2020
*Rempel, S., Gati, C., Nijland, M., Thangaratnarajah, C., Karyolaimos, A., de Gier, J. W., et al. (2020). A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds. Nature, 3(W1), 1–4.
*Slotboom, D. J., Ettema, T. W., Nijland, M., & Thangaratnarajah, C. (2020). Bacterial multi-solute transporters. FEBS Letters, 1873–3468.13912.
*Arkhipova, V., Guskov, A., & Slotboom, D. J. (2020). Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment. Nature Communications, 11(1), 998–9.
Faustino, I., Abdizadeh, H., Souza, P. C. T., Jeucken, A., Stanek, W. K., Guskov, A., Slotboom, D. J. & Marrink S. J. (2020). Membrane mediated toppling mechanism of the folate energy coupling factor transporter. Nature Communications, 11(1), 1763–9.
*Garaeva, A. A., & Slotboom, D. J. (2020). Elevator-type mechanisms of membrane transport. Biochemical Society Transactions, 48(3), 1227–1241.
Jochim, A., Adolf, L., Belikova, D., Schilling, N. A., Setyawati, I., Chin, D., Meyers, S., Verhamme, P., Heinrichs, D.E., Slotboom, D.J., & Simon Heilbronner. (2020). An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis. eLife, 9, 2345.
*Stetsenko, A., Singh, R., Jaehme, M., Guskov, A., & Slotboom, D. J. (2020). Structural and Functional Characterization of NadR from Lactococcus lactis. Molecules, 25(8), 1940.
2019
Leth, M. L., Ejby, M., Madland, E., Kitaoku, Y., Slotboom, D. J., Guskov, A., ... & Abou Hachem, M. (2019). Molecular insight into a new low‐affinity xylan binding module from the xylanolytic gut symbiont Roseburia intestinalis. The FEBS journal.
*Garaeva, A. A., Guskov, A., Slotboom, D. J., & Paulino, C. (2019). A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2. Nature communications, 10(1), 1-8.
*Arkhipova, V., Trinco, G., Ettema, T. W., Jensen, S., Slotboom, D. J., & Guskov, A. (2019). Binding and transport of D-aspartate by the glutamate transporter homolog GltTk. Elife, 8, e45286.
Ejby, M., Guskov, A., Pichler, M. J., Zanten, G. C., Schoof, E., Saburi, W., ... & Abou Hachem, M. (2019). Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β‐mannan possess distinct manno‐oligosaccharide‐binding profiles. Molecular Microbiology, 112(1), 114-130.
*Lolkema, J. S., & Slotboom, D. J. (2019). Models to determine the kinetic mechanisms of ion-coupled transporters. The Journal of General Physiology, 151(3), 369–380. http://doi.org/10.1085/jgp.201812055
*Rempel, S., Stanek, W. K., & Slotboom, D. J. (2019). Energy-Coupling Factor-Type ATP-Binding Cassette Transporters. Annual Review of Biochemistry, 88(1),
2018
*Garaeva, A. A., Oostergetel, G. T., Gati, C., Guskov, A., Paulino, C., & Slotboom, D. J. (2018). Cryo-EM structure of the human neutral amino acid transporter ASCT2. Nature Structural & Molecular Biology, 25(6), 515–521. http://doi.org/10.1038/s41594-018-0076-y
Hoorens, M. W. H., Fu, H., Duurkens, R. H., Trinco, G., Arkhipova, V., Feringa, B. L., et al. (2018). Glutamate Transporter Inhibitors with Photo-Controlled Activity. Advanced Therapeutics, 1(2), 1800028. http://doi.org/10.1002/adtp.201800028
*Rempel, S., Colucci, E., de Gier, J. W., Guskov, A., & Slotboom, D. J. (2018). Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM. Nature Communications, 9(1), 3038. http://doi.org/10.1038/s41467-018-05441-9
*Santos, J. A., Rempel, S., Mous, S. T., Pereira, C. T., Beek, ter, J., de Gier, J.-W., et al. (2018). Functional and structural characterization of an ECF-type ABC transporter for vitamin B12. eLife, 7, 213. http://doi.org/10.7554/eLife.35828
