Pharmacokinetics || Midterm
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Q1. A drug solution has an initial concentration of 700mg/ml. After 5 months in a cold room, theconcentration was found to be 140 mg/ml.

Q1.A) Assuming first order decomposition, what isthe decomposition half-life (in months) of the ofthe original drug solution (C0)?
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Q1.B) Assuming zero order decomposition, what isthe decomposition half-life (in months) of the ofthe original drug solution (C0)?
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Q2. The decomposition half-life of a drug is 20 days at an initial concentration of 500 mg/L.

Q2.A) Assuming first order decomposition, what is the concentration after 36 days?
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Q3.The decomposition half-life of a  drug is 45 days at an initial concentration of 500 mg/L.

Q3.A) Assuming first order decomposition, what is the concentration after 72 days?
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Q3.B) Assuming zero order decomposition, what is the concentration after 72 days?
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Q4)A drug suspension decomposes upon storage at room temperature. Drug amount over time is presented in the table below
Q4.A) The decomposition of this drug follows
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Q4.B) The decomposition rate (in mg/day) when :the amount equal to 160 mg is *
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Q4.C) The decomposition half-life (in days) when the amount equal 160 mg is: *
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Q4.D)  Initial amount of the drug (in mg) *
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A 10mg dose of a new drug was given IV to the voluntary subject in a phase I clinical trial. The volume of distribution of the drug turned out to be 80litter. which of the following would have been (in litter) the volume of distribution of the drug, if the administered dose were 20 mg *
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  Doubling the rate of infusion will result in doubling of the steady state conc. of the drug.
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The same dose of difference drugs was administered IV to the same lab animal on four different occasions. The following pharmacokinetic data were obtained: 
Drug Cpo(ng/m1)
A---25
B--- 12
C--- 44
D--- 90
Which of the following drugs will have the lowes t Vd? 
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  Following initiation of a constant rate IV infusion, after 1 half-life, 1/2 of steady- state level is reached.   
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The apparent volume of disribution is:  *
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 if -----(rate into tissue> rate out of tissue), tissue drug concentration will increase and plasma drug concentration will decrease   *
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  Bob is a 65 year old man on amiodarone therapy for chronic atrial fibrillation. He arrives in your clinic complaining of symptoms of hyperthyroidism, one of the many forms of amiodarone toxicity. A blood sample confirms a drug level of 4 ug/ml, well above his normal range of about 1 ug/ml. The half- life of amiodarone is 25 days. If you discontinue his medication, how long will you have to wait for Bob's amiodarone level to fall to anormal level of 1 ug/ml?   
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After administration of a single iv bolus dose of 150 mg lidocaine, the plasma conc-time profile can be describe by the following expression Cp=10e^-(0.5 t) +15e^ -(0.4 t) where t is in hours and Cp is in mg/L. Which of the following equations will describe lidocaine plasma conc-time profile after a single iv bolus dose of 300 mg lidocaine? 

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  A drug which follows first-order kinetics was given by IV infusion at a rate of 5 mg/min. The resulting mean steady-state plasma concentration was 50 mcg/mL. Which of the following would be (in mL/min) the total clearance of the drug?    *
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  In IV infusion, the ideal loading dose is the bolus dose that produces initial concentration equal to the desired steady state concentration Select one:  
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  The two-compartment model DOES NOT have Instantaneous distribution to most body tissues and fluids   
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  In two-compartment model, impaired cardiac function Will Not produce a change in blood flow and these affect the drug distributive phase   
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  Calculate the drug concentration 2 hours after discontinuation of a continuous IV infusion for 6 hours of 200 mg/hr has been administered to a patient. Assume a one compartment pharmacokinetic model. The V and elimination rate constant values for this drug are 62.7 L and 0.129hr^-1 respectively   
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  A patient was admitted to the hospital because of acute myocardial infarction. He was given an iv loading dose of 150 mg lidocaine followed immediately by a constant rate iv infusion of 2 mg/min. What is the rate of lidocaine elimination at steady state?   
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  A 70 kg man with severe burns arrives in the Emergency Department and requires i.v. morphine to treat his pain. The Vd for morphine is 200 L. What iv. loading dose do you need to give to rapidly achieve a therapeutic level of 60 ng/ml! and relieve his pain?   
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