Drug Inspector Mock Paper
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Question 1
If mean AUCÕs(ng.hr/mL) of drug dose1mg; for tablet; oral solution and IV are 0.90; 0.87 & 101.0 respectively. Calculate the absolute bioavailability of tablet form (1 point ) *
Question 2
Gastric emptying is slowed by all of the following EXCEPT (1 point ) *
Question 3
The Wurster process is used for (1 point ) *
Question 4
Hansen-padel equipment is used for (1 point ) *
Question 5
Base adsorption in capsules helps in determining (1 point ) *
Question 6
In UV visible Spectroscopy. Radiation Source may be (1 point ) *
Question 7
After placement of Aniline in to acidic solution its lemda-max reduced from 280 nm to 203 nm. This phenomenon will be call as (1 point ) *
Question 8
An IM injection site suitable for a small child (less then 3 years of age) is the (1 point ) *
Question 9
As per IP which statement is true for Type II glass (1 point ) *
Question 10
Primary amines show
P) Two N-H stretching bands in the range of 3500-3300 cm-1
Q) only band in the region 3500-3300cm-1
R) –NH band in primary amines results in a broad band in the region 1640-1560 cm-1
S) the typical –NH2 stretching value at 1715 cm-1 (1 point ) *
Question 11
Morphine is treated with –CH3I in aqueous KOH gives (-) codeine, which is not
soluble in alkali; codeine can be oxidized with chromic acid to acid to codeinone.
Which group is responsible for oxidation? (1 point ) *
Question 12
Pyrroziline heterocyclic ring system is present in one of the following drug (1 point ) *
Question 13
Coacervation phase separation technique is used for (1 point ) *
Question 14
Iontophoretic Drug Delivery systems is activated by (1 point ) *
Question 15
The release of drug from Sustained Released formulations can be explained by (1 point ) *
Question 16
Transdermal Drug Delivery systems is characterised by (1 point ) *
Question 17
Choose the correct statement regarding Pharmaceutical Aerosol
(a) Propellants are generally Low-vapor-pressure CFCs and HFAs
(b) 1,1,1,2-Tetrafluoroethane is also known as HFC-134a
(c) A collet is used to crimp the valve to the top of the aerosol container (1 point ) *
Question 18
Deuterated solvents are used to take NMR spectra because (1 point ) *
Question 19
Cinnamon consists of the inner bark of the shoots of coppiced trees of cinnamomum
Zeylanicum Nees. The typical microscopic characters of the bark are (1 point ) *
Question 20
Choose the statement which is not true
(a) Anhydrous form is more soluble than hydrous form
(b) Non solvated form is more soluble than solvated form.
(c) Increase the lubricant concentration, increase the hardness hence increase the disintegration time
(d) For highly soluble & less permeable drug, membrane absorption is rate limiting step (1 point ) *
Question 21
Choose the correct statement
(a) The use of low-dose methotrexate in the treatment of rheumatoid arthritis is most frequently used for pregnant women, since it is the DMARD with the least fetal toxicity
(b) Etanercept is a recombinant fusion protein consisting of two TNF receptor domains linked to one
IgG Fc molecule.
(c) Infliximab inhibit TNF-β (1 point ) *
Question 22
A mass spectra is showing a peak on 91 corresponding compound may be (1 point ) *
Question 23
HEPA filter efficiency is monitored with the (1 point ) *
Question 24
Which of the following is not used as a reactant gas in chemical ionization mass
spectrometer (1 point ) *
Question 25
Celutab having flowability (1 point ) *
Question 26
Loratadine is chemically (1 point ) *
Question 27
The water soluble analogue of Prazocin is (1 point ) *
Question 28
choose the correct statement (1 point ) *
Question 29
Which statement is false on organic nitrates? (1 point ) *
Question 30
one of the following is intermediate in synthesis of Atenolol (1 point ) *
Question 31
Determine the correctness or otherwise of the following Assertion [a] and the Reason [r].
Assertion The container closure system for storage or shipment of a bulk solid drug substance is
typically a drum with double LDPE (Low Density Polyethylene) liners.
Reason: Because LDPE is a particularly good moisture barrier (1 point ) *
Question 32
Statement not Correct regarding diuretc (When use for hypertensive patient)is (1 point ) *
Question 33
which of the following statement is incorrect regarding emulsion (1 point ) *
Question 34
which of the following surfactant used in many antacid preparations? (1 point ) *
Question 35
which of the following leukotriene agonist used to treat mild asthmatics (1 point ) *
Question 36
Starting material for the synthesis of Ranitidine is (1 point ) *
Question 37
Empirical Formula of Talc is (1 point ) *
Question 38
Hydroxyethylcellulose is:- I -Coating agent II-thickening agent III-suspending agent (1 point ) *
Question 39
Determine the correctness or otherwise of the following Assertion [a] and the Reason [r].
