Curriculum

M2 Microfluidique


General Organization        2

Schedule, updated informations and numerical workspace        2

Important dates        2

Remarks on the Short-term Research Project        2

Remarks on the Long-term Research Project        3

Course descriptions        3

UE Microfluidics and Microfabrication (6 ECTS)        3

Micro-hydrodynamics        3

Microfabrication        4

UE Biology (3 ECTS)        4

Introduction to biology        4

A biophysicist view on cells and bacteria        4

Introduction to cell migration and immunology        4

Model organisms in biology        4

UE Phenomena at the meso-scale (12 ECTS)        5

Soft Matter and Interfaces : Capillary and wetting phenomena        5

Rheology        5

Chemistry of functional surfaces        5

UE Lab on a Chip (6 ECTS)        6

Analytical chemistry        6

Flow chemistry        6

Organ on chip        6

UE Semaine PSL        6

Administrative contacts        6


  1. General Organization

The Microfluidics degree (Master 2), associated to the Institut Pierre-Gilles de Gennes,  is an interdisciplinary degree, oriented towards innovation and industrial applications. In a few words the shortest way to take part to the start-up ecosystem in the microfluidics domain.

The degree is part of

  1. the « Physics of Complex System » Master’s degree  (Sorbonne Université, Université Paris-Diderot et Université Paris Saclay) for physicist students
  2. the « Materials Science and Engineering » (Université PSL) Master’s degree for chemists and biologists.

The Microfluidics degree is committed to deliver a high-level technological training to the students, that will be achieved through a set of lab classes taking place on the technological platform of IPGG, the conduction of a Master’s project and ultimately culminating in a Master’s thesis.

The overall content of the Microfluidics degree is equal to 60 ECTS, from beginning of september to the end or june or july.

  1. Schedule, updated informations and numerical workspace

The up-to-date schedule can be viewed here (pwd : ipggipgg):  

https://microfluidics-master.fr/schedule/

A shared directory for the pdf documents shared by the instructors will soon be created. More details to come.

  1. Important dates

Monday 9th of September: courses start; mandatory presentation of 2 hour to explain rules and answer your questions.

Week of the 19th of October, 2019: Fall Holidays

Thursday 19 of December, 2019 : Christmas party

January 2020 : Exams

Monday 3d of February, 2020 : Start of the Long-term research internship

  1. Remarks on the Short-term Research Project

The short-term research project objectives are twofold :

More information on the projects will be communicated in September. To consult the rules applied so far (may be updated):

At the end of the first semester, students are expected to produce a written report on these two aspects of the research project, and present their work in front of a jury.

A summary of important rules:

- The Short-term Research Project has to be done in an academic laboratory member of the Institut Pierre-Gilles de Gennes or a team of one of the instructors of the M2 Microfluidics. For the list of the laboratories associated to IPGG : http://www.institut-pgg.com.

- Start-ups or research centers in private companies are not allowed. A project can be done in an academic laboratory in collaboration with a start-up or a private company.

- Projects start at the end of September and have to be conducted during the time slots empty of any lectures, lab class or any mandatory event.

  1. Remarks on the Long-term Research Project

A summary of important rules:

- The Long-term Research Project can be done in an academic laboratory, a start-up or research centers in private companies. In these two latter cases, the content of the internship has to be validated by the M2 coordinator (J. Fattaccioli).

 

- A project can be done in an academic laboratory in collaboration with a start-up or a private company.

- Projects start at the beginning of February and should last at least 5 months (full time).

- Depending on the university where the students are administratively enrolled, the procedure related to the “convention de stage” (internship agreement) can vary. Please ask for details well in advance (December…) to be sure that no delay will forbid you to start your internship.

  1. Course descriptions

  1. UE Microfluidics and Microfabrication (6 ECTS)

Micro-hydrodynamics

Course Instructor(s): MC Jullien, N. Brémond, P. Tabeling

Lectures : 27h

  1. Navier-Stokes equation
  2. Low-Reynolds number hydrodynamics
  3. Modes of transport (diffusion, convection, electro-osmosis)
  4. Hydrodynamics phenomena at intermediate Reynolds numbers in microsystems (ex. Dean flows)
  5. Interfacial hydrodynamics and formulation
  6. Paper Microfluidics

Microfabrication

Course Instructor(s): J. Fattaccioli, M. Morel, B. Le Pioufle, M. Zhang, A. Colin, Y. Chen

Lectures : 19h, Lab classes : 15h

  1. Basics of silicon microfabrication : lithography, etching, thin-film deposition, mask alignments, etc.
  2. PDMS and NOA microfabrication
  3. Bio-MEMS : interfacing silicon with biology
  4. Flexible electronics
  5. Nanofabrication : E-beam lithography, nano-imprint

  1. UE Biology (3 ECTS)

Introduction to biology

Course Instructor(s): L. Tricoire

Lectures : 12h

  1. DNA structure and genetic basis of heredity
  2. Gene expression (RNA structure and transcription)
  3. Protein translation and structure
  4. Conventional methods for DNA, RNA and protein analysis.
  5. Microfluidic methods for genome, transcriptome and proteome studies
  6. Gene editing methods.

