Furuta Y, Miura F, Ichise T, Nakayama SMM, Ikenaka Y, Zorigt T, Tsujinouchi M, Ishizuka M, Ito T, Higashi H
A GCDGC-specific DNA (cytosine-5) methyltransferase that methylates the GCWGC sequence on both strands and the GCSGC sequence on one strand.
PLoS ONE, 17(3): e0265225 (2022).
Furuta Y, Tsujinouchi M, Shawa M, Zorigt T, Miyajima Y, Paudel A, Suzuki S, Higashi H
Complete genome sequences of 24 strains of Bacillus cereus isolated from nosocomial infection and bacteremia cases in Japan.
Microbiol. Resour. Announc., Online ahead of print (2022).
Zorigt T, Ito S, Isoda N, Furuta Y, Shawa M, Norov N, Lkham B, Enkhtuya J, Higashi H
Risk factors and spatio-temporal patterns of livestock anthrax in Khuvsgul Province, Mongolia.
PLoS ONE, 16(11): e0260299 (2021).
Zorigt T, Furuta Y, Simbotwe M, Ochi A, Tsujinouchi M, Shawa M, Shimizu T, Isoda N, Enkhtuya J, Higashi H.
Development of ELISA based on Bacillus anthracis capsule biosynthesis protein CapA for naturally acquired antibodies against anthrax.
PLoS ONE, 16(10): e0258317 (2021).
Furuta Y, Cheng C, Zorigt T, Paudel A, Izumi S, Tsujinouchi M, Shimizu T, Meijer WG, Higashi H.
Direct regulons of AtxA, the master virulence regulator of Bacillus anthracis.
mSystems, 6(4): e00291-21 (2021).
Paudel A, Furuta Y, Higashi H.
Silkworm model for Bacillus anthracis infection and virulence determination.
Virulence, 12(1): 2285-2295 (2021).
Shawa M, Furuta Y, Mulenga G, Mubanga M, Mulenga E, Zorigt T, Kaile C, Simbotwe M, Paudel A, Hang’ombe BM, Higashi H
Novel chromosomal insertions of ISEcp1-blaCTX-M-15 and diverse antimicrobial resistance genes in Zambian clinical isolates of Enterobacter cloacae and Escherichia coli.
BMC Antimicrobial Resistance & Infection Control. 10, 79 (2021).
Akamatsu R, Suzuki M, Okinaka K, Sasahara T, Yamane K, Suzuki S, Fujikura D, Furuta Y, Ohnishi N, Esaki M, Shibayama K, Higashi H
A novel sequence type in Bacillus cereus strains associated with nosocomial infections and bacteremia in Japan.
Emerg Infect Dis. 25(5): 883-890 (2019).
Simbotwe M, Mulenga E, Furuta Y, Muuka GM, Hang’ombe BM, Higashi H
Geographic distribution of cattle anthrax in Western Zambia.
Jpn J Vet Res. 67(2): 195-202 (2019).
Toyomane K, Furuta Y, Fujikura D, Higashi H
Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in Bacillus anthracis.
PeerJ. 7:e6718 (2019)
Furuta Y, Harima H, Ito E, Maruyama F, Ohnishi N, Osaki K, Ogawa H, Squarre D, Hang'ombe BM, Higashi H
Loss of bacitracin resistance due to a large genomic deletion among Bacillus anthracis strains.
mSystems. 3:e00182-18 (2018)
Simbotwe M, Fujikura D, Ohnuma M, Omori R, Furuta Y, Muuka GM, Hang’ombe BM, Higashi H
Development and application of a Bacillus anthracis protective antigen domain-1 in-house ELISA for the detection of anti-protective antigen antibodies in cattle in Zambia.
PLoS ONE. 13(10):e0205986 (2018)
Fujikura D, Ikesue M, Endo T, Chiba S, Higashi H, Uede T
Death receptor 6 contributes to autoimmunity in lupus-prone mice.
Nat Commun. 8:13579 (2016)
Fujikura D, Toyomane K, Kamiya K, Muto M, Mifune E, Ohnuma M, Higashi H
ANTXR-1 and -2 independent modulation of a cytotoxicity mediated by anthrax toxin in human cells.
J Vet Med Sci. 78(8):1311-1317 (2016)
Kameoka S, Kameyama T, Hayashi T, Sato S, Ohnishi N, Hayashi T, Murata-Kamiya N, Higashi H, Hatakeyama M, Takaoka A
Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells.
