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Biocompatible polymer

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Class introduction

Midterm, final (30%)
Class participation (70%)

Review on polymer chemistry (synthesis) + molecular structure (configuration, conformation)

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Conformational isomer

Configuration�same molecular formula

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Molecules

Carbon, oxygen, sulfur, hydrogen ..

configuration

conformation

Functions!!

X-ray, NMR …

Prediction (AI)

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Biomaterials and Polymers

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1. Basic Structure

Polymers: Large molecules made up of repeating monomer units. They can be natural (e.g., cellulose, proteins) or synthetic (e.g., polyethylene, polylactide).
Biomaterials: Materials designed to interact with biological systems. Many biomaterials are polymer-based (either natural or synthetic).

2. Functional Properties

Biocompatibility: Polymers with low immune rejection are widely used in biomaterials such as artificial organs, sutures, and drug delivery systems.
Processability: Polymers can be engineered to have specific mechanical strength, degradation rates, and surface properties. This tunability is crucial for designing biomaterials as well.

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Structures

DNA, RNA, Proteins

Synthetic polymers

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Polymerization methods

Step, ionic, radical polymerizations

DNA? RNA? Protein?

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2001 Nature

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DNA sequencing

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Sanger method

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Hydrogen bonding

DNA structure

Pi-stacking of DNA

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RNA degradation

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DNA backbone

RNA backbone

Open deoxyribose chain structure

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DNA structure

ATP: Adenosine triphosphate

30.5kJ/mol

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DNA->RNA

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RNA->protein

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Silk

Wool

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RNAi : RNA intereference

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RNA polymerase

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Conventional method for prediction of protein structures

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Protein Data Bank: https://www.rcsb.org/

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Lipid

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Collagen

Glycine, proline, hydroxyproline

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Nafion

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Can we synthesize biopolymers?

Or can we replace biomolecules with artificial molecules?

Or can you bring the insight of biomolecule into polymers?

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Syntheric polymer

Biopolymer

Biocompatibility

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Biomaterials

Metal

Titanium

STS

Polymer

PLA

PMMA

PES

PTFE

Carbon

Silicone

Polysulfone

Nylon

Hydrogel