Pharma 6

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Pharma 6

لجنة الطب والجراحة

1. All the following are true except?

1 point

‏a. Benztropine, trihexyphenidyl, procyclidine and biperiden are antimuscarinic agents

‏b. Amantadine has several effects including Inhibiting N-methyl-D-aspartate type of ‏glutamate receptors

‏c. Rotigotine has duration of action longer than that of levodopa and therefore less effective

‏in patients exhibiting fluctuations in their response to levodopa هاي تكملة الخيار سي

‏e. Stalevo is an excellent combination of drugs for the management of Parkinson disease

2. All the following are true about Levodopa except?

1 point

‏a. Levodopa is a metabolic precursor of dopamine

‏b. Levodopa causes motor control fluctuations

‏c. Levodopa crosses the blood-brain barrier

‏d. It is carboxylated to dopamine in the periphery

‏e. It causes nausea, vomiting, cardiac arrhythmias, and hypotensio

3. One of the following is catechol O methyltrabsferase inhibitor?

1 point

‏a.Entacapone

‏b.Seligiline

‏c.Bromocriptine

‏d.Rotigotine

‏e.Apomorphine

4. Which of the following is not used for Parkinson?

1 point

‏a. Levodopa

‏b. Dopamine agonists

‏c. Dopamine antagonists

‏d. rasagiline

5. All the following are true except? Select one:

1 point

‏a. Carbidopa increases the availability of levodopa to the CNS

‏b. Concomitant administration of levodopa and monoamine reductase (MAO) inhibitors

‏c. Selegiline decreases metabolism of dopamine and increases dopamine levels in brain

‏d. Catechol-O-methyltransferase metabolizes levodopa to 3-O-methyldopa

‏e. Rotigotine activates the dopamine receptors to in patients with advanced Parkinson’s disease complicated by motor fluctuations and dyskinesias

6. All the following are true except? Select one:

1 point

‏a. Haloperidol and pramipexole antagonize the dopamine receptors and causes secondary parkinsonism

‏b. Levodopa is a metabolic precursor of dopamine restoring dopaminergic system by enhancing synthesis of dopamine

‏c. levodopa is actively transported into CNS and is converted to dopamine in brain

‏d. Carbidopa diminishes metabolism of levodopa in gastrointestinal tract and peripheral tissues; thus, it increases availability of levodopa to CNS

‏e. Levodopa has short half-life causing fluctuations in plasma concentration and may produce — fluctuations in motor response

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