Clinical Neuropathology QUIZ #3
Published in Clinical Neuropathology 39/5 (September/October 2020). Based on papers and editorial of the same issue. For your reference, here is the link to the table of content of issue 5:
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1. Within the Qualitative Assurance Initiative Pathology (QuIP) programme, which of the following tests has not yet been included in a round robin trial?
a - IDH1-R132H Immunohistochemistry
b - TERT promoter mutation
c - MGMT promoter methylation
d - IDH1/2 mutation status
e - none of the above
2. Which of the following statements regarding CNS lymphoma is correct?
a - They are usually located infratentorially
b - they occur most often in children and young adults
c - incidence rates have increased within the past decade
d - some cases are associated with an underlying autoimmune disorder
e - follicular lymphoma is fairly common in the CNS
3. Which of the following is the most common type of lymphoma on the CNS?
a - diffuse large B-Cell lymphoma
b - high grade Lymphoma
c - mantle cell lymphoma
d - primary NK/T-cell lymphoma
e - post-transplant lymphoproliferative disorder
4. Which of the following characteristics distinguishes pulmonary barotrauma from decompression sickness?
a - the localization of gas collections on radiographs
b - an injury to the pleural surfaces
c - signs of decomposition on external examination of the body
d - the diving history and equipment used
e - The localization/distribution of optically empty spaces on microscopic examination of the brain
5. In the case of Fahr's Disease co-occurring with dementia with Lewy Bodies, a mutation in which of the following genes was found?
a - SCL20A2
b - PDGFB
c - APP
d - FUS
e - GRN
6. Which of the following entities has to be considered in the differential diagnosis of epithelial sheath neuroma?
a - traumatic neuroma
b - squamous cell carcinoma
c -malignant neural neoplasm with heterologous elements
d - re-excision perineurial invasion
e - all of the above
7. For which of the following tumors copy number variation and somatic mutation burden have been shown to be of prognostic significance?
a - astrocytomas WHO Grade II/III
b - medulloblastomas
c - ependymomas
d - CNS lymphomas
e - metastases
8. All of the following statements regarding copy number variation and somatic mutation burden in oligodendroglioma as described by Richardson et al are correct except:
a - There is a significant correlation of total CNV with clinical outcomes
b - a cut-off for the distinction of good outcome versus poor outcome could be established
c - In an independent cohort of oligodendrogliomas, results were reproducible
d - somatic mutation burden is higher in cases with poor outcome
e - somatic mutation burden may be a useful prognostic marker in oligodendroglioma
9. Which of the following statements regarding aging related tau astrogliopathy is not correct
a - it is a 3R-tauopathy
b - it occurs primarily in the elderly
c - ist incidence increases with age
d - there is no known association with clinical dementia
e - it is morphologically characterized characterized by thorny-shaped astrocytes and granular fuzzy astrocytes
10. All of the following statements regarding inclusion body myositis are correct except
a - it belongs to the category of inflammatory myopathies
b - A PIB pet scan may serve to demonstrate the location of the disease process in vivo
c - The condition is associated with deposits af amyloid beta in muscle
d - Histologically, rimmed vacuoles are seen in affected muscle
e - most cases of inclusion body myositis are hereditary
This form was created inside of Euro-CNS.