polymer-based (either natural or synthetic).

2. Functional Properties

• Biocompatibility: Polymers with low immune rejection are widely used in biomaterials such as artificial organs, sutures, and drug delivery systems.
• Processability: Polymers can be engineered to have specific mechanical strength, degradation rates, and surface properties. This tunability is crucial for designing biomaterials as well.

Structures

DNA, RNA, Proteins

Synthetic polymers

Polymerization methods

Step, ionic, radical polymerizations

DNA? RNA? Protein?

2001 Nature

DNA sequencing

Sanger method

Hydrogen bonding

DNA structure

Pi-stacking of DNA

RNA degradation

DNA backbone

RNA backbone

Open deoxyribose chain structure

DNA structure

ATP: Adenosine triphosphate

30.5kJ/mol

DNA->RNA

RNA->protein

Silk

Wool

RNAi : RNA intereference

RNA polymerase

Conventional method for prediction of protein structures

Protein Data Bank: https://www.rcsb.org/

Lipid

Collagen

Glycine, proline, hydroxyproline

Nafion

Can we synthesize biopolymers?

Or can we replace biomolecules with artificial molecules?

Or can you bring the insight of biomolecule into polymers?

Syntheric polymer

Biopolymer

Biocompatibility

Biomaterials

Metal

Titanium

STS

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Polymer

PU

PLA

PMMA

PES

PTFE

Carbon

Silicone

Polysulfone

Nylon

Hydrogel

PP