Link to this document:
https://docs.google.com/document/d/1s_A4pWckfvvfEe7QjVo8BX2O8EAE8fZwDXSJ36TDCIs/edit?usp=drivesdk
Scientific Information:
https://linksharing.samsungcloud.com/fOCrsQwJpLHJ
Information on Fulvic:
-FULVIC & HUMIC SCIENTIFIC STUDIES-
Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes:
Or:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151376/
Humic Acid & Viruses; Review of Humic Acid May 2016:
Humic acid interference with virus recovery by electropositive microporous filters:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC203572/
Viruses: Nutritional Support for Immunity Against Viruses Including the Coronavirus:
In vitro anti-influenza virus activity:
https://pubmed.ncbi.nlm.nih.gov/11890523/
The Real Story about Humic Acid:
Did you know that Humic Acids functions both prophylactically as well as therapeutically in the treatment of viral diseases?
Soil humic substances hinder the propagation of prions:
https://ui.adsabs.harvard.edu/abs/2013EGUGA..15.1178L/abstract
Take some BOO & knock out the spike protein’s game plan!!
Interaction of Drug Candidates with Various SARS-CoV-2 Receptors: An in Silico Study to Combat COVID-19:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7640951/
Cancer:
http://www.thehelix12project.org/fulvic-acid--cancer---important.html
https://fulvic.info/fulvic-acid-cancer/
Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691117/
Antitumor effect of humus extract:
https://pubmed.ncbi.nlm.nih.gov/17984596/
Fulvic acid promotes extracellular anti-cancer mediators from RAW 264.7 cells, causing to cancer cell death in vitro:
https://www.sciencedirect.com/science/article/pii/S1567576916301734
Effects of Fulvic Acid on Different Cancer Cell Lines:
Anti-Proliferative and Anticancer Properties of Fulvic Acid on Hepatic Cancer Cells:
https://www.jcehepatology.com/article/S0973-6883(15)00118-8/fulltext
Fulvic / Humic Acid - Cancer & Diseases (Heart disease, Insulin Resistance/Diabetes, Autoimmune Diseases (Rheumatoid Arthritis, Lupus, Fibromyalgia)
https://www.doctorsbeyondmedicine.com/listing/fulvic-humic-acid-cancer-diseases
Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease:
https://pubmed.ncbi.nlm.nih.gov/21785188/
The Antiinflammatory Properties of Humic Substances: A Mini Review-
https://pubmed.ncbi.nlm.nih.gov/25732236/
Fulvic Acid -A Natural and Multifaceted Approach to the Management of Inflammatory Dermatosis:
Observational Study-
Impact of humic acids on the colonic microbiome in healthy volunteers:
https://pubmed.ncbi.nlm.nih.gov/28223733/
Inhibition of HIV-1 in cell culture:
https://pubmed.ncbi.nlm.nih.gov/8610466/
Active Antiseptic Agent Against Candida albicans Biofilms:
https://pubmed.ncbi.nlm.nih.gov/22479260/
https://linksharing.samsungcloud.com/tcmz4DLB6ejd
Renoprotective Effect of Humic Acid on Renal Ischemia-Reperfusion Injury: An Experimental Study in Rats:
https://pubmed.ncbi.nlm.nih.gov/25985848/
An Unnatural Epidemic: Kidney Disease Caused by Glyphosate:
https://www.gmosrevealed.com/an-unnatural-epidemic-kidney-disease-caused-by-glyphosate/
Humic Acid, Neutralizing Effects on Glyphosate (Glyphosate linked to mysterious kidney disease):
https://www.bioag.eu/en/glyphosate-and-the-neutralizing-effect-of-humic-acid/
https://naturalrelieved.com/corona-virus-and-fulvic-acid
Fulvic acid inhibits aggregation and promotes disassembly of tau fibrils associated with Alzheimer's disease:
https://pubmed.ncbi.nlm.nih.gov/21785188/
A toxicological evaluation of a fulvic and humic acids preparation:
https://www.sciencedirect.com/science/article/pii/S2214750020303929
The Effect of Humic Acid Substances on the Thyroid Function and Structure in Lead Poisoning:
https://www.scielo.br/j/rbca/a/4t3RkVws3rnytXk8S8g97hJ/?lang=en
Fulvic Acid- Thyroid:
https://fulvic.info/fulvic-acid-thyroid/
Effect of Humic Acid on Oxidative Stress and Neuroprotection in Traumatic Spinal Cord Injury: An Experimental Study:
Fulvic and humic acid are incredible heavy metal chelators, and help to reduce toxic heavy metal load in the body.
https://www.osti.gov/etdeweb/biblio/175014
Studies Conducted with Fulvic and Humic Acids.
