Clinical Neuropathology QUIZ #24

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Published in Clinical Neuropathology Vol 42 nr. 3, May/June 2024. Based on papers and editorial of Clinical Neuropathology of the same issue: https://www.dustri.com/nc/journals-in-english/mag/clinical-neuropathology/vol/volume-43-2024/issue/mayjune-17.html

1. Which of the following genes may show a molecular alteration associated with peripheral eosinophilia?

1 point

a - PDGFRA

b - PDGFRB

c - FGFR1

d - JAK2

e - All of the above

2. Which of the following histological features is NOT a typical change in idiopathic hypereosinophilic syndrome?

1 point

a - Eosinophilic inflammation

b - Vascular thrombi

c - Infarcts

d - Parasitic infestation

e - None of the above

3. Which of the following histological features may be observed in corticobasal degeneration?

1 point

a - Astrocytic plaques

b - Neuropil threads

c - Coiled bodies

d - Neuronal loss

e - All of the above

4. Which of the following molecular alterations has NOT been described in polymorphous low-grade neuroepithelial tumor of the young (PLNTY)? *

1 point

a - FGFR2-INA fusion

b - FGFR-TACC3 fusion

c - IDH1(R132H) mutation

d - BRAF(V600E) mutation

e - FGFR2-KIA1598 fusion

5. Which of the following tumor types may be considered in the differential diagnosis of PLNTY? *

1 point

a - Ganglioglioma

b - Dysembryoblastic neuroepithelial tumor

c - Oligodendroglioma

d - Diffuse low-grade glioma, MAPK pathway altered

e - All of the above

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