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How many tamoxifen trials do you carry out annually in your facility? The number may vary from year to year, so please provide an average value.

What is the number of subjects you use per trial?

When the animal is dosed, how much tamoxifen is administered?
What is the number of doses of tamoxifen given daily?
How many days are the animals dosed with tamoxifen?
What is the current dosing method used at your facility for tamoxifen?
What are the reasons for using/preferring this method of dosing?
Can you tell me about the challenges or disadvantages of your current dosing method?
Do you have any experience with oral feeding?
If oral feeding is used, can you tell us about the challenges/drawbacks you faced during oral feeding? If not, what are the reasons for not using oral dosing currently?
If oral feeding is used, is the final animal feed containing the tamoxifen sterilized before use? If so, which sterilization method do you use (e.g. autoclave, gamma sterilization)?
Do you see any benefits to using taste masked tamoxifen micropellets? If so, what are they?
Do you see an advantage in using taste masked, coated micropellets of tamoxifen over powdered tamoxifen from an environmental, health and safety perspective? When tamoxifen is used in micropellets, the risk of contamination is much lower than when it is used in free powder form (e.g. during blending and mixing).
What challenges do you expect when administering micropellets?
What could be done to further improve the taste masked micropellets to better meet your needs?
If oral feeding is not current used, would you consider changing the route of administration (e.g. from IP to oral feeding) using the taste masked micropellets?
Would you consider using tamoxifen micropellets instead of tamoxifen powder/solution if you dose via a feeding tube?
What documentation should be included with the tamoxifen citrate micropellets (MSDS, Certificate of Analysis, Stability data)
In your experience, are there any other active substances which would benefit from being reformulated into taste masked micro pellets for animal research? If so, please specify.
Please provide your contact information if you would like to keep informed about the development of the product and/or if you are happy for further contact (data will be kept confidential)
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