These games were the most popular suggestions from the YouTube comments. If you're unfamiliar with the games, you'll see below their blurbs:

Ultima VII: The Black Gate (1992) [replay]: In the seventh installment of the Ultima series you — the Avatar — must go back to Britannia and investigate a series of strange events. Two hundred years have passed since your last visit and much has changed since then. An unknown being who calls himself the Guardian has appeared and is forcing everyone to bow to his whims. In addition magic doesn't work as it should, it seems that all of the mages have gone insane, and quiet towns are being terrorized with ritualized murders. It is unclear what is happening, but initial signs point to some kind of organization called the Fellowship. It is up to you to unravel the mystery and find out what is really going on in Britannia. This would be a replay; the original LP started in 2009, with 360p video quality.
Quest for Glory III: Wages of War (1992): After saving Shapeir and being adopted as the Prince of Shapeir, a title which he is subsequently identified by, the Hero follows the paladin Rakeesh back to his Liontaur homeland of Tarna, a land inspired by ancient Egyptian and African myth.
Legend of Grimrock 2 (2014): Legend of Grimrock 2 is a dungeon crawling role playing game with a modern execution but an oldschool heart. A group of four prisoners have shipwrecked on the secluded Isle of Nex. The island is filled with ancient crumbled ruins, mysterious shrines and a vast underground network of dungeons.
Lands of Lore: Guardians of Destiny (1997) [evil playthrough]: In Lands of Lore: Guardians of Destiny (also known as Lands of Lore 2) you enter a world of intense beauty and mortal danger where your slightest move can trigger cataclysmic events, miraculous escapes, or lethal battles. See magical cities rise out of great oceans. This would be a replay, with original series starting in 2008. But it would be a very different one - an evil playthrough, which changes the game considerably.
Indiana Jones and the Fate of Atlantis (1992): The Man With The Hat Is Back In His Greatest Adventure Yet! 1939 - The eve of World War II. Nazi agents are about to get their hands on a weapon more dangerous than the atom bomb. Only Indy can stop them before they unleash the deadly secret that sank Atlantis.
Vampire: The Masquerade – Bloodlines (2004): Vampire: The Masquerade – Bloodlines delivers a new type of RPG experience-one that blends all the core elements of a traditional RPG with the graphical richness, immediacy and brutal combat of a first-person action game. The game plunges players into the dark and gritty vampire underworld of modern-day L.A. as a creature of the night.
Shining Force 2 (1994): As a student of Astral the wizard, you and your friends study all the usual subjects: reading, writing, and sword fighting. As your time at school draws to an end, dark events are taking place on the island of Grans. The two Jewels which seal the Door to Darkness have been stolen, allowing a creature of awesome power to be unleashed.
Cave Story+ (2004/2011): Run, jump, shoot, fly and explore your way through a massive action-adventure reminiscent of classic 8- and 16-bit games.
Beyond a Steel Sky (2020): From multi-award winning Revolution comes ‘Beyond a Steel Sky’, a groundbreaking 3D adventure thriller, set in an AI-driven future. Subvert the world, hack the systems and solve dark conspiracies to uncover the devastating truth.