Research projects using UKPSSR data/samples:
- Sjögren's Genetic network (SGENE). National Institute of Health, USA. (PI: K Moser, Oklahoma, US). We contribute all our DNA samples for this international genome-wide association study, and we are currently one of the biggest contributors to the project. This study has identified a number of signals and is now in the validation phase. The latest results will be presented at the American College of Rheumatology Annual Conference in Chicago in Nov 2011.
- Anti-muscarinic receptor antibodies, primary Sjögren's syndrome and autonomic dysfunction (CLRN ID: 7456). Arthritis Research UK. (PI, P Smith, Liverpool). This study has been adopted into the NIHR portfolio. This study aims to determine the diagnostic values of anti-M3R antibodies in PSS and their relationship with autonomic dysfunction in PSS. The experimental work has just been completed, data are currently being analysed.
- United Kingdom Primary Sjögren's Syndrome Cohort - Does fatigue in patients with primary Sjögren's syndrome correlated with general disease activity and damage? (CLRN ID:8594) (PI: W-F Ng, Newcastle). This study investigates the relationship between biological disease activity and levels and characteristics of fatigue in primary Sjögren's syndrome. Study ongoing.
- Assessing the cardiovascular risk of patients with primary Sjögren's syndrome (CLRN ID:7782). British Sjögren Syndrome Association. (PIs: W-F Ng, Newcastle; G Kitas, Dudley; E Price, Swindon; S Bowman, Birmingham). In this study, additional data on cardiovascular risk factor and events will be collected. Pulse-wave velocity and a panel of vascular biomarkers (as surrogate markers of increased cardiovascular risk) will be measured in a subset of patients. Phase I of the study has now been completed and data has been submitted for publication.
- Validation of European primary Sjögren's syndrome disease activity index and patient reported index study. EULAR. (PIs: X Mariette, R. Seror (Paris, France)). In this study, two proposed outcome measure tools will be validated. The recruitment for this study has been completed and the data are being analysed in Paris.
- The prevalence and predictor of autonomic dysfunction in primary Sjögren's syndrome. Newcastle University. (PI: W-F Ng & J Newton, Newcastle). Sample size: 300. The data of this data has been submitted for publication.
- Epigenetic regulation of gene expression in primary Sjögren's syndrome. Sir Jules Thorn Charitable Trust PhD Scholarship. (PI: W-F Ng, Newcastle). Sample size: 50-80. This study aims to investigate the role of epigenetic regulation of candidate genes that are important in PSS pathogenesis.
- Randomised placebo-controlled clinical trial of rituximab in primary Sjögren's syndrome. Arthritis Research UK. (PIs: S Bowman, Birmingham; P Emery, Leeds; C Pitzalis, London). Sample size: 110. Patients with residual oral or salivary gland function will be treated with 2 courses of rituximab or placebo at baseline and at 24 weeks. Primary outcome measures are greater than 20% improvement in oral/ocular function and fatigue. Recruitment started summer 2011.
- Candidate gene association study. Swedish Rheumatism Association. (PI: G Nordmark, Uppsala, Sweden). Sample size: >500, as many as possible. This study seek to validate a set of candidate genes that has been linked to the development of PSS and PSS-associated lymphoma in a Scandinavian cohort. Study ongoing.