1. Speaker: Dr. 정현우 Hyun-Woo Jeong(Max-Planck Institute for Molecular Biomedicine, Germany)
2. Topic: Specialized Vascular Endothelial Cells: Lessons from Single-Cell Transcriptomics
3. Date/time: 2023 Aug-02 / 1530-1530 (KST)
4. Place: Online (※ A Zoom address will be sent to your email and mobile number before the lecture begins.)
5. Abstract

Since the first single cell RNA-seq study was published in 2009, single cell transcriptomics /
multi-omics has been established as a key technology to understand the heterogeneous
cellular composition, functional transition or specificity, and dynamic molecular changes of
various biological samples, and is being utilized very actively in all fields related to biology
and medicine. In this presentation, I will demonstrate recent studies identifying functionally
and structurally specialized vascular endothelium in bone marrow microenvironment and
brain parenchyma. Using the single cell RNA-seq approach, we revealed that arterial
endothelial cells in fetal bone marrow have a crucial role for the initial expansion of
hematopoietic stem and progenitor cells. In murine cerebral cortex, we identified reactive
endothelial venules, a compartment of specialized postcapillary endothelial cells that are
characterized by consistent expression of cell adhesion molecules, preferential leukocyte
transmigration, association with perivascular macrophage populations, and endothelial
activation initiating immune responses in the central nervous system. These results provide
novel insights into the heterogeneity of the vascular endothelium in different organs and a
useful resource for the organotypic specialization of blood vessels during development and
inflammation.