MGMT analysis
We hope you as a neuro-pathologist are able to spend a couple of minutes to answer the survey and share your opinion and experience.

MGMT promotor methylation status is included in the WHO 2016 classification of gliomas to facilitate clinical decision making. Internationally different methods and different cut-off levels are used to define a tumor as methylated or unmethylated, thereby selecting partly different patient populations.
In this survey we wish to find out which different methods are regularly used for clinic and the reason for selecting the specific method.
The results are planned to be reported at the EANO meeting in October 2018 in Stockholm.

Thank you for your contribution!

Dr Annika Malmström, Prof Bjarne Winther Kristensen, Prof Peter Söderkvist and Prof Roger Henriksson representing the Scandinavian Neuro-Oncology Society

1. Is MGMT methylation analyzed for treatment decisions in the clinic
2. If MGMT is analyzed for another settings than above (question 1), please note below which patients are selected
Your answer
3. What method for determining MGMT methylation status for the clinic is used at your department
4. If another method or laboratory is used for determining MGMT methylation status (question 3) , please note below which method or lab is selected
Your answer
5. Why do you use the method specified above (question 3 and 4)
6. If another or additional reason, please note below
Your answer
7. If you determine CpG sites by sequencing, please answer the following questions, otherwise move to question number 10. How many CpG sites do you examine?
8. How are the analyzed CpG sites selected?
9. How is the CpG island methylation rate calculated?
10. Which cut-off level for methylated versus non-methylated tumor do you use?
11. If another method for defining the cut-off level is used, please note the method below
Your answer
12. What cut-off level do you use for defining methylated versus unmethylated tumor
13. If you use another cut-off level for methylated versus unmethylated tumor, please note cut-off level below
Your answer
14. Who pays for the testing
15. If testing is payed by other means, please note below
Your answer
16. How often is MGMT testing performed, in average
17. Please comment on the frequency of MGMT testing, if none of the above apply
Your answer
18. Please comment on the number of samples you analyze in a run
Your answer
19. Do you think it would be an advantage to have international consensus on one method for MGMT testing?
20. Do you think it would be an advantage to have international consensus on one cut-off level for MGMT testing?
21. Do you have any additional comment regarding the above questions?
Your answer
22. Which method do you believe would be the most suitable for an international consensus for MGMT testing in the clinic?
23. If you suggest another method for international consensus for MGMT analysis, please note the method below
Your answer
24. Why would you suggest the method above for international consensus for MGMT testing in the clinic?
25. Are there any additional reasons to chose the method you prefer
Your answer
26. Do you have any further comments
Your answer
27. In which country are you working
Your answer
Contact information (voluntary information)
Your answer
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