An 8-year old girl with a history of asthma presents to the
emergency room with increased shortness of breath and cough. Her mother
reports that her symptoms began overnight and worsened throughout the
morning, despite implementation of her single inhaler maintenance and
reliever therapy (SMART) asthma action plan.
Her mother reports that her daughter takes her maintenance
budesonide/formoterol with spacer as prescribed and is up to date on her
vaccinations, including annual influenza vaccination and COVID-19 booster.
She has no known sick contacts. Her mother notes that her home environment
has been discussed with her pediatrician and there are no carpets, pets or
visible mold, her daughter sleeps on hypoallergenic bedding, there are no
smokers in the household. On further questioning, you learn that the family
lives next to a major roadway that is a truck route and the daughter’s asthma
control has worsening significantly since the family moved in a year ago.
On exam, she is afebrile
but tachycardic and tachypneic with diffuse inspiratory and expiratory
wheezing and notable accessory muscle use. You begin proper medical therapy.
Which of the following is
the most likely contributing cause of the patient’s asthma exacerbation?