WSI quality should be analysed at different levels, such as focus, color, contrast, resolution, noise and distorted tissue artifacts. Another aspect to be analysed is the effect of the display and monitors. All these issues are taking into account in this survey open to pathologists. The survey will be done at 4 stages. The 1st stage is already published and contains 50 images of breast Her2. The 2nd stage will be Ki67, the 3rd stage will consider other biomarkers such as ER and PR and finally the 4th stage will be with HEO.