Biomed Res. 37(1):21-27(2016)
Ogawa H, Ohnuma M, Squarre D, Mweene AS, Ezaki T, Fujikura D, Ohnishi N,Thomas Y, Hang’ombe BM, Higashi H
Bacillus cereus from the environment is genetically related to the highly pathogenic B. cereus in Zambia.
J Vet Med Sci. 77(8):993-995 Aug(2015)
Ogawa H, Fujikura D, Ohnuma M, Ohnishi N, Hang’ombe BM, Mimuro H, Ezaki T, Mweene AS, Higashi H
A novel multiplex PCR discriminates Bacillus anthracis and its genetically related strains from other Bacillus cereus group species.
PLoS One. 10(3):e0122004 Mar(2015)
Yabe J, Hamambulu P, Simulundu E, Ogawa H, Kajihara M, Mori-Kajihara A, Changula-Chitanga K, Mwase M, Mweemba-Muwowo M, Chambaro HM, Mataa L, Hang'ombe B, Namangala B, Fandamu P, Sawa H, Takada A, Higashi H, Mweene AS
Pathological and molecular diagnosis of the 2013 African swine fever outbreak in Lusaka, Zambia.
Trop Anim Health Prod. 47(2):459-63 Feb(2015).
Takei Y, Ohnishi N, Kisaka M, Mihara K
Determination of abnormally expressed microRNAs in bone marrow smears from patients with follicular lymphomas.
SpringerPlus 3:288 (2014)
Yamada K, Sudo H, Iwasaki K, Sasaki N, Higashi H, Kameda Y, Ito M, Takahata M, Abumi K, Minami A, Iwasaki N.
Caspase 3 Silencing Inhibits Biomechanical Overload-Induced Intervertebral Disk Degeneration.
Am. J. Pathol.184,753-764 (2014)
Ohnishi N, Maruyama F, Ogawa H, Kachi H, S Yamada, Fujikura D, Nakagawa I, Hang'ombe MB , Thomas Y, Mweene AS, Higashi H
Genome Sequence of Bacillus anthracis Outbreak Strain in Zambia, 2011
Genome Announcement 2(2): e00116-14 March/April (2014).
Manzoor R, Kuroda K, Yoshida R, Tsuda Y, Fujikura D, Miyamoto H, Kajihara M, Kida H and Takada A
Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity.
J Biol Chem. Epub ahead of print Jan (2014).
Fukada K, Fujikura D, Nakayama Y, Kondoh M, Shimada T and Miyazaki T
Enterococcus faecalis FK-23 affects alveolar-capillary permeability to attenuate leukocyte influx in lung after influenza virus infection.
Springerplus 20;2(1):269 Jun (2013).
Fujikura D, Chiba S, Muramatsu D, Kazumata M, Nakayama Y, Kawai T, Akira S, Kida H and Miyazaki T
Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza.
PLoS One 8(2):e55321 Feb (2013).
Sudo H, Yamada K, Iwasaki K, Higashi H, Ito M, Minami A, Iwasaki N
Global identification of genes related to nutrient deficiency in intervertebral disc cells in an experimental nutrient deprivation mode.
PLoS One 8: e58806 (2013).
Hayashi T, Senda M, Morohashi H, Higashi H, Horio M, Kashiba Y, Nagase L, Sasaya D, Shimizu T, Venugopalan N, Kumeta H, Noda NN, Inagaki F, Senda T, Hatakeyama M
Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA.
Cell Host Microbe., 12, 20-33 (2012).
Muto NA, Sunden Y, Hattori T, Fujikura D, Nakayama Y, Miyazaki T, Maruyama M, Kimura T, Sawa H
Pathological examination of lung tissues in influenza a virus-infected mice.
Jpn J Infect Dis. 65(5):383-91 Sep (2012).
Muto NA, Yoshida R, Suzuki T, Kobayashi S, Ozaki H, Fujikura D, Manzoor R, Muramatsu M, Takada A, Kimura T, Sawa H
Inhibitory effects of an M2-specific monoclonal antibody on different strains of influenza A virus.
Jpn J Vet Res. 60(2-3):71-83. Aug (2012).
Hang'ombe MB, Mwansa JC, Muwowo S, Mulenga P, Kapina M, Musenga E, Squarre D, Mataa L, Thomas SY, Ogawa H, Sawa H, Higashi H
Human-animal anthrax outbreak in the Luangwa valley of Zambia in 2011.
Trop Doct. Apr 3 (2012).
