2019-Registration: Bioengineering and Critical Thinking
COURSE DESCRIPTION

Learning objectives
A student who has met the objectives of the course will be able to:

1. Describe emerging themes in cell factory engineering and synthetic biology
2. Have a foundation to critically analyze data from primary literature in cell factory engineering and synthetic biology
3. Describe common methods used in development of cell factory engineering and synthetic biology
4. Describe common methods used in biobased production of chemicals, enzymes and therapeutic proteins
5. Explain how experiments in the primary literature in cell factory engineering and synthetic biology research were performed
6. Discuss the positive and negative controls that are or should have been used in the primary literature investigating cell factory engineering and synthetic biology
7. Evaluate whether or not a particular series of experiments warrants the conclusion made by the authors of a study
8. Summarize efficiently the key findings of a scientific paper

Content
Biotechnology is currently being revolutionized by rapid and extraordinary technological advances in molecular and synthetic biology that have led to unprecedented improvements in bio-based production. Translating this knowledge into new commercial processes demands a deep understanding of the synthetic and systems biology of living cells, and approaches for engineering cell factories.
Bio-manufacturing is a rapidly developing field, as demand is growing to replace oil-based industry with biosustainable methods for production of chemicals and proteins essential for therapeutics and other purposes. Optimization of microbial cell factories through metabolic engineering is of central importance for efficient biological production of chemicals. Cell factory design is informed by integrating metabolic research, synthetic biology, ‘omics and modeling, while high-throughput technologies support efficient production with high yield. At the same time synthetic biology is influencing the way we design experiments in basic research.
The course brings together a group of experienced researchers to provide training on how to analyze data and think critically about state-of-the-art cellular, molecular, and computational techniques and approaches for optimization of cell factory engineering and biosustainability. Specifically, the content of the course will focus on discussing primary literature from current topics in bacterial, yeast and mammalian cell factory engineering; synthetic biology; and biosustainable production of beneficial compounds (e.g. antibiotics; therapeutic proteins).

Participants
Ph. D. –level students with a B.Sc. and/or M.Sc. degree in any biological science or chemistry are eligible to apply. The course is limited to a maximum of 25 participants.

Language
English

Form
Students will participate in group literature discussion sessions led by leading researchers in several fields of bioengineering research, from the Novo Nordisk Foundation Center for Biosustainability at the Technical University of Denmark. Literature discussion sessions will take place weekly on Fridays for four weeks. A week before each session, a problem set of relevant scientific papers and questions based on their content will be provided. Students must then read the papers critically and submit a written report comprising the answers to the set questions before the discussion session. The discussion will then be based on the problem set. Evaluation (pass/fail) will take into account participation in discussion sessions and written work.

Course director
Morten Nørholm, Senior Researcher, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark

Course organiser
Moreno Papetti, Programme Coordinator, Copenhagen Bioscience PhD programme, University of Copenhagen and Technical University of Denmark
moreno.papetti@cpr.ku.dk

Teachers
Group Leaders from the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark: http://www.biosustain.dtu.dk/

Dates
Three-hour discussion sessions on the following dates. Extensive reading of current literature (approx. 6-8 hours per session) and preparation of a written report are required in advance of each.
Friday 15 February, 2019
Friday 22 February, 2019
Friday 1 March, 2019
Friday 8 March, 2019
(2.5 ECTS)

Course location
Technical University of Denmark, 2800 Kongens Lyngby

Registration
Please apply before 12 January, 2019. Use this form to provide your name, email address, the university and PhD program where you are currently enrolled, and a 150 word (max.) statement of your motivation for applying for this course. You will be notified about your registration by email soon after the deadline. Contact moreno.papetti@cpr.ku.dk with any questions.

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