الي بدرسهم يدعيلنا
ما النا غير الله بهاد الفصل
1-certain changes happen in tumor cells to reduce recognition from Cytotoxic T-cells but it activates part of the innate system? Mutation in MHC proteins
2-Best finding that indicates malignancy ? invasion
3- Benign tumor ? Meningioma
5-a question talking about cells with hyperchromatic nuclei involving the whole thickness of the
membrane ? Carcinoma in situ
6- about melanoma ? more than one of the above ( tanning salon , mutation in CDKN2A )
10- patient with prostate cancer which of the following can be used to make sure that it's prostate cancer "(eshi zy heek ) ? Prostate specific antigen (PSA )
11-Women with ovarian carcinoma which has columnar cells , cartilage , bone , kol eshi what is it ?
Teratoma
14-so2al b7ki 3n Episten Barr virus o b7ki which is wrong ? patient with Burkitt lymphoma most
commonly have over-expression of LMP-1 (hyeh most commonly MYC overexpression )
15-eshi b7ki 3n el HPV o bs2l which is correct ? integration in the host genome cause over-expression of E6 E7 Protein
17-you are making salad and you were cut and the doctor was 7mar making the cut worse however the size of the wound has decreased because ? contraction of myofibroblast
18-you are making salad again and the doctor was not 7mar and the cut was healed after removal of stitches which is wrong ? injured tissue regain most of it's strength after removal of stitches
24-in tumor there was decreased expression of P16 and p14 but there was no detected mutation of these genes. How was it silenced ? methylation
25-a patient with abdominal pain then later biopsy revealed a mass of the pancreas with of the following
mutations are related to it ? mutation in TGF-B (SMAD )
27-a woman with a lump in her left breast and enlarged lymph nodes and nodes in the lungs the staging of the tumor is ? T4 N2 M1
29-anti inflammatory agent ? iL10
30- Product of lipoxygenase pathway ? leukotriene C4
31-Wrong about neutrophils ? they are never seen in chronic inflammation
----------------------------------------------------------------------------------------------------------------------------
1- ALL of the following has a minimal replicative activity in their normal state EXCEPT :
a- Hematopoietic cells
b- Smooth muscle cells
c- Hepatocytes
Answer: A
4- A man from JAPAN ............., the diagnosis shows that he has a cancer,
the most likely kind of cancer would he has is :
a- Colon Cancer
b- Prostatic Cancer
c- Stomach Cancer
C
5- Wound strength after sutures are removed at 1 week is :
a- 5% of the unwounded skin.
b-10% of the unwounded skin
c- 15% of the unwounded skin
d- 70% of the unwounded skin
e- 80% of the unwounded skin
B
6- A question about chronic myeloid leukemia ( CML ) : the answer : It shows an increased tyrosine kinase activity
7- Which of the following is true about Keloid :
Increased tissue granulation
9- hepatic cancer is more probably metastasized from :
a- brain
b- bladder
c- pancreas
d- Bone marrow
C
11- which statement is false ?
fibronectin is the most abundant glycoprotein in basement membrane ( must be laminin )
13- which of the following would not develop into cancer ?
leiomyoma of the uterus
15- which is involved in recruitment of smooth muscle cells in angiogenesis?
PDGF
18- which one of these is not an autosomal dominant disease
xeroderma pigmentosum
21- which of the following would lead to cell transformation ?
loss of the checkpoint between G1 and S
31- a CT scan showed a 4cm mass in the lung, tests revealed that it is bronchogenic carcinoma, patients also suffers from hypercalcemia and muscle weakness, the most likely cause of hypercalcemia is:
paraneoplastic syndromes
32- A patient with colocecum cancer what serum marker would be good to test in his/her case ?
Carcinoembryonic
33- Definitive test for cancer ?
excision biopsy
34- a disorder associated with mismatch repair :
hereditary non polyposis Coli
35- retinoblastoma develops when ?
there's a loss of heterogeneity
36- the wrong statement about a mutation of VHL gene:
Leads to a decrease in HIGF
37- a woman with a dysplastic tissue in the cervix that is occupying the full thickness of the epithelial
tissue , the best description is ?
Carcinoma in situ
38- HER2 is :
A growth factor receptor
39- about BRCA1 gene :
responsible for DNA repair
40- EBV virus in non-hodgkin lymphoma is associated with :
MYC t(14:18)
42- a question about the histological grading of prostate invasive cancer:
resemblance to the surrounding tissue
43- A 60 year old man ,working 30 years in a factory, bladder cancer, what is the agent?
aniline dye
44- Most frequent chemical agent to cause lung cancer:
a- benzopyrene alpha ( the most probable answer )
b- asbestos
-------------------------------------------------------------------------------------------------------------------------------
PATHOLOGY:
18- synthesis of MMPs inhibited by: TIMP
19- healing by first intention: minimal wound contraction
20- maximal improvement of the wound: 70% - 80% after 3 months
21- wrong statement: all cancers have a deadly course
22- most important feature related to malignancy: fixed to the skin
25- which of the following isn't sporadic cancer arise in the
childhood: skin cancer
26- wrong statement: Hamartoma is a congenital anomaly
27- wrong statement: the more anaplastic, the more likely to have
specialized function
29- anaplasia means: lack of differentiation
31- nucleotide excision repair defect: xeroderma pigmentosum
32- is not a precursor of cancer: hemangioma
33- wrong statement (tumor progression): don't involve developing
resistance for drugs
34- emerging hallmark: evasion of immune system
35- ERBB2 mutation: Amplification
37- 9:22 translocation: ABL
39- wrong statement (RB): E6 protein affects it
40- sense DNA damage and release TP53: ATM
41- inherited mutant in p53 gene cause: Li-Fraumeni
45- not an angiogenesis inhibitor: PDGF
48- wrong statement (metastasize): increase in regions rich in
blood vessels
49- HNCC .. correct: have microsatellite instability (MSI)
50- hypersensitivity to ionizing radiation: Ataxia telangiectasia
51- wrong about BRCA1: develop breast cancer in men
52- wrong combination: beta-naphthylamine-renal cell carcinoma
53- RNA virus induced cancer: T cell lymphoma/leukemia
54- wrong statement about Burkitt lymphoma in immunocompetent
patient:expr of LMP1
55- non-viral cancer: MALToma
56- cancer cachexia: result from the action of soluble factor
(cytokines)
57- hypercalcemia: PTHrP by squamous cell carcinoma
58- grade 1: well-differentiated
59- staging doesn't depend on: amount of necrosis