TWO MANUSCRIPT NOTEBOOKS OF MEDICAL RESEARCH
books/ephemera, Connecticut / member Ephemera Society
GROUNDBREAKING NEUROSCIENCE RESEARCH
[NEUROSCIENCE RESEARCH NOTEBOOK] 1964-65 NEUROSCIENCE ORIGINAL RESEARCH by Dr. Leonard Malis (1919-2005), handwritten notes and drawings/graphs on many pages concerning Malis’s research involving irradiation in experiments on the brains of cats and rabbits, Malis’s research along with that of others led to irradiation as an important diagnostic procedure and also treatments for cancer and in blood transfusion; Dr. Malis’s research as seen in a limited respect in this notebook was extensive, involved, and meticulous; to put it simply here, it involved both the topography and circuitry of the brain with special interest in sensation and the pathways and interpretations of sensation by chemical and neural means with considerations relating to mental illness and mental health; Malis and his colleagues in research and medical practice were at the center of post-World War II, modern-day neuroscience advances; he is the author or co-author of numerous articles in scientific journals throughout his career; his name is nowhere in the notebook, his handwriting has been authenticated by matching with many references found online including his signature and also from the uniqueness of the content of this research notebook and Malis having done research at Brookhaven. ($3500.00)
DESCRIPTION AND GENERAL CONTENT OF RESEARCH NOTEBOOK: the book used as a notebook is a 7-1/2” x 12” ledger/register with lined pages, pages 9-111 (out of 300 total pages with pages 1-8 missing) have pencil and pen notes and some hand-drawn graphs mostly on right-hand pages but also a number of left hand pages for a total of 59 pages with notes varying from a few lines to complete pages and 4 pages with only headings including the number of a specific rabbit and no research notes but only a large “x” on the page, most of the research concerns cats; the format of the pages is date, animal and number, description, placement of instruments in animal’s brain, dosage of anesthesia and related time to take effect, deutrons (an isotope of hydrogen), the date the animal was "sacrificed" by perfusion.
EXAMPLES OF THE FORMAT: (A) Wednesday, May 26, 1965 / Cat #317 / Black, brown, grey, white / Shield edge 0.75 cm past coronal lesions to be at A.o / 70.1 counts / 123.8 secs / deuterons no filter 2.o na [na is a measurement of deutrons] / perfused 9-8-65; (B) 9-21-65 [#] 332 / Long haired black & white paws and muzzle / 3 kilo 1.5 cm .35 cc / to have double surface lesions made C - 17.5, (So at A-O0 / To fill in on prior series / Thru closed dura, lesions made c - 17.5 v at - 7.5 lesions at AO / 70.1 counts 140.3 secs / deuterons 2.o na chamber /// samples of notes from other pages are Lesion was left-sided in contrast to other animals...Brain removed and frozen in liquid nitrogen...Brain to Dr. Gerald Lehrer...Rabbit #5A Weighed 2.1 kilos...Brain was skwooshed during operative procedure - animal was sacrificed...presumably to get full thickness lesions of cortex, a total destruction, will have dura opened, teflon insert...Right side irradiation 103 secs, 70 counts...Left side irradiation 93.4 seconds, 70 counts...protons, no filter, 2.0 na chamber...Radiation as [cat] #302, Protons no filter...Radiated - 45 counts - 60.5 secs...Protons - 0.2 na chamber, Thru a 6 mm aperture in close filter rach. No shield on animal. Teflon dural substitute...lesion irrad. posterior to this area...3/17/65 Mount Sinai Hosp[ital]...Dura opened as cruciate on each calendered teflon artificial dura washed free of powder...For next group of cats, 311, 312, 313, 314, apertures were made as follows [with diagram underneath] all cats in this group get deuterons... Sacrifice date for anatomical study...Died at Brookhaven before irradiation...Cats for following series to have left lobectomy for medial surface right irradiation...taken to Brookhaven despite partial wound ruptures...End of September run at Brookhaven...";
