This study aims to compare, in a real-world setting, the cumulative incidence of severe infections (G3-G5) in CLL patients treated with venetoclax-based regimens or second-generation BTKi within the centers of ERIC.
The study will consist of two cohorts with 24-month follow-up.
Cohort A – treatment-naïve CLL patients treated in 1st line with venetoclax-based regimens or second-generation BTKi.
Cohort B – relapsed/refractory CLL patients treated in 2nd line with venetoclax-based regimens or second-generation BTKi, without prior chemoimmunotherapy (CIT)