Lim CS, Kim HP, Yu NK, Kang SJ, Ko HG, Kim TH, Yang J, Ryu HH, Park T, Gim J, Nam HJ, Baek SH, Wegener S, Schmitz D, Boeckers TM, Lee MG, Kim E, Lee JH, Lee YS*, Kaang BK*. Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice. Neuropharmacology, 2017. 112(Pt A):104-112 [*Corresponding authors]

Zhou M, Greenhill S, Huang S, Silva TK, Sano Y, Wu S, Cai Y, Nagaoka Y, Sehgal M, Cai DJ, Lee YS, Fox K, Silva AJ. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. eLife, 2016. 5. pii: e20985.

Ryu HH, Lee YS. Cell type-specific roles of RAS-MAPK signaling in learning and memory: implications in neurodevelopmental disorders. Neurobiol Learn Mem. 2016. 135:13-21.

Sim SE, Lim CS, Kim JI, Seo D, Chun H, Yu NK, Lee J, Kang SJ, Ko HG, Choi JH, Kim TH, Jang EH, Han J, Park, JE, Jang DJ, Baek D, Lee YS*, Kaang BK*. The brain-enriched microRNA, miR-9-3p, regulates synaptic plasticity and memory. J Neurosci. 2016. 36(33):p.8641–52 [*Corresponding authors]

Rogerson T, Jayaprakash B, Cai DJ, Sano Y, Lee YS, Zhou Y, Bekal P, Deisseroth K, Silva AJ. Molecular and Cellular Mechanisms for Trapping and Activating Emotional Memories. Plos One. 2016. 11(8):e0161655.

Hwang S, Lee JH, Yang JE, Lim CS, Lee JA, Lee YS*, Lee K*. Kaang BK*. Everolimus improves neuropsychiatric symptoms in a patient with tuberous sclerosis carrying a novel TSC2 mutation. Mol Brain. 2016. 9(1):56. [*Corresponding authors]

Yu NK, Kim HF, Shim J, Kim S, Kim DW, Kwak C, Sim SE, Choi JH, Ahn S, Yoo J, Choi SL, Jang DJ, Lim CS, Lee YS, Kang C, Choi SY, Kaang BK. A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. Sci Rep. 2016. 6:22892

Kim S, Kim T, Lee HR, Jang EH, Ryu HH, Kang M, Rah SY, Yoo J, Lee B, Kim JI, Lim CS, Kim SJ, Kim UH, Lee YS*, Kaang BK*. Impaired learning and memory in CD38 null mutant mice. Mol Brain. 2016. 9(1):16 [Corresponding authors]

Lee. YS*, Lee JA., Kaang BK*. Regulation of mRNA stability by ARE-binding proteins in synaptic plasticity and memory. Neurobiol Learn Mem. 2015. 124: p.28-33 [*Corresponding authors]

Kang M.K., Ryu H.H., Lee Y.S., Comparisons of behavior and synaptic plasticity among three C57BL/6 substrains. Animal Cells Syst. 2015. 19(3): p. 181–187

Lee YS*, Ehninger D, Zhou M, Oh J-Y, Kang M, Kwak C, Ryu HH, Butz D, Araki T, Cai K, Balaji J, Sano Y, Nam CI, Kim HK, Kaang BK, Burger C, Neel BG, Silva AJ*. Mechanism and treatment for the learning and memory deficits associated with mouse models of Noonan syndrome. Nat Neurosci. 2014.17(12):p.1736-43 [*Corresponding authors]

Ryu HH, Jun MH, Min KJ, Jang DJ, Lee YS*, Kim HK*, Lee JA*. Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons. Neurobiol Aging. 2014. 35(12):p. 2822-31 [*Corresponding authors]

Choi JH, Park P, Baek GC, Sim SE, Kang S, Lee Y, Ahn SH, Lim CS, Lee YS, Collingridge GL, Kaang BK. Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning. Mol Brain. 2014.7(1):78

Kim KH, Jun YW, Park Y, Lee JA, Suh BC, Lim CS, Lee YS, Kaang BK, Jang DJ. Intracellular Membrane Association of the Aplysia cAMP Phosphodiesterase Long and Short Forms via Different Targeting Mechanisms. J Biol Chem. 2014. 289(37):p. 25797-811

Lee. Y.S. Genes and signaling pathways involved in memory enhancement in mutant mice, Mol Brain. 2014. 7(1): 43

Choi JH, Yu NK, Baek GC, Bakes J, Seo D, Nam HJ, Baek SH, Lim CS, Lee YS, Kaang BK. Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons. Mol Brain. 2014. 7:17