*Jaehme, M., Singh, R., Garaeva, A. A., Duurkens, R. H., & Slotboom, D. J. (2017). PnuT uses a facilitated diffusion mechanism for thiamine uptake. The Journal of General Physiology, 112, jgp.201711850. http://doi.org/10.1085/jgp.201711850
2017
*Arkhipova, V., Guskov, A., & Slotboom, D. J. (2017). Analysis of the quality of crystallographic data and the limitations of structural models. The Journal of General Physiology, 149(12), 1091–1103. http://doi.org/10.1085/jgp.201711852
Gati, C., Stetsenko, A., Slotboom, D. J., Scheres, S. H. W., & Guskov, A. (2017). The structural basis of proton driven zinc transport by ZntB. Nature Communications, 8(1), 1313. http://doi.org/10.1038/s41467-017-01483-7
*Goudsmits, J. M. H., Slotboom, D. J., & van Oijen, A. M. (2017). Single-molecule visualization of conformational changes and substrate transport in the vitamin B-12 ABC importer BtuCD-F. Nature Communications, 8(1). http://doi.org/10.1038/s41467-017-01815-7
Baumgarten, T., Schlegel, S., Wagner, S., Löw, M., Eriksson, J., Bonde, I., et al. (2017). Isolation and characterization of the E. coli membrane protein production strain Mutant56(DE3). Scientific Reports, 7, 45089. http://doi.org/10.1038/srep45089
*Goudsmits, J. M. H., van Oijen, A. M., & Slotboom, D. J. (2017). Single-Molecule Fluorescence Studies of Membrane Transporters Using Total Internal Reflection Microscopy. Methods in Enzymology, 594, 101–121. http://doi.org/10.1016/bs.mie.2017.05.009
Hjelm, A., Karyolaimos, A., Zhang, Z., Rujas, E., Vikström, D., Slotboom, D. J., & de Gier, J.-W. (2017). Tailoring Escherichia coli for the l-Rhamnose PBAD Promoter-Based Production of Membrane and Secretory Proteins. ACS Synthetic Biology, 6(6), 985–994. http://doi.org/10.1021/acssynbio.6b00321
Lohse, J., Swier, L. J. Y. M., Oudshoorn, R. C., Médard, G., Kuster, B., Slotboom, D. J., & Witte, M. D. (2017). Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides. Bioconjugate Chemistry, 28(4), 913–917. http://doi.org/10.1021/acs.bioconjchem.7b00110
*Lolkema, J. S., & Slotboom, D. J. (2017). Structure and elevator mechanism of the Na(+)-citrate transporter CitS. Current Opinion in Structural Biology, 45, 1–9. http://doi.org/10.1016/j.sbi.2016.10.004
*Monjas, L., Swier, L. J. Y. M., Setyawati, I., Slotboom, D. J., & Hirsch, A. K. H. (2017). Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine. ChemMedChem, 44, 2455. http://doi.org/10.1002/cmdc.201700440
*Swier, L. J. Y. M., Monjas, L., Reessing, F., Oudshoorn, R. C., Aisyah, Primke, T., et al. (2017). Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations. Medchemcomm, 8(5), 1121–1130. http://doi.org/10.1039/c7md00079k
2016
* Guskov, A., Jensen, S, Faustino, I, Marrink, S.J. & Slotboom, D. J. (2016). Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk. Nature Communications, 7, 13420. DOI: 10.1038/ncomms13420
* Lolkema, J.S. and Slotboom, D.J. (2016) Structure and elevator mechanism of the Na+-citrate transporter CitS. Current Opinion in Structural Biology (accepted for publication)
Ejby, M., Fredslund, F., Andersen, J. M., Vujičić-Žagar, A., Henriksen, J. R., Andersen, T. L., et al. (2016). An ATP Binding Cassette Transporter Mediates the Uptake of α-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates. The Journal of Biological Chemistry, 291(38), 20220–20231.