CONTENT RELATING TO ‘PASIK MONKEYS’: page 45 is headed “For Pasik Monkeys – calculation”, with the following pages 46 and 47 having notes relating to this topic, page 47 has the heading “Pasik Monkeys Dec. 14, 1964”, Malis’s notes and graphs on pages 45 and 46 are like his notes on the cats and rabbits, page 47 has columns which are presumably dosages, Pedro and Tuaba Pasik were noted researchers active in the New York city area and elsewhere where leading neuroscience research was taking place, like Malis, they were associated with Mt. Sinai Hospital, but the Pasiks and Malis also had many friends and colleagues in common and conducted research at the same locations;
PHOTOGRAPHS LAID IN: nine/9 black-and-white photographs of the brains of rabbits [?] probably for an article by Malis and associates based on the research recorded in the notebook – the photographs were laid in in the notebook when the seller purchased it, the seller was told that they were rabbits’ brains, and content of the notebook is on research using rabbits (as well as cats), 8 of the 9 black-and-white photographs are 10” x 8” on stiff photographic paper with one reduced to 7” x 4-3/4” and pasted to a white sheet of paper with pasted slips with notes underneath it presumably directions for placement in a medical journal article;
MISCELLANEOUS NOTES LAID IN: four note sheets with Santa Inez Inn, Pacific Palisades [California] letterhead, on the back sides of the pages numbered 3, 4, 6, 7 are notes by Malis presumably in relation to some conference or symposium he attended in California at some time, the handwritten notes include names with phrases and figures beneath these apparently taken from articles in scientific journals and also notes that are apparently Malis’s own thoughts or references, these notes are included since they were found laid in in this notebook although the relationship between them and the content of the notebook, if any, is not evident, during Malis’s career universities and laboratories in California were engaged in research and interests along the lines of his in the New York city area;
MISCELLANEOUS CONTENT OF NOTEBOOK: on the next to last page (299) is a list of 11 items “Left at Brookhaven , December 16, 1964” which includes Nembutal, Gloves 6 size (8 pr), Cat Ident a [identification] band, Bone Wax, Merculene, and Sterile Towels; below this list, the last entry in the notebook, in red pen is “We need cat food, milk and saline for next trip.; page 113 is headed "Messages - 3/20/72" with this page and following pages thru 123 mostly on the right-hand pages only appearing to be a typical phone log with names and phone number and with some a brief note, this section is not in Dr. Malis’s handwriting;
DOCTOR LEONARD MALIS: DR. LEONARD MALIS (1919-2005) was a leading, influential, and historically important doctor and researcher in the field of neuroscience and brain study, psychiatry, and psychology throughout his career, he was also noted for his innovations and inventions regarding surgery, his Sept. 16, 2005 obituary in the N. Y. Times notes, “When the definitive history of neurosurgery is written, a significant portion will be devoted to the contributions of Leonard I. Malis…Dr. Malis was a pioneer in microneurosurgery, introducing the operating microscope to neurosurgery in New York…His clinical and academic legacy will enrich the practice of neurosurgery for generations to come…”; in the 1950s he was Dazian Fellow in neurophysiology under Yale’s legendary at John Fulton, abundant material on Malis’s biography, career, and contributions can be found online;
CONDITION OF NOTEBOOK: well-preserved with all notes legible in Dr. Leonard Malis’s fairly large, neat, orderly handwriting for these notes kept as references and guides for himself and for colleagues in the groundbreaking neuroscience research and presumably for historical interest as well.