Assertion: The amount of suspending agent used depends on the volume of the suspension
Reason: The amount of suspending agent used depends on the amount of powder to be suspended (1 point ) *
Question 40
(3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one- is a (1 point ) *
Question 41
Moblie phase for Normal Phase HPLC is (1 point ) *
Question 42
Electron capture detector for gas chromatography is selective for (1 point ) *
Question 43
When separating proteins using gel filtration chromatography, the first proteins to be eluted will be (1 point ) *
Question 44
Elimination of drug in neonate is ………….. Than older children (1 point ) *
Question 45
Best approch for elimination of poison from body is /are (1 point ) *
Question 46
Which of the following synthetic steroids shows predominantly mineralocorticoid action? (1 point ) *
Question 47
Immunosupressive effect of glucocorticoids is caused by: (1 point ) *
Question 48
Antibiotics which is not bactericidal (1 point ) *
Question 49
Otoxicity cannot follow the administration of: (1 point ) *
Question 50
Which of the following drug is glycopeptides derivative? (1 point ) *
Question 51
In Cephalosporins, higher resistance to hydrolysis by beta -lactamase is shown when (1 point ) *
Question 52
The drug which belong to aromatase inhibitors? (1 point ) *
Question 53
First line therapy for chloroquine- resistant falciparum malaria (1 point ) *
Question 54
Antidote used for organophosphate insecticide (1 point ) *
Question 55
Which NSAIDs is a Prescription product (1 point ) *
Question 56
Presence of one of the following is the
most important cell‐wall properties of gram‐positive bacteria and actinomycetes (1 point ) *
Question 57
Mycobacterium leprae is cultured in (1 point ) *
Question 58
Most commone clinical consequence of C3 deficiency is (1 point ) *
Question 59
The pneumococcal polysaccharide vaccine should be administered to all except which group? (1 point ) *
Question 60
Which of the following is not a suspension? (1 point ) *
Question 61
You are asked to prepare six 1 g suppositories each containing 200 mg of Zinc Oxide BP (displacement value = 4.7). How much Hard Fat BP base would be contained in each suppository? (1 point ) *
Question 62
Which one of the following drugs exhibits nonlinear pharmacokinetics at normal
therapeutic doses? (1 point ) *
Question 63
For zero-order drug elimination, half-life t(1/2) is ____ at two places on the curve
and a constant ____ is lost per unit time. (1 point ) *
Question 64
According to ICH Guideline for stability study of drug substance -for Accelerated study what is the Minimum time period covered by data at submission (1 point ) *
Question 65
How many number of members nominated by central Govt. in PCI Constitution (1 point ) *
Question 66
Which of the following is not an parentral third generation cephalosporin (1 point ) *
Question 67
Doxorubicin-(A) is a Anti tumour antibiotic. (B) Its toxicity usually exhibited on G1 phase. (C) They generate quinone type free radicals (1 point ) *
Question 68
Ergot is the......................of the fungus Claviceps purpurea. (1 point ) *
Question 69
In India Drug controller general of india (DCGI) can issue an order to ban a drug on the recommendation of (1 point ) *
Question 70
pregnancy test kits are designed to detect which substance? (1 point ) *
Question 71
According to Drug & Cosmetic ACT- Schedule M , A minimum area required for basic installation of LVP manufacturing plant (1 point ) *
Question 72
Which vasodialtor is a Non Prescription product (1 point ) *
Question 73
Which of the following is not a advantage of suppositories over conventional dosage form (1 point ) *
Question 74
D65 is the internationally recognized standard (for photostability testing)for (1 point ) *
Question 75
Which one is right group of the correct combination.
A. Southern Blot Technique I. Use for identification & Isolation of RNA
B. Northern Blot Technique II. Use for identification & Isolation of DNA
C. Western Blot Technique III. Use for identification & Isolation of Protein (1 point ) *
Question 76
Dwell time is (1 point ) *
Question 77
Upto the production of desirable production in the fermentor is called (1 point ) *
Question 78
Non-lactose fermenting colonies seen on Mac Conkey’s medium are (1 point ) *
Question 79
Choose the correct pair- Instrument : Sterilization technique (1 point ) *
Question 80
Choose the correct pair for substances which are assayed by organisms (1 point ) *
Question 81
The diagnosis of tuberculosis is carried out by
1. Emulator 2. Antiformin method
3. Petroff’s method (1 point ) *
Question 82
The suitable assay method for antibiotics is (1 point ) *
Question 83
C. diphtheriae consists of (1 point ) *
Question 84
Bacilli Calmette Guerin (BCG) contains the avirulent strains of (1 point ) *
Question 85
Neurological complications is common with following
rabies vaccines (1 point ) *
Question 86
Aspergilius fumigates can produce (1 point ) *
Question 87
Which of the following vaccine can be administered if disease indicated to pregnant woman (1 point ) *
Question 88
All of the following drug are assayed by Complexiometric Titration EXCEPT (1 point ) *
Question 89
Which of the following method is used to assay of Salbutamol (1 point ) *
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