Workshop "3D models applications in toxicology: courses and handling session"
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This WC13 satellite workshop, organized by MatTek, INMETRO, and BCRJ, will explore practical and regulatory aspects of 3D models in toxicology. The morning session (150 participants) features presentations on human organotypic 3D tissues, their integration into New Approach Methodologies (NAMs), and regulatory perspectives, with a focus on Brazil’s initiatives. The afternoon is a hands-on training (10–15 participants) on 3D tissue models, reserved for select regulatory and research representatives. The event is free with pre-registration and aims to foster expertise and collaboration in alternative toxicological methods.
AGENDA

Morning session: 
(150 participants max.)

INMETRO, Av. Nossa Senhora das Graças, no. 50, Prédio 06 (auditório). Xerém, Duque de Caxias, RJ


8:00 – 8:30 - Registration
8:30 - 9:00  -  Welcome 
  • Márcio André de Oliveira Brito, Inmetro President
  • Paola Cappelleti, Supervisora BCRJ 
  • Alex Armento, CEO of MatTek 
9:00 - 9:15 –  Brazilian Network of Alternative Methods (RENAMA)
  • Thiago Mello de Moraes, General Coordinator of Health, Biotechnological and Agrarian Sciences, Ministry of Science, Technology and Innovation (MCTI)
9:15 - 9:45 - Human organotypic 3D tissues: Mattek holistic approach 
                        - Emily Reis, Principal Scientist - MatTek
09:45 - 10:00 – Q&A

Coffee break

10:20 - 10:50 – 3D models in NAMs strategy, regulatory acceptance and perspectives 
                           - Christian Pellevoisin, Scientific Director - MatTek
10:50 - 11:05 – Q&A

11:05 – 11:45 - NAMs implementation and development in Brazil (Panel Discussion)                        
  • Thiago Mello de Moraes, General Coordinator of Health, Biotechnological and Agrarian Sciences (CGSB), Ministry of Science, Technology and Innovation (MCTI)
  • Luisa Macedo Braga, Coordinator of the National Council for the Control of Animal Experimentation (CONCEA), Ministry of Science, Technology and Innovation (MCTI)
  • Octavio Presgrave, Coordinator of the Brazilian Center for the Validation of Alternative Methods, Oswaldo Cruz Foundation (Fiocruz)
  • Elkiane Macedo Rama, Advisor to the General Management of Cosmetics and Sanitary Products (GGCOS), National Health Surveillance Agency (ANVISA)
  • Christian Pellevoisin, Scientific director, MatTek
11:45 – 12:00 – Closing session 

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12:30 - 13:30 – Lunch
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Afternoon session: 13:30 - 16:20  (Registrations closed)
(10-15 participants)

13:30- 14:00  – Introduction BCRJ  (Registrations closed)
                          - Ana Carolina Batista, Supervisora do Bianbanco
                          - Paola Cappelletti, Supervisora do Laboratorio de Toxicologia. 

14:00- 16:30  – Hands-on training session (Registrations closed)
                         
                           - Emily Reis, Principal Scientist - MatTek

                     - Presentation of the EpiOcular, EpiDerm and EpiDerm FT models 
                     - Hands-on session: based on OECD TG492 with EpiOcular model   


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