Lee Y.S., S.L. Choi, H. Jun, S.J. Yim, J. A. Lee, H. Kim, S.H. Lee, J. Shim, K. Lee, D. J. Jang, and B.K. Kaang, AU-rich element-binding protein negatively regulates CCAAT enhancer-binding protein mRNA stability during long-term synaptic plasticity in Aplysia, Proc Natl Acad Sci U S A, 2012. 109 (38):p. 15520-5

Acosta MT, Bearden CE, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee Y.S., Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, Silva AJ, The Learning Disabilities Network [LeaDNet]: Using Neurofibromatosis Type 1 as a Paradigm for Translational Research, Am J Med Genet A, 2012. 158A(9):p. 2225-32

Ehninger, D., Y. Sano, P.J. de Vries, K. Dies, D. Franz, D.H. Geschwind, M. Kaur, Y.S. Lee, W. Li, J.K. Lowe, J.A. Nakagawa, M. Sahin, K. Smith, V. Whittemore, and A.J. Silva, Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Mol Psychiatry, 2012. 17 (1): p. 62-70

Lee, Y.S. and A.J. Silva, Modeling hyperactivity: of mice and men. Nat Med, 2011. 17(5): p. 541-2.

Kye, M.J., P. Neveu, Y.S. Lee, M. Zhou, J.A. Steen, M. Sahin, K.S. Kosik, and A.J. Silva, NMDA Mediated Contextual Conditioning Changes miRNA Expression. PLoS One, 2011. 6(9): p. e24682.

Kim, J.I., H.R. Lee, S.E. Sim, J. Baek, N.K. Yu, J.H. Choi, H.G. Ko, Y.S. Lee, S.W. Park, C. Kwak, S.J. Ahn, S.Y. Choi, H. Kim, K.H. Kim, P.H. Backx, C.A. Bradley, E. Kim, D.J. Jang, K. Lee, S.J. Kim, M. Zhuo, G.L. Collingridge, and B.K. Kaang, PI3Kgamma is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat Neurosci, 2011. 14(11): p. 1447-54.

Shilyansky, C., Y.S. Lee, and A.J. Silva, Molecular and cellular mechanisms of learning disabilities: a focus on NF1. Annu Rev Neurosci, 2010. 33: p. 221-43.

Kaneko, M., C.E. Cheetham, Y.S. Lee, A.J. Silva, M.P. Stryker, and K. Fox, Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex. Proc Natl Acad Sci U S A, 2010. 107(44): p. 19026-31.

Choi, S.L., Y.S. Lee, Y.S. Rim, T.H. Kim, L.L. Moroz, E.R. Kandel, J. Bhak, and B.K. Kaang, Differential evolutionary rates of neuronal transcriptome in Aplysia kurodai and Aplysia californica as a tool for gene mining. J Neurogenet, 2010. 24(2): p. 75-82.

Buard, I., S.J. Coultrap, R.K. Freund, Y.S. Lee, M.L. Dell'Acqua, A.J. Silva, and K.U. Bayer, CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci, 2010. 30(24): p. 8214-20. (equal contribution)

Lee, Y.S. and A.J. Silva, The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci, 2009. 10(2): p. 126-40.

Lee, Y.S., T.H. Kim, S.L. Choi, S. Lee, J. Bhak, and B.K. Kaang, Transcriptome and protein domain analyses in Aplysia nervous system with evolutionary implications. Commun Integr Biol, 2009. 2(4): p. 321-3.

Lee, Y.S., S.L. Choi, S.H. Lee, H. Kim, H. Park, N. Lee, S.H. Lee, Y.S. Chae, D.J. Jang, E.R. Kandel, and B.K. Kaang, Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia. Proc Natl Acad Sci U S A, 2009. 106(34): p. 14634-9. (recognized by Faculty of 1000 Biology)

Wayman, G.A., Y.S. Lee, H. Tokumitsu, A.J. Silva, and T.R. Soderling, Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron, 2008. 59(6): p. 914-31.

Lee, Y.S., S.L. Choi, T.H. Kim, J.A. Lee, H.K. Kim, H. Kim, D.J. Jang, J.J. Lee, S. Lee, G.S. Sin, C.B. Kim, Y. Suzuki, S. Sugano, T. Kubo, L.L. Moroz, E.R. Kandel, J. Bhak, and B.K. Kaang, Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai. Proc Natl Acad Sci U S A, 2008. 105(47): p. 18602-7.

Lee, Y.S., C.H. Bailey, E.R. Kandel, and B.K. Kaang, Transcriptional regulation of long-term memory in the marine snail Aplysia. Mol Brain, 2008. 1: p. 3.