* Swier, L. J. Y. M., Guskov, A., & Slotboom, D. J. (2016). Structural insight in the toppling mechanism of an energy-coupling factor transporter. Nature Communications, 7, 11072. http://doi.org/10.1038/ncomms11072
*Jaehme, M., Guskov, A., & Slotboom, D. J. (2016). Pnu Transporters: Ain't They SWEET? Trends in Biochemical Sciences, 41(2), 117–118. doi:10.1016/j.tibs.2015.11.013
*Monjas, L., Swier, L. J. Y. M., de Voogd, A. R., Oudshoorn, R. C., Hirsch, A. K. H., and D. J. Slotboom (2016) Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria. Med. Chem. Commun. 7, 966-971
2015
*Hänelt, I., Jensen, S., Wunnicke, D., & Slotboom, D. J. (2015). Low Affinity and Slow Na+ Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh. The Journal of Biological Chemistry, 290(26), 15962–15972. http://doi.org/10.1074/jbc.M115.656876
* Jaehme, M., & Slotboom, D. J. (2015). Structure, function, evolution, and application of bacterial Pnu-type vitamin transporters. Biological Chemistry, 396(9-10), 955–966. doi:10.1515/hsz-2015-0113
*Jaehme, M., Guskov, A., & Slotboom, D. J. (2015). The twisted relation between Pnu and SWEET transporters. Trends in Biochemical Sciences, 40(4), 183–188. http://doi.org/10.1016/j.tibs.2015.02.002
*Lolkema, J. S., & Slotboom, D. J. (2015). The Hill analysis and co-ion-driven transporter kinetics. The Journal of General Physiology, 145(6), 565–574. http://doi.org/10.1085/jgp.201411332
Fulyani, F., Schuurman-Wolters, G. K., Slotboom, D. J., & Poolman, B. (2015). Relative Rates of Amino Acid Import via the ABC Transporter GlnPQ Determine the Growth Performance of Lactococcus lactis. Journal of Bacteriology, 198(3), 477–485. doi:10.1128/JB.00685-15
*Majsnerowska, M., Beek, ter, J., Stanek, W. K., Duurkens, R. H., & Slotboom, D. J. (2015). Competition between Different S-Components for the Shared Energy Coupling Factor Module in Energy Coupling Factor Transporters. Biochemistry, 54(31), 4763–4766. http://doi.org/10.1021/acs.biochem.5b00609
*Swier, L. J. Y. M., Monjas, L., Guskov, A., de Voogd, A. R., Erkens, G. B., Slotboom, D. J., & Hirsch, A. K. H. (2015). Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine. Chembiochem : a European Journal of Chemical Biology, 16(5), 819–826. http://doi.org/10.1002/cbic.201402673
Zhang, Z., Kuipers, G., Niemiec, Ł., Baumgarten, T., Slotboom, D. J., de Gier, J.-W., & Hjelm, A. (2015). High-level production of membrane proteins in E. coli BL21(DE3) by omitting the inducer IPTG. Microbial Cell Factories, 14(1), 142. doi:10.1186/s12934-015-0328-z
2014
*Beek, ter, J., Guskov, A., & Slotboom, D. J. (2014). Structural diversity of ABC transporters. The Journal of General Physiology, 143(4), 419–435. doi:10.1085/jgp.201411164
*Jaehme, M., & Slotboom, D. J. (2015 echt uitgekomen!). Diversity of membrane transport proteins for vitamins in bacteria and archaea. Biochimica Et Biophysica Acta. doi:10.1016/j.bbagen.2014.05.006
*Jaehme, M., Guskov, A., & Slotboom, D. J. (2014). Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog. Nature Structural & Molecular Biology. doi:10.1038/nsmb.2909
*Slotboom, D. J. (2014). Structural and mechanistic insights into prokaryotic energy-coupling factor transporters. Nature Reviews. Microbiology, 12(2), 79–87. doi:10.1038/nrmicro3175
2013
Ejby, M., Fredslund, F., Vujicic - Zagar, A., Svensson, B., Slotboom, D. J. & Abou Hachem, M. (2013). Structural basis for arabinoxylo-oligosaccharide capture by the probiotic Bifidobacterium animalis subsp lactis Bl-04 Molecular Microbiology. 90 (5), 1100-1112.
*Erkens, G.B., Hänelt, I., Goudsmits, J., Slotboom, D. J., & Van Oijen, A.M. (2013). Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters. Nature 502, 119-123.