Fujikura D, Ito M, Chiba S, Harada T, Perez F, Reed JC, Uede T, Miyazaki T
CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1.
Cell Death Dis.;3:e264 Feb 2 (2012).
Kondoh M, Fukada K, Fujikura D, Shimada T, Suzuki Y, Iwai A, Miyazaki T
Effect of water-soluble fraction from lysozyme-treated Enterococcus faecalis FK-23 on mortality caused by influenza A virus in mice.
Viral Immunol ;25(1):86-90 Feb (2012).
Takahashi A, Tsutsumi R, Kikuchi I, Obuse C, Saito Y, Seidi A, Karisch R, Fernandez M, Cho M, Ohnishi N, Rozenblatt-Rosen O, Meyerson M, Neel BG, Hatakeyama M
SHP2 Tyrosine Phosphatase Convert Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver.
Molecular Cell;43(1):45-56, Jul 8 (2011).
Kim E, Okumura M, Sawa H, Miyazaki T, Fujikura D, Yamada S, Sugahara K, Sasaki M, Kimura T
Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection.
Biochem Biophys Res Commun.;409(4):717-22 Jun 17 (2011).
Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, Goto S, Kameoka S, Fujikura D, Yamada T, Mizutani T, Kazumata M, Sato M, Tanaka J, Asaka M, Ohba Y, Miyazaki T, Imamura M, Takaoka A
ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses.
Nat Immunol.;12(1):37-44 Jan (2011).
Tanaka H, Yoshida M, Nishiumi S, Ohnishi N, Kobayashi K, Ymamoto K, Fujita T, Hatakeyama M, Azuma T
The CagA protein of Helicobacter pylori suppresses the functions of dendritic cell in mice.
Arch Biochem Biophys.;498(1):35-42 Jun 1 (2010).
Murata-Kamiya N, Kikuchi K, Hayashi T, Higashi H, Hatakeyama M
Helicobacter pylori exploits host membrane phosphatidylserine for delivery, localization, and pathophysiological action of the CagA oncoprotein.
Cell Host Microbe, 7, 399-411 (2010).
Lamb A, Yang XD, Tsang YH, Li JD, Higashi H, Hatakeyama M, Peek RM, Blanke SR, Chen LF
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
EMBO Rep., 10, 1242-1249 (2009).
Li HM, Fujikura D, Harada T, Uehara J, Kawai T, Akira S, Reed JC, Iwai A, Miyazaki T
IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation.
Cell Death Differ. ;16(12):1615-21 Dec (2009).
Miura M, Ohnishi N, Tanaka S, Yanagiya K, Hatakeyama M
Different oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice.
Int J Cancer. ;125(11):2497-504 Dec 1 (2009).
Ohnishi N, Yuasa H, Tanaka S, Sawa H, Miura M, Matsui A, Higashi H, Musashi M, Iwabuchi K, Suzuki M, Yamada G, Azuma T, Hatakeyama M
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and haematopoietic neoplasms in mouse.
Proc Natl Acad Sci U S A.;105(3):1003-8 Jan 22 (2008).
Miyamoto D, Miyamoto M, Takahashi A, Yomogita Y, Higashi H, Kondo S, Hatakeyama M
Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.
Oncogene, 27, 3508-3515 (2008).
Kurashima Y, Murata-Kamiya N, Kikuchi K, Higashi H, Azuma T, Kondo S, Hatakeyama M
Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence.
Int. J. Cancer, 122, 823-831 (2008).
Lu H, Saito Y, Umeda M, Murata-Kamiya N, Zhang H, Higashi H, Hatakeyama M
Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.
Cancer Sci., 99, 2004-2011 (2008).
Saadat I, Higashi H, Obuse C, Umeda M, Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S, Hatakeyama M
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.
Nature.;447(7142):330-3 May 17 (2007).
Takeda S, Iwai A, Nakashima M, Fujikura D, Chiba S, Li HM, Uehara J, Kawaguchi S, Kaya M, Nagoya S, Wada T, Yuan J, Rayter S, Ashworth A, Reed JC, Yamashita T, Uede T, Miyazaki T
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma. Anticancer Res.;27(2):761-8 Mar-Apr (2007).
Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek R M. Jr, Azuma T, Hatakeyama M
Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.
Oncogene, 26, 4617-4726 (2007).
Fujikura D
Analysis of the mechanism involved in intra-cellular information transmission through death receptor 6 (DR6), a new apoptosis inducing receptor.