Isiegas, C., C. McDonough, T. Huang, R. Havekes, S. Fabian, L.J. Wu, H. Xu, M.G. Zhao, J.I. Kim, Y.S. Lee, H.R. Lee, H.G. Ko, N. Lee, S.L. Choi, J.S. Lee, H. Son, M. Zhuo, B.K. Kaang, and T. Abel, A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci, 2008. 28(24): p. 6220-30.

Shum, F.W., L.J. Wu, M.G. Zhao, H. Toyoda, H. Xu, M. Ren, R. Pinaud, S.W. Ko, Y.S. Lee, B.K. Kaang, and M. Zhuo, Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn Mem, 2007. 14(4): p. 304-12.

Lee, S.H., C.S. Lim, H. Park, J.A. Lee, J.H. Han, H. Kim, Y.H. Cheang, S.H. Lee, Y.S. Lee, H.G. Ko, D.H. Jang, H. Kim, M.C. Miniaci, D. Bartsch, E. Kim, C.H. Bailey, E.R. Kandel, and B.K. Kaang, Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia. Cell, 2007. 129(4): p. 801-12.

Yim, S.J., Y.S. Lee, J.A. Lee, D.J. Chang, J.H. Han, H. Kim, H. Park, H. Jun, V.N. Kim, and B.K. Kaang, Regulation of ApC/EBP mRNA by the Aplysia AU-rich element-binding protein, ApELAV, and its effects on 5-hydroxytryptamine-induced long-term facilitation. J Neurochem, 2006. 98(2): p. 420-9. (equal contribution)

Lee, J.A., S.H. Lee, C. Lee, D.J. Chang, Y. Lee, H. Kim, Y.H. Cheang, H.G. Ko, Y.S. Lee, H. Jun, D. Bartsch, E.R. Kandel, and B.K. Kaang, PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation. J Cell Biol, 2006. 174(6): p. 827-38.

Ko, S.W., Y. Jia, H. Xu, S.J. Yim, D.H. Jang, Y.S. Lee, M.G. Zhao, H. Toyoda, L.J. Wu, T. Chatila, B.K. Kaang, and M. Zhuo, Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci, 2006. 23(8): p. 2158-68.

Kim, H., S.H. Lee, J.H. Han, J.A. Lee, Y.H. Cheang, D.J. Chang, Y.S. Lee, and B.K. Kaang, A nucleolar protein ApLLP induces ApC/EBP expression required for long-term synaptic facilitation in aplysia neurons. Neuron, 2006. 49(5): p. 707-18.

Zhao, M.G., H. Toyoda, Y.S. Lee, L.J. Wu, S.W. Ko, X.H. Zhang, Y. Jia, F. Shum, H. Xu, B.M. Li, B.K. Kaang, and M. Zhuo, Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 2005. 47(6): p. 859-72. (equal contribution)

Wu, L.J., H. Toyoda, M.G. Zhao, Y.S. Lee, J. Tang, S.W. Ko, Y.H. Jia, F.W. Shum, C.V. Zerbinatti, G. Bu, F. Wei, T.L. Xu, L.J. Muglia, Z.F. Chen, Y.P. Auberson, B.K. Kaang, and M. Zhuo, Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci, 2005. 25(48): p. 11107-16.

Shum, F.W., S.W. Ko, Y.S. Lee, B.K. Kaang, and M. Zhuo, Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV. Mol Pain, 2005. 1: p. 22.

Park, H., J.A. Lee, C. Lee, M.J. Kim, D.J. Chang, H. Kim, S.H. Lee, Y.S. Lee, and B.K. Kaang, An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation. J Neurosci, 2005. 25(39): p. 9037-45.

Jang, D.H., J.H. Han, S.H. Lee, Y.S. Lee, H. Park, S.H. Lee, H. Kim, and B.K. Kaang, Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses. Proc Natl Acad Sci U S A, 2005. 102(44): p. 16072-7.

Han, J.H., C.S. Lim, Y.S. Lee, E.R. Kandel, and B.K. Kaang, Role of Aplysia cell adhesion molecules during 5-HT-induced long-term functional and structural changes. Learn Mem, 2004. 11(4): p. 421-35.

Lee, Y., J.H. Han, C.S. Lim, D.J. Chang, Y.S. Lee, H. Soh, C.S. Park, and B.K. Kaang, Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance Ca2+-activated K+ channel in Aplysia neuron R15. Neurosci Lett, 2003. 349(1): p. 53-7.