*Jensen, S., Guskov, A., Rempel, S., Hänelt, I., & Slotboom, D. J. (2013). Crystal structure of a substrate-free aspartate transporter. Nature structural & molecular biology. 20(10): 1224-1226; doi:10.1038/nsmb.2663
*Hänelt, I., Wunnicke, D., Bordignon, E., Steinhoff, H.-J., & Slotboom, D. J. (2013). Conformational heterogeneity of the aspartate transporter Glt(Ph). Nature structural & molecular biology, 20(2), 210–214. doi:10.1038/nsmb.2471
Fulyani, F., Schuurman-Wolters, G. K., Zagar, A. V., Guskov, A., Slotboom, D. J., & Poolman, B. (2013). Functional Diversity of Tandem Substrate-Binding Domains in ABC Transporters from Pathogenic Bacteria. Structure (London, England : 1993). doi:10.1016/j.str.2013.07.020
Kolbusz, M. A., Slotboom, D. J., & Lolkema, J. S. (2013). Genomic distribution of the small multidrug resistance protein EmrE over 29 Escherichia coli strains reveals two forms of the protein. The FEBS journal, 280(1), 244–255. doi:10.1111/febs.12065
*Majsnerowska, M., Hänelt, I., Wunnicke, D., Schäfer, L. V., Steinhoff, H.-J., & Slotboom, D. J. (2013). Substrate-induced conformational changes in the S-component ThiT from an energy coupling factor transporter. Structure (London, England : 1993), 21(5), 861–867. doi:10.1016/j.str.2013.03.007
2012
*Erkens, G. B., Majsnerowska, M., Beek, ter, J., & Slotboom, D. J. (2012). Energy coupling factor-type ABC transporters for vitamin uptake in prokaryotes. Biochemistry, 51(22), 4390–4396. doi:10.1021/bi300504v
Schlegel, S., Löfblom, J., Lee, C., Hjelm, A., Klepsch, M., Strous, M., Drew, D., Slotboom, D. J., & De Gier, J. W. (2012). Optimizing membrane protein overexpression in the Escherichia coli strain Lemo21(DE3). Journal of molecular biology, 423(4), 648–659. doi:10.1016/j.jmb.2012.07.019
Kolbusz, M. A., Slotboom, D. J., & Lolkema, J. S. (2012). Role of individual positive charges in the membrane orientation and activity of transporters of the small multidrug resistance family. Biochemistry, 51(44), 8867–8876. doi:10.1021/bi300854c
*Berntsson, R. P.-A., Beek, ter, J., Majsnerowska, M., Duurkens, R. H., Puri, P., Poolman, B., & Slotboom, D. J. (2012a). Structural divergence of paralogous S components from ECF-type ABC transporters. Proceedings of the National Academy of Sciences of the United States of America, 109(35), 13990–13995. doi:10.1073/pnas.1203219109
Berntsson, R. P.-A., Schuurman-Wolters, G. K., Dunny, G., Slotboom, D. J., & Poolman, B. (2012b). Structure and mode of peptide binding of pheromone receptor PrgZ. The Journal of biological chemistry, 287(44), 37165–37170. doi:10.1074/jbc.M112.386334
2011
*Klepsch, M. M., Kovermann, M., Löw, C., Balbach, J., Permentier, H. P., Fusetti, F., De Gier, J. W., Slotboom, D. J., & Berntsson, R. P.-A. (2011). Escherichia coli peptide binding protein OppA has a preference for positively charged peptides. Journal of molecular biology, 414(1), 75–85. doi:10.1016/j.jmb.2011.09.043
*Berntsson, R. P.-A., Thunnissen, A.-M. W. H., Poolman, B., & Slotboom, D. J. (2011). Importance of a hydrophobic pocket for peptide binding in lactococcal OppA. Journal of bacteriology, 193(16), 4254–4256. doi:10.1128/JB.00447-11
*Steen, A., Wiederhold, E., Gandhi, T., Breitling, R., & Slotboom, D. J. (2011). Physiological adaptation of the bacterium Lactococcus lactis in response to the production of human CFTR. Molecular & cellular proteomics : MCP, 10(7), M000052MCP200. doi:10.1074/mcp.M000052-MCP200
