Quiz 4.1.2

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Quiz 4.1.2

Macaulay et al zebrafish haematopoeisis single cell paper - dimensionality reduction

How does the number of components in *PCA* influence the t-SNE and MDS representations? Why? *

How does the number of components in *ICA* influence the t-SNE and MDS representations? Why? *

What matrix decomposition and manifold learning configuration(s) do a poor job of representing the underlying biological continuum?

t-SNE

MDS

PCA - 4 components

PCA - 5 components

PCA - 6 components

PCA - 7 components

PCA - 8 components

PCA - 9 components

PCA - 10 components

ICA - 4 components

ICA - 5 components

ICA - 6 components

ICA - 7 components

ICA - 8 components

ICA - 9 components

ICA - 10 components

None

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Why do you think these configurations did so poorly to represent the data? *

Questions, comments, concerns? *

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