Table 1 Known Musashi Targets

Target mRNA	Up-/down- regulation	Cell type	Method(s) of identification	Effect	Reference
TTK69	Down	Drosophila SOP precursors	Candidate gene	Asymmetric cell fate	Okabe et al. 2001
Numb	Down	NIH 3T3 cells	Msi target sequences in 3’-UTR	Notch upregulation	Imai et al. 2001
Numb	Down	CML	Candidate gene	Blast crisis	Ito et al. 2010
CDKN1A	Down	HEK293 cells	Candidate gene	Cell cycle progression, proliferation	Battelli et al. 2006
c-mos	Up	Xenopus oocytes	Yeast 3-hybrid screen	Meiotic cycle progression	Charlesworth et al. 2006
Robo3/Rig1	Up	Murine precerebellar neurons	Candidate gene	Axonal crossing	Kuwako et al. 2010
arx-1, arx-2, arx-3 (encode Arp2/3 subunits)	Down	C. elegans AVA interneurons	Candidate gene	Time-dependent memory loss	Hadziselimovic et al. 2014
doublecortin	Down	Neuro2A cells	mRNA display screen	Unknown	Horisawa et al. 2009
NF-YA	Down	SUM159PT breast cancer cell line	Msi target sequences in 3’-UTR	26S proteasome downregulation	Lagadec et al. 2014
Smad3	Down	Murine HSCs	HITS-CLIP	HSC maintenance	Park et al. 2014
Jagged1	Down	293T cells	Msi target sequences in 3’-UTR	Notch signaling upregulation	Katz et al. 2014
PTEN	Down	MSI2-overexpressing intestinal epithelium	CLIP-Seq	Crypt fission and expansion	Wang et al. 2015
Hoxa9, Myc, Ikzf2	Up	Mixed-lineage leukemia (MLL-AF9)	HITS-CLIP, RNA-Seq, RNA-IP	Maintenance of leukemia self-renewal	Park et al. 2015
Tetraspanin3	Up	Acute myelogenous leukemia	Microarray	AML propagation, chemokine response	Kwon et al. 2015

Abbreviations

CLIP-Seq, crosslinking immunoprecipitation sequencing

CML, chronic myeloid leukemia

HITS-CLIP, high-throughput sequencing RNA isolated by crosslinking immunoprecipitation

HSC, hematopoietic stem cell

SOP, sensory organ progenitor

UTR, untranslated region