Join - In Silico Drug Repurposing
Which step of the project are you interested in?
A. Crowdsource to build a systems biology model for the virus, and for drug target identification
B. Virus target on host receptor (ACE2) modeling
C. Host factors that can protect from the virus
If you selected step A. (Crowdsource), which of these area(s) of the project are you interested in?
(i) Search literature, and characterize each of the proteins of SARS-CoV-2 (COVID_19), as well as their homologues
(ii) Place all of these proteins in their functional context; namely, specific to the host target and its self-assembly
(iii) Identify the most essential proteins as the specific targets of interest for therapeutic development (e.g., Spike Trimer, TMPRSS2, etc.)
(iv) Build InSilco 3D structures, based on homology modeling
(v) Undertake molecular docking for each target
(vii) Examine at the interacting surface of the spike trimmer protein and search for potential inhibitors
If you selected step B. (Virus target), which of these area(s) of the project are you interested in?
(i) Identify all of the host receptor (ACE2) polymorphisms in the various populations profiled in the global each population human genome databases. Try to correlate these with the potential affinity variation with spike protein
(ii) Search (in silico) for inhibitors that can block this interaction
If you selected step C. (Host factors), which of these area(s) of the project are you interested in?
(i) Various host miRNA and other variabilities that can target the virus RNA and block processing and/or degrade the viral RNA
(ii) Determine what targets can reduce a cytokine storm
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