*Beek, ter, J., Duurkens, R. H., Erkens, G. B., & Slotboom, D. J. (2011). Quaternary structure and functional unit of energy coupling factor (ECF)-type transporters. The Journal of biological chemistry, 286(7), 5471–5475. doi:10.1074/jbc.M110.199224
*Erkens, G. B., Berntsson, R. P.-A., Fulyani, F., Majsnerowska, M., Vujičić-Žagar, A., Beek, ter, J., Poolman, B., & Slotboom, D. J. (2011). The structural basis of modularity in ECF-type ABC transporters. Nature structural & molecular biology, 18(7), 755–760. doi:10.1038/nsmb.2073
2010
Berntsson, R. P.-A., Smits, S. H. J., Schmitt, L., Slotboom, D. J., & Poolman, B. (2010). A structural classification of substrate-binding proteins. FEBS letters, 584(12), 2606–2617. doi:10.1016/j.febslet.2010.04.043
*Groeneveld, M., Weme, R. G. J. D. O., Duurkens, R. H., & Slotboom, D. J. (2010). Biochemical characterization of the C4-dicarboxylate transporter DctA from Bacillus subtilis. Journal of bacteriology, 192(11), 2900–2907. doi:10.1128/JB.00136-10
*Erkens, G. B., & Slotboom, D. J. (2010). Biochemical characterization of ThiT from Lactococcus lactis: a thiamin transporter with picomolar substrate binding affinity. Biochemistry, 49(14), 3203–3212. doi:10.1021/bi100154r
Wolters, J. C., Berntsson, R. P.-A., Gul, N., Karasawa, A., Thunnissen, A.-M. W. H., Slotboom, D. J., & Poolman, B. (2010). Ligand binding and crystal structures of the substrate-binding domain of the ABC transporter OpuA. PloS one, 5(4), e10361. doi:10.1371/journal.pone.0010361
*Groeneveld, M., & Slotboom, D. J. (2010). Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph). Biochemistry, 49(17), 3511–3513. doi:10.1021/bi100430s
Kolbusz, M. A., Horst, ter, R., Slotboom, D. J., & Lolkema, J. S. (2010). Orientation of small multidrug resistance transporter subunits in the membrane: correlation with the positive-inside rule. Journal of molecular biology, 402(1), 127–138. doi:10.1016/j.jmb.2010.07.019
*Wiederhold, E., Veenhoff, L. M., Poolman, B., & Slotboom, D. J. (2010). Proteomics of Saccharomyces cerevisiae Organelles. Molecular & cellular proteomics : MCP, 9(3), 431–445. doi:10.1074/mcp.R900002-MCP200
Schlegel, S., Klepsch, M., Gialama, D., Wickström, D., Slotboom, D. J., & de Gier, J.-W. (2010). Revolutionizing membrane protein overexpression in bacteria. Microbial biotechnology, 3(4), 403–411. doi:10.1111/j.1751-7915.2009.00148.x
Bechtluft, P., Kedrov, A., Slotboom, D. J., Nouwen, N., Tans, S. J., & Driessen, A. J. M. (2010). Tight hydrophobic contacts with the SecB chaperone prevent folding of substrate proteins. Biochemistry, 49(11), 2380–2388. doi:10.1021/bi902051e
2009
Rodionov, D. A., Hebbeln, P., Eudes, A., Beek, ter, J., Rodionova, I. A., Erkens, G. B., Slotboom, D. J., Gelfand, M. S., Osterman, A. L., Hanson, A. D., & Eitinger, T. (2009). A novel class of modular transporters for vitamins in prokaryotes. Journal of bacteriology, 191(1), 42–51. doi:10.1128/JB.01208-08
*Berntsson, R. P.-A., Alia Oktaviani, N., Fusetti, F., Thunnissen, A.-M. W. H., Poolman, B., & Slotboom, D. J. (2009a). Selenomethionine incorporation in proteins expressed in Lactococcus lactis. Protein science : a publication of the Protein Society, 18(5), 1121–1127. doi:10.1002/pro.97
*Berntsson, R. P.-A., Doeven, M. K., Fusetti, F., Duurkens, R. H., Sengupta, D., Marrink, S.-J., Thunnissen, A. M. W. H., Poolman, B., & Slotboom, D. J. (2009b). The structural basis for peptide selection by the transport receptor OppA. The EMBO journal, 28(9), 1332–1340. doi:10.1038/emboj.2009.65