Hokkaido Igaku Zasshi. ;81(5):399-407 Sep (2006).
Tsutsumi R, Takahashi A, Azuma A, Higashi H, Hatakeyama M
FAK is a substrate and downstream effector of SHP-2 complexed with Helicobacter pyloriCagA.
Mol. Cell. Biol., 26, 261-276 (2006).
Ren S, Higashi H, Lu H, Azuma T, Hatakeyama M
Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells.
J. Biol. Chem., 281, 32344-32352 (2006).
Naito M, Yamazaki T, Tsutsumi R, Higashi H, Onoe K, Yamazaki S, Azuma T, Hatakeyama M
Influence of EPIYA-repeat polymorphism on thephosphorylation-dependent biological activity of Helicobacter pylori CagA.
Gastroenterology, 130, 1181-1190 (2006).
Higashi H, Yokoyama K, Fujii Y, Ren S, Yuasa H, Saadat I, Murata-Kamiya N, Azuma T, Hatakeyama M
EPIYA motif is a membrane targeting signal of Helicobacter pylori CagA in mammalian cells.
J. Biol. Chem., 280, 23130-23137 (2005).
Hatakeyama M, Higashi H
Helicobacter pylori CagA - a new paradigm for bacterial carcinogenesis.
Cancer Sci., 96, 835-843 (2005).
Nakano N, Urasawa K, Takagi Y, Saito T, Kaneta S, Ishikawa S, Higashi H, Tsutsui H, Hatakeyama M, Kitabatake A
Downregulation of cyclin-dependent kinase inhibitor; p57(kip2), is involved in the cell cycle progression of vascular smooth muscle cells.
Biochem. Biophys. Res. Commun. 338, 1661-1667 (2005).
Yamazaki S, Yamakawa A, Okuda T, Ohtani M, Suto H, Ito Y, Yamazaki Y, Keida Y, Higashi H, Hatakeyama M, Azuma T
Distinct diversity of vacA, cagA, and cagE genes of Helicobacter pylori associated with peptic ulcer in Japan.
J. Clin. Microbiol., 43, 3906-3916 (2005).
Yokoyama K, Higashi H, Ishikawa S, Fujii Y, Kondo S, Kato H, Azuma T, Wada A, Hirayama T, Aburatani H, Hatakeyama M
Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells.
Proc. Natl. Acad. Sci. USA., 102, 9661-9666 (2005).
Yamazaki S, Kato S, Matsukura N, Ohtani M, Ito Y, Suto H, Yamazaki Y, Yamakawa A, Tokudome S, Higashi H, Hatakeyama M, Azuma T
Identification of Helicobacter pylori and the cagA genotype in gastric biopsies using highly sensitive real-time PCR as a new diagnostic tool.
FEMS Immunol. Med. Microbiol., 44, 261-268 (2005).
Miyazaki T, Shen M, Fujikura D, Tosa N, Kim HR, Kon S, Uede T, Reed JC
Functional role of death-associated protein 3 (DAP3) in anoikis.
J Biol Chem.;279(43):44667-72 Oct 22 (2004).
Higashi H, Nakaya A, Tsutsumi R, Yokoyama K, Fujii Y, Ishikawa S, Higuchi M, Takahashi A, Kurashima Y, Teishikata Y, Tanaka S, Azuma T, Hatakeyama M
Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation.
J. Biol. Chem., 279, 17205-17216 (2004).
Ozawa H, Ashizawa S, Naito M, Yanagihara M, Ohnishi N, Maeda T, Matsuda Y, Jo M,Higashi H, Kakita A, Hatakeyama M
Paired-like homeodomain protein ESXR1 possesses a cleavable C-terminal region that inhibits cyclin degradation.
Oncogene. ;23(39):6590-602 Aug 26 (2004).
Azuma T, Yamakawa A, Yamazaki S, Ohtani M, Ito Y, Muramatsu A, Suto H, Yamazaki Y, Keida Y, Higashi H, Hatakeyama M
Distinct diversity of the cag pathogenicity island among Helicobacter pylori strains in Japan.
J. Clin. Microbiol., 42, 2508-2517 (2004).
Azuma T, Ohtani M, Yamazaki Y, Higashi H, Hatakeyama M
Meta-analysis of the relationship between CagA seropositivity and gastric cancer.
Gastroenterology, 126, 1926-1927 (2004).
Higuch M, Tsutsumi R, Higashi H, Hatakeyama M
Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity.