Over 50% of hospital patients noticed that they were able to sleep more relaxed when
treated with fulvic acid, a humic extract. Improved sleep came as an added benefit since the patients were already being treated with the fulvic acid for various chronic diseases.
Bingwen Su, Jiangxi Humic Acid, 3 (1985), as in: Application of Fulvic acid and its derivatives in the fields of agriculture
and medicine; First Edition. June 1993; IHSS, Sevilla, Spain.
Hospital studies have shown that patients with normally incurable epidemic Hemorrhagic Fever were able to be successfully treated with humic extracts, which stopped bleeding, restored circulation, removed clots, was anti-viral, and significantly bolstered and regulated
the immune system. Yinzhang Cui, Humic Acid, as in: Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition. June 1993; IHSS, Sevilla, Spain.
Extensive hospital eye clinic studies using humic extracts showed 100% success in curing eye diseases caused by virus, bacteria, or fungus, also healing ulcerous wounds, relieving inflammation, and stopping hemorrhaging, without side effects.
Guofan, Tang, Jiangxi Humic Acid, 3 (1984), as in: Application of Fulvic acid and its derivatives in the fields of agriculture
and medicine; First Edition. June 1993; IHSS, Sevilla, Spain.
Remarkable bone regeneration and resorption characteristics were identified when the animal bone implants were impregnated with a low molecular weight humic substance (fulvic acid) prior to transplant in to patients. The bone implant then became highly osteoconductive, and
served the host tissue as a “guide-line” for the deposition of newly developing bone tissue. The same transplant procedure without the fulvic acid showed no signs of regeneration during the course of the experiment.
While on the lookout for a new group of active agents with the ability to promote wound healing, the doctors came across the humic substances. The doctors said that the bone resorption is most easily explained by the known ability of humate to induce the activation of leucocytes. They said that previous experiments had established that the humic substances are able to bind to calcium-containing compounds, stimulate granulocytes, and block the infectivity of the
HIV virus.
Extracts From:
"Medical Aspects and Applications of Humic Substances" Regarding the Antiviral Activity of Humic Substances Prof. Dr. Renate Klocking & Dr. rer. nat. Bjorn Helbig
Institute for Antiviral Chemotherapy,
Friedrich Schiller University,
Jena, Germany
MULTIPLE VIRUSES INHIBITED
"Preliminary in-vitro studies with Coxsackie A9 virus, influenza A virus and herpes simplex virus type 1 (HSV-1) have already shown that (Humic Substances) are effective against both naked and enveloped DNA viruses (Klocking and Sprosig, 1972, 1975; Thiel et al., 1977)."
"Further investigations corroborate the ability of (Humic/Fulvic Acid) to inhibit selectively
viruses for human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2),
cytomegalovirus (CMV) and vaccinia virus (Schols et al., 1991; Neyts et al., 1992)."
VIRAL FUSION INHIBITION
"With most viruses, the inhibitory effect of (Humic/Fulvic Acid) is directed specifically against an early stage of virus replication, namely virus attachment to cells (Klocking and Sprosig, 1975; Schols et al., 1991; Neyts et al., 1992)." "…it appears likely that the poly-anionic Humic/Fulvic Acids occupy positively charged domains of the viral envelope glycoprotein’s, which are necessary for virus attachment to the cell surface (Neyts et al., 1992)."
HERPES
"The effect of (Humic/Fulvic Acids) on an early stage of herpes virus replication has been confirmed by the results of animal experiments. The number of lesions in the cornea of HSV-1-infected rabbits was strongly reduced when a solution of the (Humic/Fulvic Acid) was applied into the conjunctival sac of the eye along with or immediately after the infectious agent." "Current interest is directed to the prophylactic effect of (Humic/Fulvic Acids) on
recurrent HSV infection."
"It is known that topical application of (Humic/Fulvic Acid) may
significantly reduce or even completely suppress experimentally induced herpes in the mouse ear (Durre and Schindler, 1992), though the mechanistic basis of this effect remains to be elucidated."
HIV
"A low-molecular weight (Humic/Fulvic Acid) (HS 1500, M.W. = 1500 Daltons), was found to strongly inhibit HIV-1 in vitro (Schneider et al., 1996)."
NON-IRRITATING
"Studies on the mechanism of action revealed virus penetration into host cells as the target of the anti-HIV-1activity. (Humic/Fulvic Acid) has passed a panel of pre-clinical tests including eye irritation according to Draize, as well as pregnancy risk in rats. Neither sensitizing nor irritating effects were detectable in concentrations of up to 10% HA/FA
(Wiegleb et al., 1993; Lange et al., 1996a,b).'