*Wiederhold, E., Gandhi, T., Permentier, H. P., Breitling, R., Poolman, B., & Slotboom, D. J. (2009). The yeast vacuolar membrane proteome. Molecular & cellular proteomics : MCP, 8(2), 380–392. doi:10.1074/mcp.M800372-MCP200
2008
Lolkema, J. S., Dobrowolski, A., & Slotboom, D. J. (2008). Evolution of antiparallel two-domain membrane proteins: tracing multiple gene duplication events in the DUF606 family. Journal of molecular biology, 378(3), 596–606. doi:10.1016/j.jmb.2008.03.005
Eudes, A., Erkens, G. B., Slotboom, D. J., Rodionov, D. A., Naponelli, V., & Hanson, A. D. (2008). Identification of genes encoding the folate- and thiamine-binding membrane proteins in Firmicutes. Journal of bacteriology, 190(22), 7591–7594. doi:10.1128/JB.01070-08
Geertsma, E. R., Groeneveld, M., Slotboom, D. J., & Poolman, B. (2008). Quality control of overexpressed membrane proteins. Proceedings of the National Academy of Sciences of the United States of America, 105(15), 5722–5727. doi:10.1073/pnas.0802190105
*Slotboom, D. J., Duurkens, R. H., Olieman, K., & Erkens, G. B. (2008). Static light scattering to characterize membrane proteins in detergent solution. Methods (San Diego, Calif.), 46(2), 73–82. doi:10.1016/j.ymeth.2008.06.012
Lolkema, J. S., & Slotboom, D. J. (2008). The major amino acid transporter superfamily has a similar core structure as Na+-galactose and Na+-leucine transporters. Molecular membrane biology, 25(6-7), 567–570. doi:10.1080/09687680802541177
Wagner, S., Klepsch, M. M., Schlegel, S., Appel, A., Draheim, R., Tarry, M., Högbom, M., Van Wijk, K. J., Slotboom, D. J., Persson, J. O., & de Gier, J.-W. (2008). Tuning Escherichia coli for membrane protein overexpression. Proceedings of the National Academy of Sciences of the United States of America, 105(38), 14371–14376. doi:10.1073/pnas.0804090105
2007
*Duurkens, R. H., Tol, M. B., Geertsma, E. R., Permentier, H. P., & Slotboom, D. J. (2007). Flavin binding to the high affinity riboflavin transporter RibU. The Journal of biological chemistry, 282(14), 10380–10386. doi:10.1074/jbc.M608583200
Jong, W. S. P., Hagen-Jongman, ten, C. M., Blaauwen, den, T., Slotboom, D. J., Tame, J. R. H., Wickström, D., de Gier, J.-W., Otto, B. O., & Luirink, J. (2007). Limited tolerance towards folded elements during secretion of the autotransporter Hbp. Molecular microbiology, 63(5), 1524–1536. doi:10.1111/j.1365-2958.2007.05605.x
*Groeneveld, M., & Slotboom, D. J. (2007). Rigidity of the subunit interfaces of the trimeric glutamate transporter GltT during translocation. Journal of molecular biology, 372(3), 565–570. doi:10.1016/j.jmb.2007.06.067
Floyd, S., Favre, C., Lasorsa, F. M., Leahy, M., Trigiante, G., Stroebel, P., Marx, A., Loughran, G., O'Callaghan, K., Marobbio, C. M. T., Slotboom, D. J., Kunji, E. R. S., Palmieri,, F., & O'Connor, R. (2007). The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Molecular biology of the cell, 18(9), 3545–3555. doi:10.1091/mbc.E06-12-1109
Bamber, L., Harding, M., Monné, M., Slotboom, D. J., & Kunji, E. R. S. (2007a). The yeast mitochondrial ADP/ATP carrier functions as a monomer in mitochondrial membranes. Proceedings of the National Academy of Sciences of the United States of America, 104(26), 10830–10834. doi:10.1073/pnas.0703969104
Bamber, L., Slotboom, D. J., & Kunji, E. R. S. (2007b). Yeast mitochondrial ADP/ATP carriers are monomeric in detergents as demonstrated by differential affinity purification. Journal of molecular biology, 371(2), 388–395. doi:10.1016/j.jmb.2007.05.072
2006