Cancer Sci., 95, 442-447 (2004).
Azuma T, Yamazaki S, Yamakawa A, Ohtani M, Muramatsu A, Suto H, Ito Y, Dojo M, Yamazaki Y, Kuriyama M, Keida Y, Higashi H, Hatakeyama M
Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer.
J. Infect. Dis., 189, 820-827 (2004).
Zhou W, Yamazaki S, Yamakawa A, Ohtani M, Ito Y, Keida Y, Higashi H, Hatakeyama M, Si J, Azuma T
The diversity of vacA and cagA genes of Helicobacter pylori in East Asia.
FEMS Immunol. Med. Microbiol., 40, 81-87 (2004).
Rung-ruangkijkrai T, Fujikura D, Kon Y, Iwanaga T
Cellular expression of src-suppressed C kinase substrate (SSeCKS) in the peripheral nervous system andorgans
Biomedical Research (3)155-64 Jun 25 (2004).
Rung-ruangkijkrai T, Fujikura D, Kitamura H, Saito M, Iwanaga T
The expression of src-suppressed C kinase substrate (SSeCKS) and uptake of exogenous particles in endothelial and reticular cells.
Arch Histol Cytol. ;67(2):135-47 Jun (2004).
Azuma T, Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Dojo M, Yamazaki Y, Higashi H, Hatakeyama M
The effects of cure of Helicobacter pylori infection on the signal transduction of gastric epithelial cells.
Aliment. Pharmacol. Ther., 18 (Suppl 1), 39-44 (2003).
Umehara S, Higashi H, Ohnishi N, Asaka M, Hatakeyama M
Effects of Helicobacter pylori CagA protein on the growth and survival of B lymphocytes, the origin of MALT lymphoma.
Oncogene. ;22(51):8337-42 Nov 13 (2003).
Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M
Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages.
Arch Histol Cytol. ;66(1):53-62 Mar (2003).
Takebayashi T, Higashi H, Sudo H, Ozawa H, Suzuki E, Shirado O, Katoh H, Hatakeyama M
NF-kB-dependent induction of cyclin D1 by pRB family proteins and tumor-derived pRB mutants.
J. Biol. Chem., 278, 14897-14905 (2003).
Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M
Attenuation of helicobacter pylori CagA-SHP-2 signaling by interaction between CagA and C-terminal Src kinase.
J. Biol. Chem., 278, 3664-3370 (2003).
Yamazaki S, Yamakawa A, Ito Y, Ohtani M, Higashi H, Hatakeyama M, Azuma T
The CagA protein of Helicobacter pylori is translocated into epithelial cells and binds to SHP-2 in human gastric mucosa.
J. Infect. Dis., 187, 334-337 (2003).
Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M
SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein.
Science, 295, 683-686 (2002).
Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, Hatakeyama M
Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.
Proc. Natl. Acad. Sci. USA., 99,14428-14433 (2002).
Kitamura H, Okita K, Fujikura D, Mori K, Iwanaga T, Saito M
Induction of Src-suppressed C kinase substrate (SSeCKS) in vascular endothelial cells by bacterial lipopolysaccharide.
J Histochem Cytochem. ;50(2):245-55 Feb (2002).
Yamada M, Kondo T, Ashizawa S, Takebayashi T, Higashi H, Hatakeyama M
Role of pRB-family/E2F complex in the inhibition of IL-3-dependent lymphoid cell proliferation.
Cytokine., 17, 91-97 (2002).
Kondo T, Higashi H, Nishizawa H, Ishikawa S, Ashizawa S, Yamada M, Makita Z, Koike T, Hatakeyama M
Involvement of pRB-related p107 protein in the inhibition of S phase progression in response to genotoxic stress.
J. Biol. Chem., 276, 17559-17567 (2001).
Ashizawa S, Nishizawa H, Yamada M, Higashi H, Kondo T, Ozawa H, Kakita A, Hatakeyama M
Collective inhibition of pRB family proteins by phosphorylation in cells with p16INK4a loss or cyclin E overexpression.
J. Biol. Chem., 276, 11362-11370 (2001).
金平克史 北村浩 岩永敏彦 藤倉大輔 森松正美 斉藤昌之
新しいIκBファミリータンパク質MAILの同定と発現・機能解析
獣医生化学 Vol.138 (2) 19-25, (2001).
Mizuguchi R, Noto S, Yamada M, Ashizawa S, Higashi H, Hatakeyama M
Ras and signal transducer and activator of transcription (STAT) are essential and sufficient downstream components of Janus kinases in cell proliferation.
