28 May 2024 | Tuesday | 12:00 CET | Zoom
Prof. Dr. James Di Santo
Institute Pasteur, Department of Immunology, INSERM unit U1223
Title: Innate lymphoid cells: development, differentiation, dynamics
Innate lymphoid cells (ILCs) are a family of specialized immune cells
that differentiate from hematopoietic precursors into canonical groups (ILC1,
ILC2, ILC3) that can rapidly provide critical soluble cytokines in the context
of infection and inflammation. ILCs have the potential to sense environmental
changes within tissues which can imprint changes in their effector functions: this
can result in durable reinforced capacities (‘training’ and ‘fitness’) or new
functionalities (‘plasticity’). The mechanistic underpinning of these
environmentally induced changes in ILC function are unclear but the re-wiring
of metabolic pathways is likely to be involved. How ILCs physically behave as
long-lived tissue-resident cells is likewise poorly understood. Here I will
describe recent and ongoing studies to understand the impact of intestinal ILC
heterogeneity and cellular dynamics for mucosal barrier function in health and
disease.
Bio: James Di Santo received
MD and PhD degrees from Cornell Medical College and the Sloan Kettering
Institute in New York and completed postdoctoral training with Pr Alain Fischer
(Necker Hospital, Paris, France) and Pr Klaus Rajewsky (Institute for Genetics,
Cologne, Germany). In 1999, he moved to the Immunology Department of Institut
Pasteur in Paris where he directs the Innate Immunity Unit and the Inserm Unit
1223 (Pathophysiology of the Immune System). Pr. Di Santo’s research involves
study of cytokines, transcription factors and signaling pathways in the
development and function of both adaptive (T and B cell) and innate (ILC, NK
cells) lymphocytes in mice and man with applications for treatment of human
infectious diseases.
Organizer: Sebastian TheobaldContact: youngimmunologists@dgfi.org
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