Drew, D., Lerch, M., Kunji, E., Slotboom, D. J., & de Gier, J.-W. (2006). Optimization of membrane protein overexpression and purification using GFP fusions. Nature methods, 3(4), 303–313. doi:10.1038/nmeth0406-303
Ubbink-Kok, T., Nijland, J., Slotboom, D. J., & Lolkema, J. S. (2006). The ntp operon encoding the Na+ V-ATPase of the thermophile Caloramator fervidus. Archives of microbiology, 186(6), 513–517. doi:10.1007/s00203-006-0165-x
Burgess, C. M., Slotboom, D. J., Geertsma, E. R., Duurkens, R. H., Poolman, B., & van Sinderen, D. (2006). The riboflavin transporter RibU in Lactococcus lactis: molecular characterization of gene expression and the transport mechanism. Journal of bacteriology, 188(8), 2752–2760. doi:10.1128/JB.188.8.2752-2760.2006
2005
Chan, K. W., Slotboom, D. J., Cox, S., Embley, T. M., Fabre, O., van der Giezen, M., Harding, M., Horner, D. S., Kunji, E. R. S., León-Avila, G. & Tovar, J. (2005). A novel ADP/ATP transporter in the mitosome of the microaerophilic human parasite Entamoeba histolytica. Current biology : CB, 15(8), 737–742. doi:10.1016/j.cub.2005.02.068
Drew, D., Slotboom, D. J., Friso, G., Reda, T., Genevaux, P., Rapp, M., Meindl-Beinker, N. M., Lambert, W., Lerch, M., Daley, D. O., Van Wijk, K. J., Hirst, J., Kunji, E. R. S., & de Gier, J.-W. (2005). A scalable, GFP-based pipeline for membrane protein overexpression screening and purification. Protein science : a publication of the Protein Society, 14(8), 2011–2017. doi:10.1110/ps.051466205
Kunji, E. R. S., Chan, K. W., Slotboom, D. J., Floyd, S., O'Connor, R., & Monné, M. (2005). Eukaryotic membrane protein overproduction in Lactococcus lactis. Current opinion in biotechnology, 16(5), 546–551. doi:10.1016/j.copbio.2005.08.006
Monné, M., Chan, K. W., Slotboom, D. J., & Kunji, E. R. S. (2005). Functional expression of eukaryotic membrane proteins in Lactococcus lactis. Protein science : a publication of the Protein Society, 14(12), 3048–3056. doi:10.1110/ps.051689905
Lolkema, J. S., Sobczak, I., & Slotboom, D. J. (2005). Secondary transporters of the 2HCT family contain two homologous domains with inverted membrane topology and trans re-entrant loops. The FEBS journal, 272(9), 2334–2344. doi:10.1111/j.1742-4658.2005.04665.x
Lolkema, J. S., & Slotboom, D. J. (2005). Sequence and hydropathy profile analysis of two classes of secondary transporters. Molecular membrane biology, 22(3), 177–189. doi:10.1080/09687860500063324
2003
Lolkema, J. S., & Slotboom, D. J. (2003). Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis. Journal of molecular biology, 327(5), 901–909.
Kunji, E. R. S., Slotboom, D. J., & Poolman, B. (2003). Lactococcus lactis as host for overproduction of functional membrane proteins. Biochimica et biophysica acta, 1610(1), 97–108.
2002
van der Giezen, M., Slotboom, D. J., Horner, D. S., Dyal, P. L., Harding, M., Xue, G.-P., Embley, T. M., & Kunji, E. R. S. (2002). Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles. The EMBO journal, 21(4), 572–579.
2001
Slotboom, D. J., Konings, W. N., & Lolkema, J. S. (2001a). Cysteine-scanning mutagenesis reveals a highly amphipathic, pore-lining membrane-spanning helix in the glutamate transporter GltT. The Journal of biological chemistry, 276(14), 10775–10781. doi:10.1074/jbc.M011064200
Slotboom, D. J., Konings, W. N., & Lolkema, J. S. (2001b). Glutamate transporters combine transporter- and channel-like features. Trends in biochemical sciences, 26(9), 534–539.
Slotboom, D. J., Konings, W. N., & Lolkema, J. S. (2001c). The structure of glutamate transporters shows channel-like features. FEBS letters, 492(3), 183–186.