Jpn. J. Cancer Res., 91, 527-533 (2000).
Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Hatakeyama M
Human p55CDC/Cdc20 associates with cyclin A and is phosphorylated by cyclin A-Cdk2 complex.
Biochem. Biophys. Res.Commun., 268, 530-534 (2000).
Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Yamada M, Hatakeyama M
b3-endonexin as a novel inhibitor of cyclin A-associated kinase.
Biochem. Biophys. Res. Commun., 267, 947-952 (2000).
Aso T, Yamazaki K, Amimoto K, Kuroiwa A, Higashi H, Matsuda Y, Kitajima S, Hatakeyama M
Identification and characterization of elongin A2, a new member of the elongin family of transcription elongation factors, specifically expressed in the testis.
J. Biol. Chem., 275, 6546-6552 (2000).
Mori A, Higashi H, Hoshikawa Y, Imamura M, Asaka M, Hatakeyama M
Granulocytic differentiation of myeloid progenitor cells by p130, the retinoblastoma tumor suppressor homologue.
Oncogene, 18, 6209-6221 (1999).
Hatakeyama S, Kitagawa M, Nakayama K, Shirane M, Matsumoto M, Hattori K, Higashi H, Nakano H, Okumura K, Onoe K, Good R. A, Nakayama K
Ubiquitin-dependent degradation of IkBa is mediated by a ubiquitin ligase Skp1/Cul1/F-box protein FWD1.
Proc. Natl. Acad. Sci. USA, 96, 3859-3863 (1999).
Terano T, Tanaka T, Tamura Y, Kitagawa M, Higashi H, Saito Y, Hirai A
Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex.
Biochem. Biophys. Res .Commun., 254, 502-506 (1999).
Tanaka T, Tatsuno I, Noguchi Y, Uchida D, Oeda T, Narumiya S, Yasuda T, Higashi H, Kitagawa M, Nakayama K, Saito Y, Hirai A
Activation of cyclin-dependent kinase 2 (Cdk2) growth-stimulated rat astrocytes.
J. Biol. Chem., 273, 26772-26778 (1998).
Higashi H, Suzuki-Takahashi I, Yoshida E, Nishimura S, Kitagawa M
Expression of p16INK4a suppresses the unbounded and anchorage-independent growth of a glioblastoma cell line that lacks p16INK4a.
Biochem. Biophys. Res. Commun., 231, 743-750 (1997).
Suzuki-Takahashi I, Higashi H, Yoshida E, Nishimura S, Kitagawa M
Effects of exogenous p16INK4a on growth of cells with various status of cell-cycle regulators.
Biochem. Biophys. Res. Commun., 234, 386-392 (1997).
Higashi H, Suzuki-Takahashi I, Saitoh S, Segawa K, Taya Y, Okuyama A, Nishimura S, Kitagawa M
Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin H.
Eur. J. Biochem., 237, 460-467 (1996).
Kitagawa M, Higashi H, Jung H-K, Suzuki-Takahashi I, Ikeda M, Tamai K, Kato J, Segawa K, Yoshida E, Nishimura S, Taya Y
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.
EMBO J., 15, 7060-7069 (1996).
Higashi H, Suzuki-Takahashi I, Taya Y, Segawa K, Nishimura S, Kitagawa M
Differences in substrate specificity between Cdk2-cyclin A and Cdk2-cyclin E in vitro.
Biochem. Biophys. Res. Commun., 216, 520-525 (1995).
Suzuki-Takahashi I, Kitagawa M, Saijo M, Higashi H, Ogino H, Matsumoto H, Taya Y, Nishimura S, Okuyama A
The interactions of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase.
Oncogene, 10, 1691-1698 (1995).
Kotani S, Endo T, Kitagawa M, Higashi H, Onaya T
A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly transformed rat thyroid (FRTL-Tc) cell line.
Oncogene, 10, 663-669 (1995).
Kitagawa M, Higashi H, Suzuki-Takahashi I, Segawa K, Hanks SK, Taya Y, Nishimura S, Okuyama A
Phosphorylation of E2F-1 by cyclin A-cdk2.
Oncogene, 10, 229-236 (1995).
Kitagawa M, Higashi H, Suzuki-Takahashi I, Okabe T, Ogino H, Taya Y, Nishimura S, Okuyama A
A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression.
Oncogene, 9, 2549-2557 (1994).
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