Nicotine Research Lab Study

This research is studying the effects of a potential new drug for smoking cessation on smokers' well-being and ability to quit smoking for short periods of time. We are looking for smokers who are interested in quitting smoking soon. This experimental drug was developed to reduce cognitive impairment, one symptom of tobacco withdrawal, suggesting it may also help reduce smoking. Although this study is examining the potential short-term effects of a new oral drug, whether or not it helps smokers quit is not yet known. Therefore, this is NOT a treatment trial for those who want to quit immediately.

However, everyone who completes the study will have the option of free Zyban (Bupropion) medication and brief counseling to help them quit permanently. Zyban is an FDA approved medication to help smokers quit smoking. You would not be required to return for these visits if you decide after the end of the study that you wanted to quit on your own.

The research study is composed of 2 study phases that are each 3 weeks long, for a total study length of 6 weeks. Each phase would require that you come in for 2 days during the first and second weeks and then every day, Monday through Friday, during the third week. Most visits will take about 10-15 minutes, with three visits each phase lasting up to an hour. Please note that sessions are only scheduled between 9 AM and 2 PM, Monday through Friday. You would be asked to try to quit smoking during two one-week periods, one involving a placebo and one involving the new study drug that you would use on a daily basis for several weeks.

There would also be an introductory session as well as a mandatory physical examination that includes blood tests and a urine drug screen.

Compensation will be provided for each visit, with payment upon completing the entire 6-week study.

We want to emphasize that this study is only for smokers who are already interested in quitting.

Please fill out the following questions to determine your eligibility for this smoking study.