CONCLUSION
"Taken together, results so far show that Humic Substances are promising candidates for prophylactic rather than therapeutic use in the treatment of viral diseases."
Editor's Note: This last conclusion is based only on the limited studies referred to above.
These studies show that Humic/Fulvic Acid is first a preventative, because it interferes with a virus' ability to attach to a host cell,
penetrate the host cell, and reproduce itself.
Scientific studies have demonstrated that if a host cell is penetrated before the introduction
of the Humic/Fulvic Acid, the reproductive process is not halted. HOWEVER, after the virus reproduces, the host cell releases the new viruses into the bloodstream. At this point, if Humic/Fulvic Acid is present, it can prevent the new generation(s) of viruses from attaching to additional host cells. This is a therapeutic action that the above research has not specifically verified in procedure, hence the above conclusion. Further, the interaction of Humic/Fulvic Acid regarding the aforementioned viral studies would also be presumed to work for most if not all viral diseases. Other studies are currently on going throughout the world.
FULVIC/HUMIC ACID REFERENCES ON HUMAN/ANIMAL STUDIES (with on-
line documentation in English):
1. Humic substances, especially low-molecular weight humic substances [fulvic acids], increase respiration in (rat liver) mitochondria.
Study Conclusions Summary: Fulvic and humic acids stimulated respiration in rat liver
mitochondria. The humic materials lower in molecular weight--(in other words, the
humic material most closely resembling/most likely identifiable as fulvic acids, rather
than as humic acids) induced more stimulation for mitochondrial respiration.
[See abstract at: http://www.ncbi.nlm.nih.gov/pubmed/2953069 for more details.]
Reference Information:
Effect of humic substances on mitochondrial respiration and oxidative phosphorylation.
Visser SA. Sci Total Environ. 1987 Apr;62:347-54. PMID: 2953069 [PubMed - indexed for MEDLINE]
2. Humic substance supplementation through drinking water benefits live performance, feed
efficiency and meat color in broilers (chickens).
This study from agricultural departments in a Turkish University examines different
amounts of humic substance (including but not limited to fulvic substances)
supplemented to chicken intake. Conclusions state that 300ppm and 450ppm appear to
improve feed efficiency and lightness in color of breast and thigh meat, respectively.
[See abstract at: http://www.ncbi.nlm.nih.gov/pubmed/19175461 for more details.]
Reference Information:
Effects of humic substances supplementation provided through drinking water on performance,
carcass traits and meat quality of broilers.
Ozturk E, Ocak N, Coskun I, Turhan S, Erener G.
Journal of Animal Physiology and Animal Nutrition (Berl) 94.1: 2009 Jan 13, p78(8).
PMID: 19175461 [PubMed - as supplied by publisher]
3. “Effects of a dietary complex of humic and fulvic acids ... on the health and production of feedlot
cattle...”
Cattle fed with a humic and fulvic acid complex reached market specifications for
body weight and fat depth in fewer mean days, had a greater average daily gain and a
lower feed conversion ratio (as well as whiter fat), compared to cattle in the control, or
humic/fulvic acid-less group of cattle.
[See abstract at: http://www.ncbi.nlm.nih.gov/pubmed/18271826 for more details.]
Reference Information:
Effects of a dietary complex of humic and fulvic acids (FeedMAX 15) on the health and production of feedlot cattle
destined for the Australian domestic market.
Cusack PM.
Aust Vet J. 2008 Jan-Feb;86(1-2):46-9.
PMID: 18271826 [PubMed - indexed for MEDLINE]
4. “Genetic diversity-independent neutralization of [various viruses]... by enveloped virus
neutralizing compounds (EVNCs)”, including fulvic acids (in addition to other agents from
pomegranate juice).
This report outlines research previously completed on the ability of fulvic acids that
(can be described as Envelope Virus Neutralizing Compounds because they) can
render vaccinia virus, HIV and SARS virus non-infectious, in addition to other
research that has demonstrated fulvic acid's ability to inactivate genetically diverse
strains of influenza, including H5N1.
[See abstract at: www.ncbi.nlm.nih.gov/pubmed/18241960 for more details]
Reference Information:
Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of
influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus
neutralizing compounds (EVNCs).
Kotwal GJ.
Vaccine. 2008 Jun 6;26(24):3055-8. Epub 2007 Dec 26.
PMID: 18241960 [PubMed - indexed for MEDLINE]
5. “Certain humic substances may have possibilities to improve growth performance and reduce
ammonia emission” via swine diet supplementation.
