Today you are meeting a new patient. Mrs. Friedman is a 54 year old female who is coming in for a “meet and greet” appointment. During the interview you learn the following: She is recently widowed, her and her late husband had 2 children who are now very successful in their fields. She was born in Canada and is of Ashkenazi Jew descent. She has never had any significant surgeries, and her past medical history is significant for hypertension which she is managing with lifestyle and diet. She takes no medications. She worked as a professor at the local college, teaching english. You finish up chatting and feel that you have made a connection with the patient. On her way out the door she states, “Oh yeah, I’m not sure if it’s important or not but my sister has this thing they found in her genes that increases her risk for some cancers, breast and ovarian I think”. What germline mutation is she most likely talking about?