Topics

1. Introduction of the course and cancer biology
2. Overview of computational problems for analyzing mutations in cancer
3. Deep dives on three key problems

1. Signatures of mutational process acting on cancer genomes
2. Identifying the mutations that drive cancer
3. Predicting genetic interactions between pairs of genes

Papers

Blei (Communications of the ACM, 2012)

Alexandrov, et al. (Cell Reports & Nature, 2013)

Vandin, et al. (Genome Research, 2012)

Yu, et al. (Cell Systems, 2016)

Shiraishi, et al. (PLoS Genetics, 2015)

Huang, et al. (Bioinformatics, 2017)

Tan & Fevotte (IEEE Transactions PAMI, 2013)

Kasar, et al. (Nature Communications, 2015)

Kim, et al. (Nature Genetics, 2016)

Constaninescu, et al. (Bioinformatics, 2016)

Kim, et al. (Nature Biotech, 2016)

Vandin, et al. (Journal of Computational Biology, 2011)

Benson, et al. (Science, 2016)

Jacunski, et al. (PLoS Comp Bio, 2015)

Cho, et al. (Cell Systems, 2016)