gamma_ADH_survey

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gamma_ADH_survey

Understanding the consequences of a mutation in human Gamma-2 Alcohol Dehydrogenase.

1. How many protein chains are in human Gamma-2 Alcohol Dehydrogenase? *

2. Which region of one protein chain interacts with other protein chains? *

amino acids 1-98 (the amino end)

amino acids 115-191

amino acids 200-255

amino acids 258-319

amino acids 320-374 (the carboxyl end)

3. Which amino acids are bound to the zinc ion at the active site? *

Select all the amino acids that are bound to the active site zinc.

Cys 46

Cys 240

Cys 174

His 67

Cys 281

Cys 282

Required

4. The G78stop mutation in Human Gamma-2 Alcohol Dehydrognease has been associated with a rare form of Parkinsons' disease. *

Select all the possible outcomes that are likely to result from this mutation.

All the amino acids that bind to zinc will be gone.

The protein will have increased kinase activity.

Some of the amino acids that bind to the cofactor will be gone.

The protein will phosphorylate new substrates.

The protein subunits will not interact.

Required

5. Did this activity help you understand why the G78stop mutation has serious consequences? *

Pease explain why you thought this activity was or was not helpful. If you have any other comments, please add them.

6. What is your occupation?

Please select the most appropriate answer

High school student

College or University student

High school teacher

College or University instructor

Graduate student

Other:

Clear selection

7. If you are a college or graduate student, what is your major?

If this is an assignment from Dr. Porter, please enter your name.

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