Previous reports on ammonia emission reduction resulting from direct applications of humic and fulvic acids to livestock manure are mentioned in this article, in addition to
complete disclosure of a measurements from a U.S.-based study in which swine diets
were supplemented with various amounts of humic substances for this same purpose
and for purposes related to the general benefits of fulvic/humic acid supplementation.
Reference Information:
Humic substances may improve pig growth.
Goihl J.
Journal of Animal Science Vol. 84, No. 9.
Miller Publishing Co. Inc. 2006.
6. Fulvic acid assists patients in healing mucous membrane bleeding.
“Six patients suffering from mucous membrane bleeding all showed apparent positive
results...No relapse was observed in any case...It is clear that fulvic acid indeed can
[help] stop bleeding...Experimental results indicated that 30 minutes following
intravenous injection of dogs with 160 mg of fulvic acid...The blood clotting process
was accelerated, yielding advantageous blood coagulation.
Reference Information:
Observations on the use of fulvic acid as a blood coagulant.
Suchen Cao, Medical University in Zhejiang Province [Jiangxi], China
Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; Chapter 35; First Edition: June
1993; IHSS: Sevilla, Spain.
7. In vitro proof in topical treatment of pyotraumatic dermatitis in cats and dogs with a ('sister-form')
of fulvic acid that was simultaneously studied for its ability to counter the following “microbial
pathogens...Streptococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia
coli, Streptococcus pyogenes, Klebsiella pneumoniae, Proteus mirabilis and Candida albicans”
Plans by one company to produce a topical/oral application that combines fulvic acid
with a few additional ingredients have proven that fulvic acid-containing product's can
improve pyotraumatic dermatitis in dogs and cats is currently undergoing an
international patent process for the product, also stating that the 'pharmaceutical
composition' may be used to treat 'a condition in a human or an animal'.
Reference Information:
Fulvic acid and its use in the treatment of various conditions.
Dekker J, Medlen CE
Patent Corporation Treaty number IB1999/001649
and
An in vitro investigation of the antimicrobial activity of oxifulvic acid.
Van Rensburg CEJ, Van Straten A, Dekker J
Journal of Antimicrobial Chemotherapy, 2000; The British Society for Antimicrobial Chemotherapy
8. Dog kidney cells are administered influenza virus and humic acids, resulting in the inhibition of viral
replication.
"...Humic Acid inhibit[s] the in-vitro replication of influenza virus A/WSN/33 (H1N1)
in Madin-Darby canine kidney (MDCK) cells at concentrations of no cytotoxicity...
The IC50 for Humic Acid was 48.61 +/- 7.32 microg/ml and 55.27 +/- 5.46 microg/ml
respectively when the compound was added at the stage of viral adsorption or post-
adsorption... Humic acid inhibits the endonuclease activity of viral RNA polymerase."
[See abstract at: www.ncbi.nlm.nih.gov/pubmed/11890523 for more details]
Reference Information:
In vitro anti-influenza virus activity of synthetic humate analogues derived
from protocatechuic acid.
Lu FJ, Tseng SN, Li ML, Shih SR.
Archives of Virology. 2002;147(2):273-84.
PMID: 11890523 [PubMed - indexed for MEDLINE]
FULVIC/HUMIC References RELEVANT TO HUMANS/ANIMALS without on-line
abstracts:
1.
[Effectiveness of phenol body polymers against influenza virus A/Krasnodar/101/59/H2N2]
(German)
Mentel R, Helbig B, Klöcking R, Döhner L, Sprössig M.
Biomed Biochim Acta. 1983; 42(10):1353-6.
PMID: 6675676 [PubMed - indexed for MEDLINE]
2.
[Studies conducted at] Tongren Hospital, Beijing; 1988
Yuan, Shenyuan, et al
Application of Fulvic acid and its derivatives in the
fields of agriculture and medicine. Fulvic Acid, 4. June 1993; First Edition.
3.
The Use of a Processed Humic Acid Product as a Feed Supplement in
Dairy Production in the Netherlands.
B. P. H. Tomassen BPH, Faust RH.
IFOAM 2000: The World Grows Organic: Proceedings of the 13th International IFOAM
Conference. August, 2000; Basel, Switzerland.
4.
Anti-ulcerogenic activity of Fulvic Acids and
4-mehtoxy-6-carbomethoxybiphenyl isolated from Shilajit.
Shibnath Ghosal S, Jawahar Lal J, Sushil K. Singh SK, Kumar Y, Srivastava R.
Phytotherapy Research. 1988; Vol. 2, No. 4.
