Bioactivity

Δ⁹-THC Acute

Psychotropic/Getting High: sensory awareness, euphoria, intoxication

Δ⁹-THC Chronic

Examples: CUD and Memory impairment

Bioactivity

CBD Acute

Cognition, Reduce THC psychoactivity, Other drug interactions?

CBD Chronic

Brain anatomy and liver toxicity

Cannabinoids

• Phytocannabinoids: produced by plant
• Endocannabinoids: produced by body
• Artificial cannabinoids: Not produced by nature (e.g., plant or another organism)
• Synthetic cannabinoids: Synthesized in the lab (e.g., Δ⁹-THC and CBD).

Pharmacology

Potency = bioactivity: Treatment dose 🡺 Concentration in tissue (e.g., brain) + Activity at target (e.g., CB₁R).

Chemical structure versus Bioactivity.

Current understanding of some fundamentals in Cannabis Research

My questions:

What is the nutritional value of CBD and how much is needed?

Why would “CBD gummy bears to help sleep” be regulated as Food instead of a Nutraceutical or Medicine?

How are food products that contain bioactive compounds regulated (e.g., Vitamin C, Capsaicin)?

What are the basic FDA criteria for food safety?

When did CBD levels increase in products that were consumed as most use of Cannabis had high THC/low CBD?

Failed crops: Route of destruction? Foster recycling?