FUNDAMENTALS OF MASS SPECTROMETRY AND HYPHENATED MS TECHNIQUES APPLIED TO ANALYSIS OF DRUGS OF ABUSE, EXPLOSIVES, AND BIOTERRORISM, DR. GUIDO VERBECK, 8-12:00pm, This 4-hour course will include the fundamentals of Mass Spectrometry as it is applied to the analysis of illicit chemistries. This focus will give a good overview of instrument resolution, sensitivity, and performance issues. Ion source options will be discussed within the confines of these forensic applications. Special attention will be paid to the trace analysis of illicit drugs, arson and explosive, paint and Chem/Bio weapons. Hybrid techniques (LC-MS, GC-MS, and CE-MS) and Tandem instrumentation (CID, Triple-Quad, and MSn) will be covered. Alongside the common issues with hyphenated techniques, direct injection (DART, DESU, Paperspray, DAPNe) will also be introduced. Two specific areas of interest will be focused on: The introduction to terrorism, and the future of chemical weapon analysis, and rapid synthesis of new drugs of abuse to stay ahead of the clandestine labs. These are fast emerging areas that need attention and training. Due to the increasing demand for field-portable instrumentation, the current state and limitations of this growing area will be another special topic.