1999
Slotboom, D. J., Sobczak, I., Konings, W. N., & Lolkema, J. S. (1999a). A conserved serine-rich stretch in the glutamate transporter family forms a substrate-sensitive reentrant loop. Proceedings of the National Academy of Sciences of the United States of America, 96(25), 14282–14287.
Slotboom, D. J., Konings, W. N., & Lolkema, J. S. (1999b). Structural features of the glutamate transporter family. Microbiology and molecular biology reviews : MMBR, 63(2), 293–307.
1998
Lolkema, J. S., & Slotboom, D. J. (1998a). Estimation of structural similarity of membrane proteins by hydropathy profile alignment. Molecular membrane biology, 15(1), 33–42.
Lolkema, J. S., & Slotboom, D. J. (1998b). Hydropathy profile alignment: a tool to search for structural homologues of membrane proteins. FEMS microbiology reviews, 22(4), 305–322.
1996
Slotboom, D. J., Lolkema, J. S., & Konings, W. N. (1996). Membrane topology of the C-terminal half of the neuronal, glial, and bacterial glutamate transporter family. The Journal of biological chemistry, 271(49), 31317–31321.
Gaillard, I., Slotboom, D. J., Knol, J., Lolkema, J. S., & Konings, W. N. (1996). Purification and reconstitution of the glutamate carrier GltT of the thermophilic bacterium Bacillus stearothermophilus. Biochemistry, 35(19), 6150–6156. doi:10.1021/bi953005v
de Gier, J. W., Schepper, M., Reijnders, W. N., van Dyck, S. J., Slotboom, D. J., Warne, A., Saraste, M., Krab, K., Finel, M., Stouthamer, A. H., Van Spanning, R. J., & Van der Oost, J. (1996). Structural and functional analysis of aa3-type and cbb3-type cytochrome c oxidases of Paracoccus denitrificans reveals significant differences in proton-pump design. Molecular microbiology, 20(6), 1247–1260.
1995
van Spanning, R. J., De Boer, A. P., Slotboom, D. J., Reijnders, W. N., & Stouthamer, A. H. (1995). Isolation and characterization of a novel insertion sequence element, IS1248, in Paracoccus denitrificans. Plasmid, 34(1), 11–21. doi:10.1006/plas.1995.1029
van der Palen, C. J., Slotboom, D. J., Jongejan, L., Reijnders, W. N., Harms, N., Duine, J. A., & van Spanning, R. J. (1995). Mutational analysis of mau genes involved in methylamine metabolism in Paracoccus denitrificans. European journal of biochemistry / FEBS, 230(3), 860–871.
1994
van Spanning, R. J., van der Palen, C. J., Slotboom, D. J., Reijnders, W. N., Stouthamer, A. H., & Duine, J. A. (1994). Expression of the mau genes involved in methylamine metabolism in Paracoccus denitrificans is under control of a LysR-type transcriptional activator. European journal of biochemistry / FEBS, 226(1), 201–210.
de Gier, J. W., Lübben, M., Reijnders, W. N., Tipker, C. A., Slotboom, D. J., van Spanning, R. J., Stouthamer, A. H., & Van der Oost, J. (1994). The terminal oxidases of Paracoccus denitrificans. Molecular microbiology, 13(2), 183–196.
Swier, L.J.Y.M., Slotboom, D.J., and Poolman, B. (2016) In: ABC Transporters - 40 Years On
Guskov, A., and Slotboom, D.J. (2015) In: From Molecules to Living Organisms: An Interplay Between Biology and Physics
Poolman, B., and Slotboom, D.J. (2012) Substrate capture by ABC transporters. G.C.K. Roberts (ed.), Encyclopedia of Biophysics, DOI 10.1007/978-3-642-16712-6, Springer-Verlag Berlin Heidelberg 2012.
*Slotboom, D. J. (2013). Flipping the Sidedness of Disulfide Bond Formation. Journal of molecular biology 425(18), 3265-3267; doi:10.1016/j.jmb.2013.07.005
Poolman, B., Geertsma, E. R., & Slotboom, D. J. (2007). Biochemistry. A missing link in membrane protein evolution. Science (New York, N.Y.), 315(5816), 1229–1231. doi:10.1126/science.1140073
Poolman, B., Geertsma, E. & Slotboom, D-J. (2007). Controversy over EmrE structure - Response
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