A biophysicist view on cells and bacteria

Course Instructor(s): P. Silberzan

Lecture(s) : 6h

  1. Cell monolayers.
  2. Microswimmers and chemotactism
  3. Collective behavior of bacteria and cells

Introduction to cell migration and immunology

Course Instructor(s): M. Piel, P. Vargas

Lectures : 6h

  1. Introduction to the immune system and its cellular and systemic players
  2. Use of microfabricated systems to address questions related to cell migration in confined spaces

Model organisms in biology

Course Instructor(s): W. Keil

Lectures : 3h

Overview of the most common model organism, why we use them, and why people use a specific one as compared to the others.

  1. UE Phenomena at the meso-scale (12 ECTS)

Soft Matter and Interfaces : Capillary and wetting phenomena

Course Instructor(s): D. Quéré, L. Bocquet

Lectures : 28h (D. Quéré) and 28h (L. Bocquet, for PCS students only)

In this course, we will introduce the key concepts of soft matter, seen from the perspective of its interfaces.

We will place particular emphasis on the role of soft material interfaces (they are, for example, the ones that "harden" shaving foam), starting from the definition of an energy of an interface and exploring some of its countless consequences. The course will thus introduce the elementary concepts of soft matter and its interfaces - adsorption, wetting, entropic forces, osmosis,...-, as well as the toolbox that allows us to describe it, coupling physics of continuous environments (capillarity, wetting, hydrodynamics, elasticity, electrodynamics of interfaces,...) and statistical physics (phase transitions, fluctuations, Langevin equation,...). The objective is to give a panorama of soft matter from macroscopic properties to its microscopic foundations.

This teaching will be based on a number of key experiences, and we will often use scaling laws approach to analyze them.

Rheology

Course Instructor(s): A. Lindner

Lectures : 21h – Lab class : 12h

  1. Classic and microfluidic rheometry for simple and complex fluids
  2. Non-Newtonian properties (rheofluidification, normal stresses, viscoelasticity, flow threshold)
  3. Typical complex fluids: polymer solutions, biological fluids, suspensions, active fluids, gels

Single molecule approaches for dynamics and super-resolution imaging in biological systems

Course Instructor(s): B. Hajj

Lectures : 9h

  1. Basic concepts in photonic microscopy (brightfield, fluorescence)
  2. Fluorescence markers
  3. Consideration for single molecule detection
  4. Single molecule imaging tracking
  5. Super-resolution microscopy

Chemistry of functional surfaces

Course Instructor(s): M. Tatoulian, J. Fattaccioli

Lectures(s) : 10h

  1. Functional surfaces : hydrophobicity and hydrophilicity, chemical functionalization
  2. Plasma and CVD-based methods for surface modification (PDMS, PS, glass, etc)
  3. Wet methods for surface functionalization

  1. UE Lab on a Chip (6 ECTS)

Analytical chemistry

Course Instructor(s): F. d’Orlye, S. Descroix, J. Baudry

  1. Miniaturization for analytical chemistry
  2. Physical aspects of immunoassays
  3. Immunoassays : from basic to advanced setups

Flow chemistry

Course Instructor(s): M. Tatoulian, M. Zhang

Lecture(s) : 9h, Labclass : 3h

  1. Mass and thermal transfers at the milli-fluidic scale
  2. Milli-flluidic reactors design
  3. Industrial examples of synthesis made by flow chemistry

Organ on chip

Course Instructor(s): S. Descroix, C. Villard, Y. Chen, C. Aimé

Lecture(s) : 22h

  1. Collagen and extracellular matrix properties
  2. Why using OoC as organ models for pharmacology or basic science ?
  3. Plant and fungi on chip
  4. OoC in neuroscience
  5. Some examples : Intestine, heart and lung-on-chip

  1. UE Semaine PSL

For students enrolled in the M2 Sciences et Genie des Matériaux.

Students of the Physics of Complex Systems M2 are expected to work on their Short-Term Research project.

  1. Administrative contacts

If you have any question related to administrative issues (enrollment, internship contracts, etc), please send an email to the following people, with J. Fattaccioli’s email address in cc (m2microfluidique@gmail.com):

PCS - Sorbonne Université :

Dominique Mouhanna : Dominique.mouhanna@sorbonne-universite.fr

Secretary : Corinne SALLANDRE : Corinne.sallandre@sorbonne-universite.fr

PCS - Université Paris Saclay

Emmanuel Trizac : emmanuel.trizac@u-psud.fr:

PCS - Université Paris Diderot

Jean-Baptiste Fournier : jean-baptiste.fournier@univ-paris-diderot.fr

SGM – Paris Sciences Lettres

Cécilie Duhamel : cecilie.duhamel@mines-paristech.fr

Secretary : Pascale Baverel : pascale.baverel@chimiparistech.psl.eu