Lee, Y., D.J. Chang, Y.S. Lee, K.A. Chang, H. Kim, J.S. Yoon, S. Lee, Y.H. Suh, and B.K. Kaang, Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. J Neurosci Res, 2003. 73(2): p. 255-9.

Lee, J.A., H. Kim, Y.S. Lee, and B.K. Kaang, Overexpression and RNA interference of Ap-cyclic AMP-response element binding protein-2, a repressor of long-term facilitation, in Aplysia kurodai sensory-to-motor synapses. Neurosci Lett, 2003. 337(1): p. 9-12.

Kim, H., D.J. Chang, J.A. Lee, Y.S. Lee, and B.K. Kaang, Identification of nuclear/nucleolar localization signal in Aplysia learning associated protein of slug with a molecular mass of 18 kDa homologous protein. Neurosci Lett, 2003. 343(2): p. 134-8.

Suh, S.J., Y.S. Park, Y.S. Lee, T.J. Cho, B.K. Kaang, and N.J. Cho, Three functional isoforms of GAR-2, a Caenorhabditis elegans G-protein-linked acetylcholine receptor, are produced by alternative splicing. Biochem Biophys Res Commun, 2001. 288(5): p. 1238-43.

Lee, J.A., H.K. Kim, K.H. Kim, J.H. Han, Y.S. Lee, C.S. Lim, D.J. Chang, T. Kubo, and B.K. Kaang, Overexpression of and RNA interference with the CCAAT enhancer-binding protein on long-term facilitation of Aplysia sensory to motor synapses. Learn Mem, 2001. 8(4): p. 220-6.

Park, Y.S., Y.S. Lee, N.J. Cho, and B.K. Kaang, Alternative splicing of gar-1, a Caenorhabditis elegans G-protein-linked acetylcholine receptor gene. Biochem Biophys Res Commun, 2000. 268(2): p. 354-8. (equal contribution)

Myeong, H., D. Jeoung, H. Kim, J.H. Ha, Y. Lee, K.H. Kim, C. Park, and B.K. Kaang, Genomic analysis and functional expression of canine dopamine D2 receptor. Gene, 2000. 257(1): p. 99-107.

Lee, Y.S., Y.S. Park, S. Nam, S.J. Suh, J. Lee, B.K. Kaang, and N.J. Cho, Characterization of GAR-2, a novel G protein-linked acetylcholine receptor from Caenorhabditis elegans. J Neurochem, 2000. 75(5): p. 1800-9.

Lee, Y.S., J.A. Lee, J. Jung, U. Oh, and B.K. Kaang, The cAMP-dependent kinase pathway does not sensitize the cloned vanilloid receptor type 1 expressed in xenopus oocytes or Aplysia neurons. Neurosci Lett, 2000. 288(1): p. 57-60.

Chang, D.J., X.C. Li, Y.S. Lee, H.K. Kim, U.S. Kim, N.J. Cho, X. Lo, K.R. Weiss, E.R. Kandel, and B.K. Kaang, Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation in aplysia sensory neurons. Proc Natl Acad Sci U S A, 2000. 97(4): p. 1829-34.

Lee, Y.S., Y.S. Park, D.J. Chang, J.M. Hwang, C.K. Min, B.K. Kaang, and N.J. Cho, Cloning and expression of a G protein-linked acetylcholine receptor from Caenorhabditis elegans. J Neurochem, 1999. 72(1): p. 58-65.

Hwang, J.M., D.J. Chang, U.S. Kim, Y.S. Lee, Y.S. Park, B.K. Kaang, and N.J. Cho, Cloning and functional characterization of a Caenorhabditis elegans muscarinic acetylcholine receptor. Receptors Channels, 1999. 6(6): p. 415-24.

BOOK CHAPTERS [International]

Lee, Y.S., Transgenic mice with enhanced cognition, in Cognitive enhancement, Pharmacologic, environmental and genetic factors, S. Knafo and C. Venero, Editor. 2015, Academic Press. p. 87­–110. ISBN 9780124170421

Lee, Y.S. and A.J. Silva, Molecular and cellular approaches to cognitive impairments associated with NF1 and other Rasopathies, in Neurofibromatosis Type 1: Molecular and Cellular Biology, M. Upadhyaya and D. Cooper, Editor. 2012, Springer-Verlag. p. 569 - 588.  ISBN 978-642-32863-3

Lee, Y.S. and A.J. Silva, Knock-Outs: Learning and Memory, in Encyclopedia of Behavioral Neuroscience, L.M.M.a.T.R.F. Koob G.F., Editor. 2010, Academic Press: Oxford. p. 123–130. ISBN 9780080447322