CH2: Choose only one answer

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For topic Hormones and Tumor Markers
By Dr Mohammad Moharram

1- A 45 year old woman complains of fatigue , heat intolerance and hair loss. Total & free T4 are abnormally low. If the TSH showed marked elevation, this would be consistent with: *

1 point

A) Graves disease.

B) An adenoma of the thyroid.

C) Thyrotoxicosis

D) Primary hypothyroidism

2- A 2 year old child with a decrease serum T4 is described as being somewhat dwarf, stocky, overweight, and having coarse features. Of the following, the most informative additional laboratory test would be the serum: *

1 point

A) Thyroxine binding globulin (TBG)

B) Thyroid stimulating hormone (TSH)

C) Triidothyronine (T3)

D) Cholesterol

3- Assays for free T4 measure hormone not bound to thyroxine-binding prealbumin, thyroxine-binding globulin and : *

1 point

A) Thyrotopin-releasing hormone

B) Albumin

C) Free T3

D) Thyroid-stimulating hormone

4- During pregnancy , the form of estrogen measured in urine is mostly: *

1 point

A) Estradiol

B) Estriol

C) Estrone

D) Pregnanediol

5- In amniotic fluid , the procedure used to detect hemolytic disease of the newborn is: *

1 point

A) measurement of absorbance at 450nm

B) creatinine

C) lecithin/ sphingomyelin ratio

D) estriol

6- During a normal pregnancy , quantitative human chorionic gonadotropin (HCG) level peak how many weeks after the last menstrual period? *

1 point

A) 2-4

B) 8-10

C) 14-16

D) 18-20

7- What is the commonest substrate used in the biosynthesis of adrenal steroids, including androgens and estrogens? *

1 point

A) Cortisol

B) Catecholamines

C) Progesterone

D) Cholesterol

8- In addition to carcinoma of the prostate , elevated prostate specific antigen (PSA) can occur due to: *

1 point

A) aspirin therapy

B) exogenous steroid use

C) benign prostatic hyperplasia

D) stain therapy (cholesterol lowering drug)

9- Detection of which of the following substances is most useful to monitor the course of a patient with testicular cancer? *

1 point

A) Alpha-fetoprotein

B) Carcinoembryonic antigen

C) Prolactin

D) Testosterone

10- Clinical assays for tumor markers are most important for: *

1 point

A) screening for the presence of cancer.

B) monitoring the course of a known cancer.

C) confirming the absence of disease.

D) identifying patient at risk for cancer.

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