Chemotherapy related questions

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1. Which of the following statements is correct? *

10 points

Diarrhoea caused by irinotecan within first 24 hours after chemotherapy is due to SN 38 induced bowel toxicity

Palmar-plantar erythrodysaesthesia caused by liposomal doxorubicin is made worse by exposure to cold

Laryngopharyngeal dysesthesia caused by oxaliplatin is characterized by drop in oxygen saturation

In colonic carcinoma with potentially rescectable liver metastasis, preoperative chemotherapy with FOLFOX can cause blue liver due to oxaliplatin induced sinusoidal dilatation

2..Which of the following drugs will have increased toxicity when combined with allopurinol? *

10 points

Vincristine

5-flurouracil

Azacitidine

Correct answer 3

6-Mercaptopurine ( 6-MP)

3. Which of the following statements about hormonal treatments is correct? *

10 points

Tamoxifen is less likely than an aromatase inhibitor to cause thromboembolic events

Aromatase inhibitors should not be given to premenopausal women after ovarian function suppression

Tamoxifen is less likely than aromatase inhibitors to cause arthralgia

Aromatase inhibitors are less likely than tamoxifen to cause endometrial hyperplasia

4. Which of these anticancer agents act by depolymerization of microtubules

10 points

Cladrabine

Vinorelbine

Etoposide

Irrinotican

Clear selection

5. A man with metastatic NSGCT is being treated with BEP chemotherapy. When he attends his second cycle of chemotherapy, he complaints of mild exertional dyspnea. What is the most appropriate management?

10 points

Delay chemotherapy for one week and allow patient to improve

Treat with oxygen, antibiotics and high dose intravenous steroids and continue with the third cycle of BEP without delay

Stop BEP and change to TIP for the remaining cycles

Investigate with CXR, HRCT chest and pulmonary function tests, proceeding with EP for total of four cycles if bleomycin toxicity is suspected

Clear selection

6. Which one of the following cytotoxic drugs is a vesicant when extravasated?

10 points

Carboplatin

Bleomycin

Methotrexate

Paclitaxel

Other:

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7. Which of the following statements about erlotinib is correct?

10 points

It is a monoclonal antibody directed against EGFR

The recommended dose is 200mg daily

Patients who develops the acniform rash typically have a worse prognosis than who do not

The rash caused by erlotinib responds to topical clindamycin

Clear selection

8. Which of the following statements regarding carboplatin and paclitaxel is correct?

10 points

Carboplatin and paclitaxel have different routes of excretion so that the order in which they are given does not matter

Paclitaxel is given after carboplatin to reduce the risk of myelosuppression

Paclitaxel is given before carboplatin , otherwise there is a 20% reduction in paclitaxel clearance

Paclitaxel and carboplatin is given simultaneously to reduce the treatment time for the patient

Clear selection

9. A 55-year-old man is having renal cancer with multiple lung metastases. His Karnofsky performance statatus is 70. His Haemoglobin level is 10.5 g/dl and his serum corrected calcium level is 2.9 mmol/ l. What management would you recommend?

10 points

Tyrosine kinase inhibitor Pazopanib 800mg daily

Immune therapy with Nivolumab and ipilimumab

Symptomatic management with best supportive care

Interferon ∝

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10. A patient with cervical cancer who is on radical chemoradiotherapy, presented at the tenth day following the last dose of cisplatin with paraesthesiae, muscle cramps tremor, and hyperreflexia with a calcium level of 1.89 mmol/l. Her symptoms persisted in spite of the prompt correction of calcium. What is the most likely biochemical cause for her symptoms?

10 points

Hypokalemia

Hyponatraemia

Hypomagnesaemia

Hyperphosphataemia

Other:

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