��Medical Device From Chula 1997-2022

Tayard Desudchit, Md

Cherdkul Sopavanich

Chotsak Kulkitiyakorn

Pished Bunnin

Kanawat Senanan

Thaweesak Talthipwan

Pornlert Chatkraew,MD

Tawatchai Sarntipipat,MD

Suntchai Wirotsaengthong,MD

Ukrit Meukchit

Apichai Khongpatanayothin MD.

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Medical Device From Chula 1997-2017

• Most devices/ Projects are started as students / residents projects
• Funded by
• Ratchadabhiseksompoj Fund
• NRCT
• Self-fund

• EEG/PSG
• Bililight
• Portable ECG
• Pulse oximeter(NRCT)
• Bedside Monitor & Vital-sign Tele-medcine(NRCT)
• Defibrillator(NRCT)
• Uro-flow meter
• OSLER
• SOS
• ANES-Train of Four(Royal Col. Anes)
• Portable Sleep Screener
• TRCS-HighFlow (Intronic)
• Transport Ventilator (NRCT)

EEG 1997-2000

• 1997 : 4^th year Engineering Sutdent Project, continue in 1998 & 1999
• Validated 1999 @Chula
• Ratchadbhisek Sompoj Fund & The Supporting Funds for The Electrical Engineer Students
• 1^St price NRCT 2000
• Engineering Colleagues
• Cherdkul Sopawanich
• Manop Wonsaisuwan
• Kongpop U-Yen
• Manisa-U-Yen
• Kanawat Senanan
• Taweesak Thanthipwan
• Pished Bunnun

EEG-PSG 2000-2005

• 4 Machines sales 2005-2007
• Linux/Window operating system
• 2/4 still operational
• All Manual assembly / Multiple discrete parts

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EEG-PSG Present

• USB power, IEC 601.1
• Surface mounted, Factory asembly
• Complete from electrodes, amplifier, effort belts, thermistor, pressure air flow & CPAP titrator, Bodyposition, SpO2 & ETCO2

In use in

Government Hospitals

• ICU EEG Monitor : Cardiac ICU ราชวิถี, รพ.สรรพประสิทธิประสงค์ อุบลราชธานี
• PSG : วชิรพยาบาล, รพ.โรคทรวงอก, รพ. ตำรวจ,
• Software : PSG exam SST 2010,2011

Private Hospitals

• EEG: Vibharam, PYT2
• PSG: Chaophraya, ENT, PYT2, RAM, Rajthani, Ruma-Pathe, SMV, Synpathes, Sukumvit,Ubolrak Vibharam, Vibhawadee,
• Lamdong Medical College, Vietnam

A Comparative Study, Efficacy of Phototherapy for Treatment of Neonatal Hyperbilirubinemia: �LED vs Fluorescence

Tawatchai Sarntipipat, MD

Tayard Desudchit, MD

Pimolrat Thaithumyanon, MD

Department of Pediatrics,

Faculty of Medicine, Chulalongkorn University

Phototherapy

การวัด Spectrometer [Wavelenght]�ที่คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย�ดร. สนอง

Fluorescence

LED

Randomized Controlled Trials�LED vs Fluorescence Phototherapy

Patient outcomes

Simple randomization

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70 cases

LED

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70 cases

Fluorescence

Clinical practice guideline

KCMH

Treatment

Term infants with

jaundice

Exclusion criteria

ABO or Rh incompatibility

DIC

Hematoma

Respiratory distress

Emergency problems

*Study Protocol: IRB No. 332/53, January 1^st-December 15^th, 2011

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1° : bilirubin decreasing rate

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2°: duration of phototherapy

LED reduced bilirubin faster than traditional fluorescent phototherapy unit

13.31±1.30

13.30±1.32

p-value=0.96

10.80±1.36

9.78±1.31

Bilirubin level (mg/dL)

0.09±0.06mg/dL/hour

0.14±0.06 mg/dL/hour

*p-value<0.001

12.5

10

7.5

5

2.5

0

10

20

30

Time (hours)

*p-value<0.001

24.09±3.36 hours

26.27±7.37 hours

*p-value 0.027

LED

Fluorescent

Custom built LED�phototherapy

�YOUNG INVESTIGATOR AWARD 2012

THE ROYAL COLLEGE OF PEDIATRICIANS OF THAILAND

> 600 Units in Thailand

Accuracy of MDCU portable ECG �compare with standard 12 leads ECG�at King Chulalongkorn Memorial Hospital

Tawatchai Sarntipipat, MD

Tayard Desudchit, MD

Apichai Khongphatthanayothin, M.D.

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What is This?

CPU + VGA +

Mainboard + RAM + etc.

Portable ECG with tablet or smartphone

ADS1298 + PSOC5-> USB

• ADS1298 + PSOC5
• USB power
• Isolated USB (ADUM- by analog device)
• Calibrated with Fluke ECG calibrator
• Record as EDF
• Display via EDF Viewer/ECG Viewer software
• Clinically Validated

2.Comparative study Accuracy of ECG�Portable ECG Vs Standard ECG

ECG wave parameter

Standard 12 leads ECG

[Mortara]

Portable 12 leads ECG

[ADS1298FE]

Amplitude [mm.]

Amplitude [mm.]

Duration

[msec]

Duration

[msec]

Investigation

[Diagnositc test]

Patients at

Pediatric cardiology ward

Compare Mean between 2 groups with

Paired t-test

Agreement of Test

Conclusion

• MDCU Portable ECG had a good accuracy as well as Standard ECG machine[Mortara instrument ELI250]

at King Chulalongkorn Memorial Hospital.

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Mortara instrument

ELI 250

Price 3,400-4,000 USD

MDCU Portable ECG

Price 350-500 USD

Discussion: apply for Holter or Even recorder

• Portable ECG device or machine which you can picked up everwhere.
• Use as Holter monitoring[24 Hours-more than 30 days]
• Use as Event recorder, Loop cycle event recorder for ECG.
• Combine with other monitor as Vital sign monitor
• Combine with Polysomnography test
• Apply for Real time telemonitor ECG. Via internet, Wifi, 3G or 4G

Uroflow Meter

Validation

• With Standard know flow compare to commercial uroflow meter
• Then with patients in clinical validation

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Biphasic Portable �External Defibrillator

Nipon Chattipakorn, Tayard Desudchit, Cherdkul Sopawanit, Apichai Khongpattanayothin

การทดสอบทางไฟฟ้า (Electrical Signal Test)

• โครงการได้ทดสอบโปรแกรม Touch Screen Portable Vial Sign Monitor for Local/Remote ซึ่งเชื่อมต่อกับ Modules ต่าง ๆ ผ่านทาง Serial & USB Port เพื่อ นำ ECG wave, HR, SpO2. PR, และ Plethmogram wave ที่ได้มาแสดงผลบนจอ โดยใช้ Fluke Index II SpO2 Tested และ Fluke Impulse 7000 DP ECG/Defibrillator Tester กำเนิดสัญญาณ พบว่าสามารถรับและแสดงผลการวัดได้ถูกต้อง ตามคุณสมบัติของ Module แต่ละตัว

ECG Connectors

• A) ภาพแสดง EKG/Chest impedance electrodes ที่ใช้ในการทดสอบกับคน B) การต่อเชื่อมกับเครื่อง Fluke EKG Simulator

• Test with Fluke Impulse 7000 DP
• Can detect HR 10-254 BPM
• Amplitude .05-5 mV
• Detect on the rising edge of R wave- 2mm after the peak of R wave

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Waveforms

ผลการวิจัย(Results)