Help For Flu Vaccine Shortage
Natural humic acid coats viruses and makes it more difficult for them to attach to healthy cells
and multiply. It has shown to reduce viral counts in numerous patients with a variety of viral
inflictions including hepatitis and HIV.
(PRWEB) November 5, 2004 -- Viruses are extremely small organisms that can easily get inside
cells. They are parasitic in that they enter healthy cells where they reside and feed off these cells.
They raise their young within these cells to be spread to other cells inside and outside the body
(through sneezing, excretion of body fluids, sexual transmission, etc.)
Viruses contain a receptor-binding protein that keeps them attached to the healthy cell. This
protein encapsulates the virus and makes it resistant to attacks from the immune system. Humic
acid is a nutrient from the soil that dilates a healthy cell and causes permeability so it can enter.
When Fulvic Acid finds a virus it coats it with a substance that not only prevents the virus from
attaching to a healthy cell, but also sends a signal to the immune system alerting it of the invader.
This kicks the immune system into action against the virus that has been laid vulnerable by this
coating. As explained by Dr. Howard
Peiper in the book, "Live Disease Free" (to be released in December, 2004) special processing by
some supplement manufacturers creates a "viral infusion inhibitor" that prevents the virus from
reproducing. Therefore, viral counts are reduced and the immune system is more successful in
ridding the body of the virus before it can gain a foothold and create an illness.
Humic acid is selective and seems to know which cells are virus laden. It coats only those cells,
leaving the healthy cells alone so the immune sys-tem will attack only the virus. Studies have
shown no negative side effects when using humic acid.
The National Institute of Health in 2002 concluded that humic acids exhibit effects both as a
preventive and a curative from a broad range of viruses. They also indicated that if taken before
introduction of the virus, patients exhibited a strong prophylactic effect. As quoted from
Experientia, 1972 28(5) by Klocking and
Sprossig, "Medical studies show that difficult respiratory illnesses common in children are
readily resolved with humic acid dietary supplementation." With results like these humic acids
would be a worthy addition to a dietary regime during the flu season.
Radioactive Reactions with Fulvic and Humic Substances
According to Szaloy, radioactive elements react with humic substances and require only a brief time until
equilibrium is reached.
F.W. Pauli stated that the solubility, migration, and accumulation of uranium are influenced by humic
and fulvic acids. The fuel discharged from the light water reactors is contaminated with substantial
Szalay, A. (1958). The significance of humus in the geochemical enrichment of uranium. Preceedings
of the 2nd International conference on the Peaceful Uses of Atomic energy, 2, 182-186. (London:
Pergamon) amounts of plutonium and uranium. These ions react with humic compounds at a much
more rapid rate than do copper, nickel, lead, or cadmium ions.117 Pillai and Mathew agreed that it
would not be unrealistic to presume that the geochemical behavior of plutonium and uranium is
influenced by humic substances. They reported the presence of plutonium in purified organic
material extracted from coastal sediments and indicated the possibility of the accumulation of
plutonium on organic surfaces because the concentration of plutonium increased over time. As they
confirmed that the organic matter solubilized the plutonium, they discovered that the addition of
organic matter inhibited the hydrolysis and precipitation of the added plutonium. It was further
reported that this scenario duplicates the action with uranium and other radioactive elements.118
Rashid stated that nuclear reactor wastes contain unused uranium, the basic fuel, and long-lived
fission product nuclides and actinides, including plutonium, strontium-90, zirconium-95, iodine-129,
cesium-137 and cesium 135, all in abundance. Activated metals such as cobalt-60, iron-59, and
manganese-54 also are present in reactor waste. He states that the basic reactions of these materials
with humic substances are parallel to those of other transition and trace metals.119
“Radioactive elements have an affinity for humic and fulvic acids. They form organo-metal complexes
of different adsorptive stability and solubility. Uranium and plutonium are influenced by humic
substances as are other polluting metals, each being solubilized and absorbed, thereby annihilating
the specific radioactivity.”120
117 Pauli, F.W. (1975). Heavy metal humates and their behavior against hydrogen sulfide. Soil Science,
119, 98-105.
118 Pillai, K.C., & Mathew, E. (1976). Plutonium in the aquatic environment: Its behavior, distribution and
significance. In Transuranium nuclides in the environment (pp. 25-45). Proceeding of the Sumposium,
International Atomic Energy Agency, Vienna.
119 Rashid, M.A. (1985). Geochemistry of Marine Humic Substances. New York: Springer-Verlag.
120 W.R. Jackson PhD. (1993) Humic, Fulvic, and Microbal Balance: Organic Soil Conditioning (pp. 762-
763).