Blood-Brain Barrier

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells; that prevents solutes in the circulating blood from non-selectively crossing into the extracellular fluid;

Schematic of semipermeable membrane during hemodialysis, where blood is red, dialysing fluid is blue, and the membrane is yellow.

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Extracellular fluid;

The distribution of the total body water in mammals between the intracellular compartment and the extracellular compartment, which is, in turn, subdivided into interstitial fluid and smaller components, such as the blood plasma, the cerebrospinal and lymph fluid

of the central nervous system where neurons reside. The blood–brain barrier is formed by endothelial cells of the capillary wall, astrocyte end-feet ensheathing the capillary, and pericytes embedded in the capillary basement membrane.  This allows the passage of some small molecules by passive diffusion, as well as the selective and active transport of various nutrients, ions, organic anions, and macromolecules such as glucose and amino acids that are crucial to neural function.

We hope the above brief on;

Blood-Brain Barrier

was of help.

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