WWII NORTH AFRICA ALLIED TYPHUS COMMISSION STUDY
[1943 NORTH AFRICA TYPHUS COMMISSION STUDY; U. S. MILITARY WWII] 1943 WWII United States of America/U. S. Armed Services TYPHUS COMMISSION report/study of many typescript pages with some handwritten editing in a looseleaf binder, 48 pages (numbers at bottom left corners of some pages, but these are not sequential as pages have been inserted and numbers of some pages have been changed), 6” x 9-1/2” including foldouts mostly charts, with six pages of handwritten notes laid in; AUTHOR/COMPILER OF NOTEBOOK: the material is identified as relating to the WWII USA Typhus Commission in North Africa by the signature/autograph of “W. B. McAllister” on the reverse of one of the loose sheets with a chart on the other side as well as by its content, McAllister’s signature is written in ink twice with the two next to each other, handwriting on the loose pages and also scattered handwritten editing and notes on the bound pages of the notebook resembles the handwriting of the McAllister signatures, printed edits and notes are assumed to be his as well, online research identifies McAllister as a doctor serving in the U.S. Navy Medical Corps Reserve from 1941-46, “Part of that time he was executive office of the U. S. Typhus Commission in Cairo” (google reference, Reading Eagle newspaper, Feb. 27, 1955), after wartime service, he was on the faculty of the Yale University Medical School, no signature or other handwriting of McAllister has been located for 100% confirmation, but all evidence from the notebook along with research on McAllister and other names and material from the notebook leads to this conclusion; an additional reference in the notebook supporting its connection to Wm. B. McAllister and the WWII US Typhus Commission is a handwritten note on the back of one page, “Order Home - Specify travel by military aircraft only [underlined twice] - Air Priority #2 - Letter from General Fox justifying trip”, another note “Genl. Fox - Apr. 30 (12)” [number in parentheses presumably referring to cases], Brigadier General Leon A. Fox was the Typhus Commission’s head for a time, and McAllister undoubtedly worked with him; NOTEBOOK CONTENT: the focus of the report/study is typhus in Algeria and Morocco with some references to typhus in other parts of the world with interviews with doctors including French doctors, most associated with the Pasteur Institute treating patients and collecting data while also working on a cure for typhus especially for Allied troops in North Africa and also prisoners-of-war and local populations, the pages are neatly-typed and formatted pages of statistics on typhus particularly in areas and towns of Algeria and Morocco and also single-spaced pages of interviews with doctors or excerpts from works by them; as noted by headings to some pages, some material has been taken from published volumes of compiled data (e. g., U.S. Public Health Service, League of Nations Report), while other content is original from French doctors in their studies as indicated by references and notes and members of the US Typhus Commission; some content of the notebook relates to the Nobel Prize nominee Theodore E. Woodward identified in a number of places as "Woodward" including sections titled “Woodward Vaccine Experiments” a little longer than one page and another page-and-a-half section titled “Woodward's Description of His Typhus Trips,” a member of the Typhus Commission working in North Africa, in 1948 Woodward was nominated for the Nobel Prize for Medicine for his work regarding typhus and typhoid fever; the chart on one page is headed “Cases and Deaths from Typhus Fever, U.S.P.H.S. (Public Health Service)” and another is headed “Notes on Report of the 1941-1942 Typhus Epidemic in Algeria submitted by Dr. G. Grenoilleau,” headings of a few other pages are “Regional Incidence of Typhus Fever during Epidemic Years and 1939 to 1943 - Morocco,” “Statistics of Typhus Cases Hospitalized at El Kettar (Algeria). 1943. Reported by Dr. Lemaire. To Col. Plotz,” [Dr. Harry Plotz, an important doctor in the discovery of the causes and development of the treatment of typhus, the “Plotz bacillus” is named after him], “Woodward Vaccine Experiments,” “Interview with Dr. Gaud” [Commission for Health in Morocco]; - examples of other headings, notes, etc., of the varying material all relating to the typhus studies are: “extracted from the report of the prison Doctor - courtesy Sergeant”; “Method of Making Lung Typhus Vaccine - Inst. Pasteur, Alger, Horrenberger & Renoux (from mouse lungs)”; “Figures given are taken from graphs made by Dr. Sergent…"; “Notes on Report of the 1941-42 Typhus Epidemic in Algeria submitted by Dr. G. Grenoilleau” [6 pages]; “from Woodward” [handwritten note]; “Woodward Vaccine Experiments”; “American Typhus ??? Cases names, symptoms, and British 61st Station Hospital”; information on practically every doctor named in the report can be found in online research with varying search words of the name, typhus, North Africa, Pasteur Institute, the doctors succeeded in finding a cure for typhus, the varied content of this notebook collects the background and the basis for this cure; CONDITION: well-preserved, a few pages partly separated from rings of binder. all text legible though some light, handwritten parts are legible.