Clinical Neuropathology QUIZ #2
Published in Clinical Neuropathology vol 39, issue 5 (September/October 2020). Based on papers and editorial of Clinical Neuropathology of the previous issue (issue 4, July/August 2020) which you can access here:
1. All of the following are typical histologic features of measles inclusion body encephalitis EXCEPT
a - A prominent lymphocytic infiltrate
b - Multinucleated cells
c - Microglial nodules
d - Eosinophilic intranuclear inclusions
e - Gliosis
2. Which of the following statements regarding measles encephalitis is TRUE?
a - The incidence in developed countries has been steadily decreasing
b - It is caused by a double-stranded RNA-virus
c - Measles encephalitis may develop weeks to years after the primary infection
d - Subacute sclerosing panencephalitis (SSPE) is typically associated with a poor immunological response
e - Measles inclusion body encephalitis is more frequent in immunocompetent than immunocompromised individuals
3. Which of the following statements is TRUE concerning Pick's Disease?
a - the clinical presentation includes behavioral anomalies and aphasia
b - Gallyas does not stain Pick bodies because it is sensitive to the 4R tau-isoform
c - Familial cases of Pick's Disease due to mutations in exons 9-13 in the tau-gene have been reported
d - in an experimental setting, brain homogenates from human tauopathies can induce tau-filaments when injected into mouse brains
e - All of the above
4. Which of the following statements regarding neurofibromatosis type 2 is true?
a - most of the cases are familial
b - It is caused by a mutation of the NF2 tumor suppressor gene located on chromosome 9
c - Neurofibromatosis type 2 is commonly associated with perineuriomas
d - NF2 is inherited in an autosomal-dominant fashion
e - none of the above
5. Which of the following statements regarding perineuriomas is correct?
a - They may be subdivided into soft tissue neuromas, intraneural perineuriomas and sclerosing perineuriomas
b - Intraneural perineuriomas are exclusively due to TRAF7 gene mutations
c - By immunohistochemistry, these tumors are typically negative for INI1.
d - Perineuriomas often have alterations in both TRAF7 and NF2 genes.
e - all of the above.
6. A mutation in which of the following genes is reported to be associated with a progression from anaplastic ependymoma to ependymosarcoma in the case report by Pujadas et al?
a - RB1
b - TSC1
c - TSC2
d - TP53
e - BRAF
7. Which of the following categories of anaplastic gliomas is not defined by the WHO 2016 classification of Tumours of the Nervous System?
a - Anaplastic astrocytoma, IDH mutant
b - Anaplastic oligodendroglioma, IDH mutant and 1p/19q co-deleted
c - Anaplastic astrocytoma, IDH wildtype
d - Anaplastic oligoastrocytoma, NOS
e - Anaplastic oligodendroglioma, IDH wildtype and 1p/19q intact
8. Which of the following are known prognostic factors in anaplastic gliomas?
a - patient age
b - tumor location
c - IDH mutation status
d - extent of resection
e - all of the above
9. Which of the following is a common histological/immunohistochemical feature of chondroma?
a - low proliferation index
b - presence of fibrous cartilage
c - spindle cell components
d - admixed connective tissue
e - positivity for EMA
10. Chondromas of the meninges …
a - perhaps develop from multipotential mesenchymal cells of the meninges
b - are rare neoplasms
c - may mimic meningioma on imaging studies
d - thus far have not been associated with IDH1/2 or HMGA2 mutations
e - all of the above
This form was created inside of Euro-CNS.